Psychosocial work stress and parent-child bonding during the COVID-19 pandemic: clarifying the role of parental symptoms of depression and aggressiveness.

Background: Parental work stress and impaired mental health seem to have intensified during the current COVID-19 pandemic. Both can have a negative impact on parent-child bonding: psychosocial work stress in the course of a spillover effect from work to family and symptoms of impaired mental health as part of a crossover effect from parent to child. This potentially affects the child's development in the long term.

Female Patients with Pneumonia on Intensive Care Unit Are under Risk of Fatal Outcome.

The impact of sex on mortality in patients with pneumonia requiring intensive care unit (ICU) treatment is still a controversial discussion, with studies providing heterogeneous results. The reasons for sex differences are widespread, including hormonal, immunologic and therapeutic approaches. This study's aim was to evaluate sex-related differences in the mortality of ICU patients with pneumonia.

The effect of polymer properties on direct compression and drug release from water-insoluble controlled release matrix tablets.

The objective of this study was to identify and evaluate key polymer properties affecting direct compression and drug release from water-insoluble matrices. Commonly used polymers, such as Kollidon(®) SR, Eudragit(®) RS and ethyl cellulose, were characterized, formulated into tablets and compared with regard to their properties in dry and wet state. A similar site percolation threshold of 65% v/v was found for all polymers in dry state.

In situ forming implants for the delivery of metronidazole to periodontal pockets: formulation and drug release studies.

This study was performed to obtain prolonged drug release with biodegradable in situ forming implants for the local delivery of metronidazole to periodontal pockets. The effect of polymer type (capped and uncapped PLGA), solvent type (water-miscible and water-immiscible) and the polymer/drug ratio on in vitro drug release studies were investigated. In situ implants with sustained metronidazole release and low initial burst consisted of capped PLGA and N-methyl-2-pyrolidone as solvent.

PLGA in situ implants formed by phase inversion: critical physicochemical parameters to modulate drug release.

In situ forming implants (ISI) based on phase separation by solvent exchange represent an attractive alternative to conventional preformed implants and microparticles for parenteral applications. They are indeed easier to manufacture and their administration does not require surgery, therefore improving patient compliance. They consist of polymeric solutions precipitating at the site of injection and thus forming a drug eluting depot.

Improved physical stability and injectability of non-aqueous in situ PLGA microparticle forming emulsions.

The goal of this study was to obtain physically stable non-aqueous in situ forming microparticle (ISM) emulsions capable of forming biodegradable microparticles upon injection. ISM emulsions consist of a biocompatible organic PLGA solution dispersed in a continuous oil phase prepared in a two-syringe/connector system prior to administration. A variety of parenteral approved excipients were tested for a stability-enhancing effect and possible stabilization mechanisms evaluated.

The national ambient air monitoring strategy: rethinking the role of national networks.

A current re-engineering of the United States routine ambient monitoring networks intended to improve the balance in addressing both regulatory and scientific objectives is addressed in this paper. Key attributes of these network modifications include the addition of collocated instruments to produce multiple pollutant characterizations across a range of representative urban and rural locations in a new network referred to as the National Core Monitoring Network (NCore). The NCore parameters include carbon monoxide (CO), sulfur dioxide (SO2), reactive nitrogen (NOy), ozone (O3), and ammonia (NH3) gases and the major fine particulate matter (PM2.

Characterization of cis- and trans-HSSOH via rotational spectroscopy and quantum-chemical calculations.

Assisted by high-level quantum-chemical calculations, the cis and trans conformers of HSSOH have been unambiguously identified among the products of the flash-vacuum pyrolysis of tert-butylthiosulfinic acid S-tert-butylester by using rotational spectroscopy.

The rotational spectrum of H(32)SOH and H(34)SOH above 1 THz.

Accurate spectral data of H(32)SOH and H(34)SOH at 1.3 THz were recorded using a synthesizer based multiplier spectrometer. The spectra were analyzed together with data from an earlier study which contain measurements at 1.

Sources of fine particles in a rural midwestern U.S. area.

Ambient PM2.5 (particulate matter < or = 2.5 microm in aerodynamic diameter) samples collected at a rural monitoring site in Bondville, IL on every third day using Interagency Monitoring of Protected Visual Environments (IMPROVE) sampler were analyzed through the application of the positive matrix factorization (PMF).

An outreach intervention for older rural African Americans.

This article describes the process, approaches, and selected outcomes of a rural care management outreach intervention for older African Americans in South Carolina. The model is a community-academic partnership between a federally qualified community health center, a rural health clinic, and the Medical University of South Carolina. Its aim is to improve access to and utilization of health care and social services to enhance the quality of life of older African Americans.