Publications by authors named "Koen P Kemna"
Front Immunol
September 2024
Article Synopsis
- Pediatric patients with unexplained bone marrow failure are often diagnosed with aplastic anemia, and since this condition may be auto-immune, immune suppressive therapy is considered, though most severe cases are treated with hematopoietic stem cell transplantation as it offers a cure.
- A study analyzed NK- and B-cells from bone marrow and blood samples of seven pediatric AA patients compared to healthy donors, revealing specific changes in their NK-cell populations and a reduction in B-cell counts.
- The findings suggest that a subset of AA patients with reduced NK-cell function may exhibit auto-immunity, which could contribute to their condition, while transitional B-cells, believed to be regulatory in AA, were also found in lower numbers.
