Early Molecular Response to Imatinib First-Line Therapy and Predictive Factors of Poor Outcomes for Chronic Myeloid Leukemia Patients in Côte d'Ivoire.

The present study aimed to evaluate for the first time, the early molecular response (EMR) to imatinib at 3 months for patients with chronic myeloid leukemia and to determine the predictive factors that influence poor outcome and response. 60 newly diagnosed CML patients were enrolled from May 2018 to June 2023. They received imatinib and prospectively underwent a molecular evaluation.

[Prehypertension and hypertension : Analysis of sociodemographic and behavioral factors in an Ivorian population].

Introduction: Hypertension is one of the preventable causes of premature morbidity and mortality worldwide. The term "prehypertension", defined as systolic blood pressure (BP) between 120 and 139 mmHg and/or diastolic BP between 80 and 89 mmHg, was introduced in 2003 and concerns around 25% to 50% of adults worldwide. The objective of this work was to describe some sociodemographic and behavioral factors associated with prehypertension compared to hypertension in a black population.

Combining ability analysis of Cucurbita moschata D. in Côte d'Ivoire and classification of promising lines based on their gca effects.

Cucurbita moschata varieties grown in Africa have very low yield. They have been neglected, and totally ignored in agricultural research programs. However, interest in their fruits, seeds, flowers and leaves is growing nowadays due to their nutritional and medicinal potentials.

Annual and geographical variations in the specific composition of jassids and their damage on cotton in Ivory Coast.

In recent years, jassids have become a real problem for cotton growing in Ivory Coast. It is important to investigate the causes of this problem. The aim of this study was to highlight the diversity of jassid species and their impact on cotton growing in Ivory Coast.

Pediatric maxillofacial and oral traumatological emergencies in the department of stomatology, maxillofacial and plastic surgery of the university hospital of cocody (republic of IVORY COAST).

Introduction: Maxillofacial and oral trauma in children are a frequent reason for consultation in stomatology and maxillofacial surgery.

Patients And Methods: Retrospective study with a descriptive aim, carried out on the basis of an analysis of the physical medical files of cases of maxillofacial and oral trauma admitted to the stomatological emergencies of the university hospital center of cocody over a period of 04 years (January 2016 to December 2019).

Results: The average age of the patients was 7.

Seroprevalence of porcine cysticercosis in traditional farms in South-Eastern Côte d'Ivoire.

Background: Porcine cysticercosis is an endemic parasitic zoonosis in many developing countries. The objective of this study was to estimate the seroprevalence of porcine cysticercosis in traditional pig farms in the departments of Dabou, Aboisso and Agboville.

Methods: Blood samples were taken from pigs and analyzed by ELISA (IgG) and western blot.

[Not Available].

Introduction: The detection of hypertension in African countries ranges from 15 to 40%, so more than half of hypertensive people are unaware of their condition. In Côte d’Ivoire, very little work on the detection of hypertension exists.

Purpose Of Research: The objective was to analyze the detection and control of hypertension in the Ivorian peri-urban environment.

Validation of the Canadian French version of the fear of COVID-19 scale in the general population of Quebec.

Background: The purpose of this study was to develop a Canadian French translation of the fear of COVID-19 scale (FCV-19S) and assess its psychometric characteristics.

Methods: A forward and backtranslation process was conducted for the Canadian French version of the FCV-19S. The guidance of the ISPOR task force for translation and cultural adaptation was followed and cognitive debriefing interviews were conducted with six citizens.

The Role of GH/IGF Axis in Dento-Alveolar Complex from Development to Aging and Therapeutics: A Narrative Review.

The GH/IGF axis is a major regulator of bone formation and resorption and is essential to the achievement of normal skeleton growth and homeostasis. Beyond its key role in bone physiology, the GH/IGF axis has also major pleiotropic endocrine and autocrine/paracrine effects on mineralized tissues throughout life. This article aims to review the literature on GH, IGFs, IGF binding proteins, and their respective receptors in dental tissues, both epithelium (enamel) and mesenchyme (dentin, pulp, and tooth-supporting periodontium).

Efficacy and Tolerance of Vascular Electrical Stimulation Therapy in the Management of Vaso-Occlusive Crises in Patients with Sickle Cell Disease: A Phase II Single-Centre Randomized Study in Ivory Coast.

Background: Vaso-occlusive crisis (VOC) is the primary cause of hospitalization in patients with sickle cell disease. Treatment mainly consists of intravenous morphine or nonsteroidal anti-inflammatory drugs (NSAIDs), which have many dose-related side effects. The question arises as to whether vascular electrical stimulation therapy (VEST) could be effective or not on VOCs.

New Putative Antimicrobial Candidates: Design of Fish-Derived Antibacterial Peptide-Motifs.

Antimicrobial resistance remains a great threat to global health. In response to the World Health Organizations' global call for action, nature has been explored for novel and safe antimicrobial candidates. To date, fish have gained recognition as potential source of safe, broad spectrum and effective antimicrobial therapeutics.

Assessment of hybrid vigour, dominance effect and hybrids regeneration potential in the genus .

hybrid vigour for hybrids resulting from crosses among six genotypes of the genus , including . . For such purpose, the mid parent heterosis and the best parent heterosis were assessed.

Molecular confirmation of varietal status in bottle gourd () using genotyping-by-sequencing.

Bottle gourd () is an important food, medicinal, and utilitarian crop with a large pan-tropical distribution. Two morphologically different types in the subspecies are sufficiently different to be considered as varieties, but they are assigned into different taxonomic ranks. Genotyping-by-sequencing (GBS) of 95 different accessions from the Nangui Abrogoua University collection was used to confirm the varietal status in bottle gourd.

AMAFRICA, a patient-navigator program for accompanying lymphoma patients during chemotherapy in Ivory Coast: a prospective randomized study.

Background: Previous studies have indicated that accompanying socially underserved cancer patients through Patient Navigator (PN) or PN-derived procedures improves therapy management and reassurance. At the Cancer Institute of Toulouse-Oncopole (France), we have implemented AMA (Ambulatory Medical Assistance), a PN-based procedure adapted for malignant lymphoma (ML) patients under therapy. We found that AMA improves adherence to chemotherapy and safety.

Prevalence and variation of viviparous germination with respect to fruit maturation in the bottle gourd (Molina) Standley (Cucurbitaceae).

Researches documenting comprehensively the prevalence of seed vivipary in relation to phenology, as well as its impact on production are scant. This article reports the results of investigations carried out during four cropping seasons to quantitatively document seed vivipary in the oleaginous bottle gourd (). Field experiments were conducted during the first and second cropping season of 2014 and 2015 at the experimental station of Nangui Abrogoua University (Abidjan, Côte d'Ivoire).

Diabetic and cardiovascular patients' willingness to pay for upcoming national health insurance scheme in Côte d'Ivoire.

Background: Côte d'Ivoire's current health care financing system results from successive reforms undertaken with government funding and international support. The country is moving towards a national compulsory health insurance scheme. This context offered an opportunity to study additional features of health insurance's potential market in Sub-Sahara Africa developing economy.

Immunohistochemical Evaluation of Ki-67 and Comparison with Clinicopathologic Factors in Breast Carcinomas.

Background: Patients primarily received tamoxifen based on their menopausal status due to the lack of immunohistochemistry. A recent study has shown that hormonal receptors were not correlated with menopausal status, and thus, indicating that they present limited therapeutic and prognostic significance in breast cancer management. This study aimed to evaluate Ki-67 value and analyze its association with clinicopathologic parameters in breast cancer patients.

HER2 overexpression and correlation with other significant clinicopathologic parameters in Ivorian breast cancer women.

Background: The overexpression of HER2 is associated with worse prognosis of breast cancer which responds favourably to anti-HER2 therapy. The objective of this study was to determine the frequency of HER2 and its association with clinicopathologic factors in breast cancer in Ivory Coast.

Methods: The study included 608 patients who were histologically diagnosed with invasive primary breast carcinoma.

Efficacy of Interceptor G2, a new long-lasting insecticidal net against wild pyrethroid-resistant Anopheles gambiae s.s. from Côte d'Ivoire: a semi-field trial.

Background: The widespread insecticide resistance in malaria vector populations is a serious threat to the efficacy of vector control tools. As a result, the World Health Organization (WHO) supports the development of alternative tools that combine several insecticides with the aim of improving vector control and the management of insecticide resistance. In the present study, a long-lasting insecticidal net treated with a mixture of chlorfenapyr and alphacypermethrin was evaluated against wild pyrethroid-resistant Anopheles gambiae s.

Mapping insecticide resistance in Anopheles gambiae (s.l.) from Côte d'Ivoire.

Background: Insecticide resistance in malaria vectors is an increasing threat to vector control tools currently deployed in endemic countries. Resistance management must be an integral part of National Malaria Control Programmes' (NMCPs) next strategic plans to alleviate the risk of control failure. This obviously will require a clear database on insecticide resistance to support the development of such a plan.

Percutaneous coronary intervention with second-generation drug-eluting stent versus bare-metal stent: Systematic review and cost-benefit analysis.

Background: Drug-eluting stents (DESs) were considered as ground-breaking technology promising to eradicate restenosis and the necessity to perform multiple revascularization procedures subsequent to percutaneous coronary intervention. Soon after DESs were released on the market, however, there were reports of a potential increase in mortality and of early or late thrombosis. In addition, DESs are far more expensive than bare-metal stents (BMSs), which has led to their limited use in many countries.

Aseptic artificial fermentation of cocoa beans can be fashioned to replicate the peptide profile of commercial cocoa bean fermentations.

The fermentation of cocoa beans is essential for the generation of flavour precursors that are required later on to form the flavour components of chocolate. From the many different precursors that are generated, oligopeptides and free amino acids comprise a significant proportion as some of them form Maillard reaction products during the roasting process. Therefore, the diversity of peptides is an important contributing factor to the quality of a fermentation which is in turn controlled by proteolytic activity within the cocoa bean, and is driven by changes in the presence of fermentation by-products as a result of microbial activity outside the bean.

Immunohistochemical determination of estrogen and progesterone receptors in breast cancer: relationship with clinicopathologic factors in 302 patients in Ivory Coast.

Background: Breast cancer is a heterogeneous and a hormone-dependent disease. The detection of the estrogen receptor (ER) and progesterone receptor (PgR) is crucial for prognostic evaluation and treatment choice of breast cancer for clinical practice. The purpose of this study was to evaluate the expression of the hormonal receptors, their distribution, and their correlation with clinicopathologic prognostic parameters for the improvement of the patients' treatment in Ivory Coast.

[Why and how to perform an ultrasound-guided transversus abdominis plane block: A step-by-step approach].

Used in clinical practice as part of a multimodal analgesic regimen, the transversus abdominis plane block (TAP block) is a relative novel procedure in which local anaesthetic agents are injected into the anatomic neurofascial space between the internal oblique and the transversus abdominis muscle. It allows a significantly prolonged duration of analgesia during the early postoperative stage in abdominal surgery. This regional anesthesia technique provides analgesia to the skin, muscles of the anterior abdominal wall and parietal peritoneum in order to decrease the incision-related pain.