Publications by authors named "Koen A J Eppenhof"

Deep learning-based methods for deformable image registration are attractive alternatives to conventional registration methods because of their short registration times. However, these methods often fail to estimate larger displacements in complex deformation fields, for which a multi-resolution strategy is required. In this article, we propose to train neural networks progressively to address this problem.

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Histological images present high appearance variability due to inconsistent latent parameters related to the preparation and scanning procedure of histological slides, as well as the inherent biological variability of tissues. Machine-learning models are trained with images from a limited set of domains, and are expected to generalize to images from unseen domains. Methodological design choices have to be made in order to yield domain invariance and proper generalization.

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Deformable image registration can be time consuming and often needs extensive parameterization to perform well on a specific application. We present a deformable registration method based on a 3-D convolutional neural network, together with a framework for training such a network. The network directly learns transformations between pairs of 3-D images.

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Error estimation in nonlinear medical image registration is a nontrivial problem that is important for validation of registration methods. We propose a supervised method for estimation of registration errors in nonlinear registration of three-dimensional (3-D) images. The method is based on a 3-D convolutional neural network that learns to estimate registration errors from a pair of image patches.

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