[A Case of Successful Multiple Surgeries for Oligometastasis from Rectal Cancer Including Diaphragmatic Metastasis].

The patient was an 81-year-old man. He underwent laparoscopic rectal resection and hepatectomy in 2 stages for Rb rectal cancer and synchronous liver metastasis, followed by adjuvant chemotherapy. One year after the hepatectomy, the cancer metastasized to liver and lung, and a second hepatectomy and right lung partial resection were performed in 2 stages, along with preoperative and postoperative chemotherapy.

Emergency laparoscopic surgery for respiratory failure caused by perforated peptic ulcer and severe scoliosis: A case report.

Introduction: Laparoscopic surgery is increasingly performed for peptic ulcer perforation, but its application in patients with severe scoliosis remains controversial due to anatomical challenges and respiratory dysfunction. We report a case of a patient with severe scoliosis who developed respiratory failure from a perforated peptic ulcer and underwent emergency laparoscopic surgery.

Presentation Of Case: A 51-year-old man was transferred to the hospital by ambulance for sudden abdominal pain.

Isolation and application to wastewater treatment of Pseudomonas sp. No. 44 possessing high formaldehyde tolerance.

Bacteria and fungi that are resistant to formaldehyde (FA) are expected to use biochemical processing to degrade FA in wastewater. Pseudomonas sp. No.

Wound, Pressure Ulcer, and Burn Guidelines-5: Guidelines for the management of lower leg ulcers and varicose veins, second edition.

"Wound, Pressure Ulcer, and Burn Guidelines-5: Guidelines for the management of lower leg ulcers and varicose veins, second edition" is revised from the first edition, which was published in the Japanese Journal of Dermatology in 2011. The guidelines were drafted by the Wound, Pressure Ulcer, and Burn Guidelines Drafting Committee delegated by the Japanese Dermatological Association and intend to facilitate physicians' clinical decisions in preventing, diagnosing and management of lower leg ulcers and varicose veins. We updated all sections by collecting documents published since the publication of the first edition.

Detoxification of hydrogen sulfide by synthetic heme model compounds.

Hydrogen sulfide is a lethal toxic gas that disrupts cellular respiration in the mitochondrial system. Currently, no antidote is available for the clinical treatment of hydrogen sulfide poisoning. In this study, we investigated the function of iron(III)porphyrin complexes as hydrogen sulfide scavengers in water and evaluated their potential use as therapeutic agents for hydrogen sulfide poisoning.

Red-light Emitting Orthogonally Trireactive Gold Nanoclusters for the Synthesis of Multifunctionalized Nanomaterials.

For the development of highly multifunctionalized nanomaterials, the introduction of functional molecules on gold nanoclusters containing thiols preinstalled with connecting groupsconstitutes a promising approach. However, the uniform introduction of multiple connecting groups while avoiding side reactions is a challenging task. Herein, the synthesis of gold nanoclusters (ca.

Chitin promotes equol production via n-acetylglucosamine in human fecal cultures.

Objectives: Equol is a metabolite of isoflavone. Here, we investigated the effect of dietary fiber on equol-producing microbiota.

Methods: Human feces was anaerobically cultured in Gifu Anaerobic Medium (GAM) containing 1 mg/L daidzein supplemented with 1 % (w/v) dietary fiber (pectin, chitin, or resistant starch [RS]).

Dicopper Complexes of -Cresol-2,6-bis(amide-tether-dpa) (X = MeO and Cl): Selective ROS Generation and Cytotoxicity Enhancement Controlled by Electronic and Hydrophobic Effects of the MeO and Cl Groups.

Two new -cresol-2,6-bis(amide-tether-dpa) ligands (HL, X = MeO and Cl) and their dicopper complexes [Cu(μ-1,1-OAc)(μ-1,3-OAc)(L)]Y (Y = PF , OAc ) and [Cu(μ-1,3-OAc)(L)]Y (Y = ClO , OAc ) were synthesized. The electronic and hydrophobic effects of the MeO and Cl groups were examined compared with nonsubstituted complex [Cu(μ-1,1-OAc)(μ-1,3-OAc)(L)] (). The electronic effects were found in crystal structures, spectroscopic characterization, and redox potentials of these complexes.

Cross-sectional study using the University of California, Los Angeles, Scleroderma Clinical Trials Consortium Gastrointestinal Tract Instrument 2.0 (UCLA SCTC GIT 2.0) for gastrointestinal disorders of systemic sclerosis.

This study aimed to identify severe gastrointestinal ailments in patients with systemic sclerosis (SSc), investigate the role of antibodies in gastrointestinal disorders, and explore the relationship between limited cutaneous SSc (lcSSc) and diffuse cutaneous SSc (dcSSc) in terms of gastrointestinal involvement and its association with skin stiffness. We used the University of California, Los Angeles, Scleroderma Clinical Trials Consortium Gastrointestinal Tract Instrument 2.0 (UCLA SCTC GIT 2.

Quantitative assessment of urinary equol levels, equol-producing bacteria, and the faecal microbiota in healthy Japanese individuals.

Equol (4',7-isoflavandiol) has attracted considerable attention for its potential efficacy in treating hormonal diseases. In this study we collected samples from healthy Japanese individuals (n = 91) to observe the relationship between the abundance of equol-producing bacteria in their faeces and the concentration of equol in their urine. Quantitative polymerase chain reaction (qPCR) targeting the dihydrodaidzein reductase gene (dhdr) was used to detect equol-producing bacteria.

Simultaneous production of hydrogen and chlorine through overall brine splitting with a particulate photocatalyst.

Sunlight-driven photocatalytic water splitting shows promise for green H production. In an attempt to achieve seawater splitting, we constructed a new stoichiometric brine splitting system that produces H along with Cl instead of O. Cl-a more potent high-value-added oxidant than O-was obtained with 100% selectivity over 10 h by adjusting the solution pH to acidic using a UV-light-driven Pt-loaded TiO photocatalyst.

GWAS for systemic sclerosis identifies six novel susceptibility loci including one in the Fcγ receptor region.

Here we report the largest Asian genome-wide association study (GWAS) for systemic sclerosis performed to date, based on data from Japanese subjects and comprising of 1428 cases and 112,599 controls. The lead SNP is in the FCGR/FCRL region, which shows a penetrating association in the Asian population, while a complete linkage disequilibrium SNP, rs10917688, is found in a cis-regulatory element for IRF8. IRF8 is also a significant locus in European GWAS for systemic sclerosis, but rs10917688 only shows an association in the presence of the risk allele of IRF8 in the Japanese population.

Clickable bisreactive small gold nanoclusters for preparing multifunctionalized nanomaterials: application to photouncaging of an anticancer molecule.

In this study, we successfully synthesized a small-sized gold nanocluster (2 nm) coated with homogeneous tripeptides bearing azido and amino groups that enable facile multifunctionalizations. Using sodium phenoxide to reduce tetrachloroauric(iii) acid in the presence of the cysteine-containing tripeptide, we efficiently prepared the gold nanoclusters without damaging the azido group. We then utilized this clickable bisreactive nanocluster as a versatile platform for synthesizing multifunctionalized gold nanomaterials.

Anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis with possible complication of thrombotic microangiopathy.

This case study illustrates a 63-year-old Japanese woman who presented with anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis. She was administered a therapeutic regimen consisting of corticosteroids, tacrolimus, and cyclophosphamide. However, after a month of treatment, symptoms of confusion and depressive tendencies emerged, followed by the manifestation of hematuria, thrombocytopenia, and fragmented erythrocytes.

Roles of DNA Target in Cancer Cell-Selective Cytotoxicity by Dicopper Complexes with DNA Target/Ligand Conjugates.

The DNA target/ligand conjugates (HL, X = P and M, = 1-3) were synthesized where various lengths of -CONH(CHCHO)CHCHNHCO- linkers with a 9-phenanthrenyl (P) or methyl (M) terminal as DNA targets replace the methyl group of 2,6-di(amide-tether cyclen)-cresol ligand (HL). DNA binding, DNA cleavage, cellular uptake, and cytotoxicity of [Cu(μ-OH)(L)](ClO) () are examined and compared with those of [Cu(μ-OH)(L)](ClO) () to clarify roles of DNA targets. Upon reaction of with HO, μ-1,1-OH complexes are formed for DNA cleavage.

Electrochemical Epoxidation Catalyzed by Manganese Salen Complex and Carbonate with Boron-Doped Diamond Electrode.

Epoxides are essential precursors for epoxy resins and other chemical products. In this study, we investigated whether electrochemically oxidizing carbonate ions could produce percarbonate to promote an epoxidation reaction in the presence of appropriate metal catalysts, although Tanaka and co-workers had already completed a separate study in which the electrochemical oxidation of chloride ions was used to produce hypochlorite ions for electrochemical epoxidation. We found that epoxides could be obtained from styrene derivatives in the presence of metal complexes, including manganese(III) and oxidovanadium(IV) porphyrin complexes and manganese salen complexes, using a boron-doped diamond as the anode.

Assessing prognostic factors correlating with response to nintedanib for connective tissue disease-associated interstitial lung disease: A real-world single-center study.

Objective: For patients with connective tissue disease-associated interstitial lung disease (CTD-ILD), early medical intervention would be desirable. This study analyzed the real-world, single-center use of nintedanib for CTD-ILD patients.

Methods: Patients with CTD who received nintedanib from January 2020 to July 2022 were enrolled.

Concordance between practice and published evidence in the management of ANCA-associated vasculitis in Japan: A cross-sectional web-questionnaire survey.

Objectives: We conducted a descriptive study of the physicians' evidence-practice gap for adults covered by the 2017 clinical practice guidelines for the management of antineutrophil cytoplasmic antibody-associated vasculitis in Japan.

Methods: This web-based survey, conducted between January and February 2021, involved physicians who had treated at least five patients in the preceding year at a regional core hospital. The outcome was the physicians' experience in treating patients with microscopic polyangiitis or granulomatosis with polyangiitis [prevalence with 95% confidence intervals (CIs)], defined as treating at least 60% of their patients with the recommended therapy during the year.

Arm heating to relieve Raynaud's phenomenon in systemic sclerosis: A single-arm multicentre prospective clinical trial.

Objectives: Raynaud's phenomenon, one of the major symptoms of systemic sclerosis (SSc), is difficult to treat. Although it is empirically considered that warming is a beneficial technique, there is no supportive evidence. We conducted a multicentre study to evaluate whether continuous heating of the arm alleviates Raynaud's phenomenon in SSc.

Preferential growth of (001)-oriented BiSiO thin films deposited on (101)-oriented rutile substrates and their ferroelectric and dielectric properties.

Ferroelectric thin films are important because of their great potential for use in various electric devices such as ferroelectric random-access memory. It was expected that BiSiO, a Si-containing ferroelectric material, would show improved ferroelectricity by targeting a film with the (001)-orientation (polar-axis) on the substrate. Although there was a narrow process window for the deposition of the (010)/(001)-oriented BiSiO thin film, it was successfully prepared on a (101)-oriented TiO single substrate using the pulsed layer deposition technique.

Safety and efficacy of rituximab in systemic sclerosis (DESIRES): open-label extension of a double-blind, investigators-initiated, randomised, placebo-controlled trial.

Background: Results from the double-blind phase 2 DESIRES trial showed that rituximab improves skin thickening in systemic sclerosis. Here, we present the findings of a subsequent 24-week open-label extension phase.

Methods: Patients with systemic sclerosis aged 20-79 years, who fulfilled the 2013 American College of Rheumatology and European League Against Rheumatism classification criteria, with a baseline modified Rodnan Skin Score (mRSS) of 10 or greater were enrolled into the DESIRES trial, which was an investigator-initiated, phase 2, double-blind, randomised controlled trial of rituximab versus placebo conducted at four sites in Japan.

Enhancement of cancer-cell-selective cytotoxicity by a dicopper complex with a phenanthrene amide-tether ligand conjugate mitochondrial apoptosis.

Dicopper complexes [Cu(μ-OH)(Ln)](ClO) [ = 1 (1) and 2 (2)] with a novel phenanthrene amide-tether ligand conjugate (HL1) and the original -cresol-2,6-bis(amidecyclen) (HL2) were synthesized. A phenanthrene unit of 1 enhances the DNA-binding by 9-fold, enabling 1 to convert supercoiled plasmid DNA with HO to a linear one in a 9.3-fold higher yield than 2.

Insights into the carbonate effect on water oxidation over metal oxide photocatalysts/photoanodes.

Photocatalytic/photoelectrochemical water splitting using metal oxide semiconductors is a promising technology for direct and simple solar-energy conversion. The addition of carbonate salts to an aqueous reaction solution has been known to promote stoichiometric O evolution and HO production HO oxidation. To elucidate the effect of carbonates, density functional theory calculations are performed to study the photoinduced HO and HCO oxidation mechanisms on TiO and BiVO.

Clinical characteristics of patients with polyarteritis nodosa based on a nationwide database in Japan.

Objectives: This study aimed to clarify the epidemiological and clinical features and treatment of patients with polyarteritis nodosa (PAN) in Japan.

Methods: We used the database of the Ministry of Health, Labour and Welfare (MHLW) of Japan in 2013 and 2014. We analysed 121 patients who were antineutrophil cytoplasmic antibodies negative among the patients certified as PAN according to the MHLW diagnostic criteria.