Biobanking in everyday clinical practice in psychiatry-The Munich Mental Health Biobank.

Translational research on complex, multifactorial mental health disorders, such as bipolar disorder, major depressive disorder, schizophrenia, and substance use disorders requires databases with large-scale, harmonized, and integrated real-world and research data. The Munich Mental Health Biobank (MMHB) is a mental health-specific biobank that was established in 2019 to collect, store, connect, and supply such high-quality phenotypic data and biosamples from patients and study participants, including healthy controls, recruited at the Department of Psychiatry and Psychotherapy (DPP) and the Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital of the Ludwig-Maximilians-University (LMU), Munich, Germany. Participants are asked to complete a questionnaire that assesses sociodemographic and cross-diagnostic clinical information, provide blood samples, and grant access to their existing medical records.

Evaluation of the automated cartridge-based ARIES SARS-CoV-2 Assay (RUO) against automated Cepheid Xpert Xpress SARS-CoV-2 PCR as gold standard.

Introduction: To evaluate the automated cartridge-based PCR approach ARIES SARS-CoV-2 Assay targeting the ORF-sequence and the N-gene of SARS-CoV-2.

Methods: In line with the suggestions by Rabenau and colleagues, the automated ARIES SARS-CoV-2 Assay was challenged with strongly positive samples, weakly positive samples and negative samples. Further, intra-assay and inter-assay precision as well as the limit-of-detection (lod) were defined with quantified target RNA and DNA.

Influence of body mass index and thickness of soft tissue on accuracy of ultrasound and pointer based registration in navigation of cup in hip arthroplasty.

Background: Precise identification of bony landmarks by use of pointer based navigation systems is influenced by thickness of soft tissue. Ultrasound-based navigation systems try to overcome the problems of positional deviation associated with soft tissue. The aim of the study was to investigate the influence of the BMI and the thickness of the soft tissue on the post-operative cup position and accuracy in the application of an ultrasound-based (US CAOS) and a pointer-based navigation system (P CAOS).

3D CT analysis of combined cup and stem anteversion in cases of cup navigation in hip arthroplasty.

Navigation of the cup in total hip arthroplasty is well analyzed and shows accurate results, reducing cup outliers of Lewinnek's "safe zone." With regard to the combined anteversion of cup and stem, however, a "new" safe zone with a range of 25° to 50° has been published. The aim of this study was to analyze total anteversion (cup and stem) by postoperative 3D computed tomography in isolated cup navigation cases.

Selective downregulation of phosphoinositide 3-kinase alpha in leukocytes during pregnancy.

Problem: During pregnancy, it is crucially important that the mother's immune system tolerates the developing embryo. Although a number of mechanisms of immunological tolerance have been described, little is known about intracellular signaling events, causing a decrease in the mother's leukocyte activity.

Method Of Study: We investigated the expression and activity of phosphoinositide 3-kinases (PI3K) in maternal blood cells of healthy volunteers by Reverse Transcription PCR and Western blotting.