Longitudinal Changes in Ki-67 Indices in Small-Intestinal Neuroendocrine Tumours and Their Impact on Survival.

Introduction: The purpose of this study was to evaluate longitudinal changes in Ki-67 indices of SI-NETs and assess the impact of these in overall survival (OS).

Methods: We screened 551 patients with SI-NETs diagnosed from 1993, through 2021, identified using the SI-NET databases from five European referral centres. Only patients with well-differentiated tumours and available baseline tumour samples and follow-up re-biopsies were included.

Modified Histopathological Grading Optimizes Prediction of Survival Outcomes in Small Intestinal Neuroendocrine Tumors.

Context: One of the major prognostic indices in neuroendocrine tumors (NETs) is Ki67 proliferation index.

Objective: To identify optimal grading Ki67 cutoffs to delineate differences in prognosis of patients with small intestinal NETs (SI-NETs).

Methods: Multicenter retrospective cohort analysis of 551 SI-NET patients diagnosed from 1993 through 2021 at 5 European referral centers with a mean (±SD) follow-up time of 51.

A scoping review on technology applications in agricultural extension.

Agricultural extension plays a crucial role in disseminating knowledge, empowering farmers, and advancing agricultural development. The effectiveness of these roles can be greatly improved by integrating technology. These technologies, often grouped into two categories-agricultural technology and educational technology-work together to yield the best outcomes.

Pro-Gastrin-Releasing Peptide as a Biomarker in Lung Neuroendocrine Neoplasm.

There is a lack of effective biomarkers for diagnosing lung neuroendocrine neoplasms (LNENs). A known small cell lung cancer (SCLC) biomarker is a pro-gastrin-releasing peptide (ProGRP), but not for all LNENs, especially for bronchopulmonary carcinoids. This study aimed to evaluate the diagnostic value of ProGRP and chromogranin A (CgA) in diagnosing LNENs.

Pancreatic metastases in patients with neuroendocrine neoplasms: A multi-centre cohort study.

Pancreatic metastases (PMs) from neuroendocrine neoplasms (NENs) are rare but the increased sensitivity of new diagnostic tools such as Ga-DOTATATE PET/CT has resulted in their increased recognition at initial diagnosis or follow-up. A retrospective analysis of the data of patients from six tertiary referral centres was performed in order to identify the characteristics and the prognostic significance of PMs in patients with NENs. We used a control group of 69 age-, sex- and primary tumour - matched NEN patients from the same cohort with stage IV disease but no PMs.

Research data management needs assessment for social sciences graduate students: A mixed methods study.

The complexity and privacy issues inherent in social science research data makes research data management (RDM) an essential skill for future researchers. Data management training has not fully addressed the needs of graduate students in the social sciences. To address this gap, this study used a mixed methods design to investigate the RDM awareness, preparation, confidence, and challenges of social science graduate students.

The effect of student engagement strategies in online instruction for data management skills.

Evaluating the effectiveness of teaching methods for synchronous online instruction is integral to fostering student engagement and maximizing student learning, particularly in one-time workshops or seminars. Using the lens of social constructivism theory, this study investigated the effect of different approaches of synchronous online instruction on the development of graduate students' research data management (RDM) skills during the post-pandemic era. One experimental group received teacher-centered instruction primarily via lecture and the second experimental group received student-centered instruction with active learning activities.

Association of lymph node metastases, grade and extent of mesenteric lymph node dissection in locoregional small intestinal neuroendocrine tumors with recurrence-free survival.

We aimed to assess the prognostic impact of tumor- and patient-related parameters in patients with stage I-III small intestinal neuroendocrine tumors (SI-NETs), who underwent locoregional resective surgery (LRS) with curative intent. We included 229 patients with stage I-III SI-NETs diagnosed from June 15, 1993, through March 8, 2021, identified using the SI-NET databases from five European referral centers. Mean ± SD age at baseline was 62.

Superfluid liquid helium control for the primordial inflation polarization explorer balloon payload.

The Primordial Inflation Polarization Explorer (PIPER) is a stratospheric balloon payload to measure the polarization of the cosmic microwave background. Twin telescopes mounted within an open-aperture bucket dewar couple the sky to bolometric detector arrays. We reduce detector loading and photon noise by cooling the entire optical chain to 1.

Anti-reflection coated vacuum window for the Primordial Inflation Polarization ExploreR (PIPER) balloon-borne instrument.

Measuring the faint polarization signal of the cosmic microwave background (CMB) not only requires high optical throughput and instrument sensitivity but also control over systematic effects. Polarimetric cameras or receivers used in this setting often employ dielectric vacuum windows, filters, or lenses to appropriately prepare light for detection by cooled sensor arrays. These elements in the optical chain are typically designed to minimize reflective losses and hence improve sensitivity while minimizing potential imaging artifacts such as glint and ghosting.

The balloon-borne cryogenic telescope testbed mission: Bulk cryogen transfer at 40 km altitude.

The balloon-borne cryogenic telescope testbed is a stratospheric balloon payload intended to develop technology for a future cryogenic suborbital observatory. A series of flights are intended to establish ultra-light dewar performance and open-aperture observing techniques for large (3 m-5 m diameter) cryogenic telescopes at infrared wavelengths. An initial flight in 2019 demonstrated bulk transfer of liquid nitrogen and liquid helium at stratospheric altitudes.

The effect of prophylactic surgery in survival and HRQoL in appendiceal NEN.

Background/aims: Long-term outcomes are understudied in patients with well-differentiated appendiceal neuroendocrine neoplasms (WD-ANENs). We aimed to evaluate the validity of currently applied criteria for completion prophylactic right hemicolectomy (pRHC) and determine its association with patient outcomes, including health-related quality of life (HRQoL).

Methods: Eligible patients from five European referral centers were divided between those who underwent appendectomy alone and those who underwent completion pRHC.

In-Vivo and Ex-Vivo Measurements of Blood Glucose Using Whispering Gallery Modes.

Unlabelled: The permittivity of blood glucose is not a strong function of its concentration in microwave or millimeter-wave frequencies. Measuring glucose concentrations remains a challenge, particularly in the presence of interference caused by the ambient leaky waves. In this paper, however, we demonstrate that a near-linear correlation between the glucose concentration and the blood permittivity was noticeably observed at a whispering gallery mode resonance.

Research platform for medical device development to simplify translation to the market.

New regulations for medical products complicate research projects for new application fields and translation of innovative product ideas to refundable medical products becomes a high economic risk. All this demands for a CE-marked platform, which offers the possibility to access the recorded data online or even directly the hardware during research applications, to bridge the gap. This paper describes how a CE-marked medical product can be extended by different interfaces to enable basic research or simplify first proof-of-concept studies thus optimizing prototype development in research projects, simplifying the documentation process and reducing the risk for market access.

Sub-Kelvin cooling for two kilopixel bolometer arrays in the PIPER receiver.

The Primordial Inflation Polarization Explorer (PIPER) is a balloon-borne telescope mission to search for inflationary gravitational waves from the early universe. PIPER employs two 32 × 40 arrays of superconducting transition-edge sensors, which operate at 100 mK. An open bucket Dewar of liquid helium maintains the receiver and telescope optics at 1.

A hybrid auricular control system: direct, simultaneous, and proportional myoelectric control of two degrees of freedom in prosthetic hands.

Objective: The conventional myoelectric control scheme of hand prostheses provides a high level of robustness during continuous use. Typically, the electrical activity of an agonist/antagonist muscle pair in the forearm is detected and used to control either opening/closing or rotation of the prosthetic hand. The translation of more sophisticated control approaches (e.

Steer by ear: Myoelectric auricular control of powered wheelchairs for individuals with spinal cord injury.

Purpose: Providing mobility solutions for individuals with tetraplegia remains challenging. Existing control devices have shortcomings such as varying or poor signal quality or interference with communication. To overcome these limitations, we present a novel myoelectric auricular control system (ACS) based on bilateral activation of the posterior auricular muscles (PAMs).

Polarization properties of a broadband multi-moded concentrator.

We present the design and performance of a non-imaging concentrator for use in broadband polarimetry at millimeter through submillimeter wavelengths. A rectangular geometry preserves the input polarization state as the concentrator couples f/2 incident optics to a 2π sr detector. Measurements of the co-polar and cross-polar beams in both the few-mode and highly over-moded limits agree with a simple model based on mode truncation.

Variable-delay polarization modulators for cryogenic millimeter-wave applications.

We describe the design, construction, and initial validation of the variable-delay polarization modulator (VPM) designed for the PIPER cosmic microwave background polarimeter. The VPM modulates between linear and circular polarization by introducing a variable phase delay between orthogonal linear polarizations. Each VPM has a diameter of 39 cm and is engineered to operate in a cryogenic environment (1.