Publications by authors named "Kodde C"
[Vaccinations in pulmonary diseases - part 2: herpes zoste, RSV, pneumococcal infection and pertussis].
Dtsch Med Wochenschr
November 2024
Article Synopsis
- RSV is a common respiratory virus that can seriously affect newborns, infants, and older adults; two new vaccines approved in 2023 provide strong protection without the need for annual boosters.
- The 20-valent pneumococcal vaccine (PCV20) is now recommended for those over 60 and younger individuals with risk factors, replacing the older 23-valent vaccine.
- Pertussis is often overlooked in adults, with recommendations for a booster alongside tetanus shots, especially for high-risk groups; shingles (Herpes Zoster) poses risks of severe complications, particularly for those with chronic lung diseases.
Article Synopsis
- The study examines the healthcare response to SARS-CoV-2 in Germany and Switzerland, highlighting disparities in treatment and surveillance that affected patient outcomes, particularly during ICU admissions and in-hospital mortality rates.
- Using data from over 1.4 million cases across 386 German and 41 Swiss hospitals from 2019 to 2022, the research shows that German patients were older, had more comorbidities, and faced higher rates of ICU admission (28% vs. 20%) and in-hospital mortality (21% vs. 12%) compared to Switzerland.
- The findings reveal significant healthcare discrepancies between the two countries, suggesting that varying treatment approaches and healthcare resources may have influenced the higher mortality
Article Synopsis
- The study investigates the rising issue of multidrug-resistant organisms (MDRO) and the gender-specific differences in their colonization and infection patterns.
- Data was collected from 86 hospitals in Germany between 2015 and 2020, revealing that males are at a higher risk for MDRO colonization and infection compared to females.
- The findings suggest the importance of considering gender in clinical practices related to MDRO susceptibility to improve patient care and outcomes.
[Vaccinations in pulmonary diseases - part 1: Covid and influenza].
Dtsch Med Wochenschr
August 2024
SARS-COV-2 : During the COVID-19 pandemic, mRNA-based vaccines were approved for the first time. The mRNA encodes for the viral spike protein, leading to the development of specific antibodies and T-cells, providing effective protection against severe illness and death from COVID-19. New variants regularly emerge due to rapid viral evolution.
View Article and Find Full Text PDFBackground: Even though several therapeutic options are available, COVID-19 is still lacking a specific treatment regimen. One potential option is dexamethasone, which has been established since the early beginnings of the pandemic. The aim of this study was to determine its effects on the microbiological findings in critically ill COVID-19 patients.
View Article and Find Full Text PDFVaccination plays a key role in tackling the ongoing SARS-CoV-2 pandemic but data regarding the individual's protective antibody level are still pending. Our aim is to identify factors that influence antibody response following vaccination in healthcare workers. This single-center study was conducted at Evangelische Kliniken Gelsenkirchen, Germany.
View Article and Find Full Text PDFBackground: Avoiding in-hospital transmissions has been crucial in the COVID-19 pandemic. Little is known on the extent to which hospital-acquired SARS-CoV-2 variants have caused infections in Germany.
Aim: To analyse the occurrence and the outcomes of HAI with regard to different SARS-CoV-2 variants.
Purpose: At the beginning of the COVID-19 pandemic, SARS-CoV-2 was often compared to seasonal influenza. We aimed to compare the outcome of hospitalized patients with cancer infected by SARS-CoV-2 or seasonal influenza including intensive care unit admission, mechanical ventilation and in-hospital mortality.
Methods: We analyzed claims data of patients with a lab-confirmed SARS-CoV-2 or seasonal influenza infection admitted to one of 85 hospitals of a German-wide hospital network between January 2016 and August 2021.
Background: The aim of our study was to assess the impact the impact of gender and age on reactogenicity to three COVID-19 vaccine products: Biontech/Pfizer (BNT162b2), Moderna (mRNA-1273) and AstraZeneca (ChAdOx). Additional analyses focused on the reduction in working capacity after vaccination and the influence of the time of day when vaccines were administered.
Methods: We conducted a survey on COVID-19 vaccinations and eventual reactions among 73,000 employees of 89 hospitals of the Helios Group.
Article Synopsis
- - The study aimed to analyze the impact of COVID-19 on pregnant women during two waves of the pandemic, focusing on hospitalization rates, ICU admissions, and mortality among women of childbearing age.
- - A total of 1,879 women were analyzed, with 532 being pregnant; during the second wave, the percentage of pregnant women hospitalized increased significantly compared to the first wave.
- - Despite the higher number of hospitalized pregnant women in the second wave, the study found no increase in severe outcomes, such as ICU admissions or deaths, between the two waves.
Background And Aim: Biliary complications (BC) after liver transplantation (LT) are associated with significant morbidity and mortality. Incidence of BC after pediatric LT is more than 10%. In adults, treatment by endoscopic retrograde cholangiopancreaticography (ERCP) is successful.
View Article and Find Full Text PDFObjective: To assess the importance of Cryptosporidium parvum and Isospora belli infections as a cause of diarrhoea among patients admitted to the Medical Wards in Queen Elizabeth Central Hospital (QECH) in Blantyre, Malawi.
Design: Prospective case control study.
Subjects: One hundred and twenty one patients with diarrhoea and 122 patients without diarrhoea.