Publications by authors named "Kodali S"
Background: Surgery remains an important treatment for low-risk patients with severe symptomatic aortic stenosis (AS). We evaluated 5-year outcomes in low-risk patients undergoing isolated surgical aortic valve replacement (SAVR) or SAVR with concomitant procedures within the randomized PARTNER 3 trial.
Methods: In the PARTNER 3 trial, 454 patients underwent surgery for severe, symptomatic, tri-leaflet AS and were followed for 5 years.
Human pluripotent stem cells (hPSCs) exist in multiple, transcriptionally distinct states and serve as powerful models for studying human development. Despite their significance, the molecular determinants and pathways governing these pluripotent states remain incompletely understood. Here, we demonstrate that transposable elements act as sensitive indicators of distinct pluripotent cell states.
View Article and Find Full Text PDFTranscatheter Edge-to-Edge Repair in Patients With Complex Tricuspid Valve Anatomy.
JACC Cardiovasc Interv
December 2024
Article Synopsis
- Untreated severe tricuspid regurgitation (TR) is linked to poor health outcomes, making effective treatment essential.
- The study evaluated the 1-year results of transcatheter edge-to-edge repair (TEER) using the TriClip system in patients with complex tricuspid valve issues, finding significant improvements in patient survival and quality of life.
- Results showed that 81% of patients experienced a reduction in TR to moderate or less after one year, with no major adverse effects noted in the first 30 days post-procedure.
Background: The deceased donor shortage in the United States has led to increased utilization extended criteria donor (ECD) liver grafts. Centers often utilize ECD grafts in patients with low Model for End-Stage Liver Disease (MELD) scores, like patients with hepatocellular carcinoma (HCC). However, few studies have directly examined the outcomes of using ECD grafts in patients with HCC.
View Article and Find Full Text PDFTranscatheter tricuspid valve replacement (TTVR) has emerged as a promising intervention for the treatment of severe tricuspid regurgitation with complex valve morphology. This consensus document provides a comprehensive overview of the current state of orthotopic TTVR, focusing on patient selection, procedural details, and follow-up care. Clinical outcomes from initial studies and compassionate use cases are discussed, highlighting the effectiveness of TTVR in reducing tricuspid regurgitation, inducing reverse right ventricular remodeling, and enhancing patients' quality of life.
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- The study focuses on the impact of tricuspid regurgitation (TR) on heart remodeling, comparing outcomes in patients treated with the TriClip device versus those receiving standard medical therapy in a randomized controlled trial.
- Researchers utilized advanced imaging techniques, including cardiac magnetic resonance and 4D-CT, to assess heart changes at baseline, 30 days, and one year follow-ups.
- Results showed that the TriClip significantly reduced TR volume by 70% at 30 days, leading to notable reductions in right ventricular size and area, with these improvements maintained after one year, unlike the control group.
Article Synopsis
- - This study examined the effects of transcatheter aortic valve replacement (TAVR) on patients with heart failure and moderate aortic stenosis, comparing TAVR with clinical surveillance followed by valve replacement if the condition worsened.
- - A total of 178 patients were randomly assigned to either TAVR or surveillance, and results indicated that TAVR was associated with better clinical outcomes, though the statistical significance was borderline.
- - TAVR led to a more substantial improvement in heart failure symptoms, as measured by the Kansas City Cardiomyopathy Questionnaire, compared to the surveillance group after one year of follow-up.
Article Synopsis
- Severe tricuspid regurgitation (TR) significantly impacts patients' health status, affecting their symptoms, physical and social functions, and overall quality of life, but may improve with a procedure called transcatheter tricuspid valve replacement (TTVR).
- The TRISCEND II trial studied 400 patients with severe TR, comparing outcomes of those receiving TTVR combined with optimal medical therapy (OMT) to those receiving OMT alone, using established health status questionnaires.
- Results showed that patients receiving TTVR+OMT experienced significantly greater improvements in health status at every follow-up, with notable differences in scores indicating enhanced quality of life compared to those who only received
Article Synopsis
- A clinical trial was conducted with 400 patients suffering from severe tricuspid regurgitation, comparing outcomes between those who received transcatheter tricuspid-valve replacement alongside medical therapy and those who received medical therapy alone.
- The primary outcome measured included death rates, hospitalizations due to heart failure, and improvements in quality of life and functional capacity, showing a significant advantage for the valve-replacement group.
- After one year, the valve-replacement group demonstrated better overall health outcomes, although there was a higher incidence of severe bleeding compared to the control group.
Purpose Of Review: Transplant oncology encompasses and utilizes liver transplantation (LT) in combination with other aspects of cancer care to offer improved long-term outcomes for patients with liver cancer, but not all patients have equal access and ability to undergo LT. Social determinants of health may negatively impact a patient's ability to receive liver-related oncologic care, including LT. This review highlights recent work exposing gaps in access to LT, including transplant oncology, and interventions to ameliorate these disparities.
View Article and Find Full Text PDFObjective: To evaluate the outcomes of transcatheter edge-to-edge repair (TEER) with MitraClip™ (Abbott Vascular) in symptomatic high surgical risk Indian patients with significant mitral regurgitation (MR).
Methods: Patients with moderately severe or severe primary or secondary MR and deemed high surgical risk were treated with MitraClip™. The data were collected retrospectively from medical records.
EVOQUE Tricuspid Valve Replacement System: State-of-the-Art Screening and Intraprocedural Guidance.
JACC Cardiovasc Interv
September 2024
Article Synopsis
- The transcatheter EVOQUE tricuspid valve replacement system has been recently approved for treating severe tricuspid regurgitation, highlighting the importance of identifying suitable patients and their anatomical features.
- The document outlines necessary procedural steps and imaging techniques that facilitate successful implementation of the device.
- It also addresses how to manage complex situations that may arise during the procedure.
Valve-in-valve transcatheter aortic valve replacement for failed Perceval sutureless valves has been shown to be safe and feasible. However, it is technically challenging and warrants understanding of potential risks and complications. We present a case of successful valve-in-valve implantation complicated by inadvertent wire passage outside of the Perceval frame.
View Article and Find Full Text PDFThe ten-eleven translocation (TET) family of dioxygenases maintain stable local DNA demethylation during cell division and lineage specification. As the major catalytic product of TET enzymes, 5-hydroxymethylcytosine is selectively enriched at specific genomic regions, such as enhancers, in a tissue-dependent manner. However, the mechanisms underlying this selectivity remain unresolved.
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- Tricuspid regurgitation (TR) is common in patients undergoing transcatheter aortic valve replacement (TAVR), but specific management guidelines are not clearly defined.
- A study analyzed data from over 312,000 TAVR patients, finding that severe TR correlated with higher mortality rates both in-hospital and at one and three years post-procedure.
- The research also indicated that a significant number of patients (76.4%) with severe TR improved after TAVR, and several factors predicted this improvement, although ongoing severe TR was linked to increased mortality.
The global surge in refractive surgeries, particularly among myopic individuals, has elicited concerns regarding potential inaccuracies in the measurement of intraocular pressure (IOP) post surgery, primarily associated with central corneal thinning. The incidence of elevated IOP after intraocular refractive surgeries is higher than expected and is multifactorial. Myopic eyes have a higher susceptibility to both primary and secondary glaucoma.
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- Post-transcriptional mechanisms play a vital role in maintaining progenitor cell identity and can be disrupted in cancer, particularly in acute myeloid leukemia (AML).
- Researchers used CRISPR screens to discover that regulators of P-bodies, which are cellular structures involved in RNA processing, are essential for the development and upkeep of AML.
- The study shows that while P-body loss minimally affects normal blood cell production, it significantly alters the behavior of leukemia cells by releasing tumor suppressor mRNAs, leading to changes in gene expression and potential new treatment strategies for myeloid leukemia.
Article Synopsis
- Limited data on strain changes after TAVI in patients with aortic regurgitation (AR) was explored in this study.
- Three patients experienced an initial decrease in global longitudinal strain (GLS) after TAVI, but showed significant improvement within the first year.
- The results suggest that GLS may be a better indicator than left ventricular end-diastolic diameter ratio for evaluating patients with severe volume overload.
Article Synopsis
- * Results indicate high procedural success (96.6%) and relatively low mortality rates, with 1-year all-cause mortality being 13.4%. Improvements in patient functional class and quality of life were also observed post-procedure.
- * Over the study period, there was a notable increase in the number of MViV procedures, coupled with reduced procedure times and hospital stays, highlighting advancements in the technique and
Article Synopsis
- New postprocessing software enables 3D echocardiographic assessment of mitral annular and neo-left ventricular outflow tract dimensions in patients undergoing transcatheter mitral valve replacement.
- This study compares the accuracy of 3D echocardiographic analysis to that of baseline computed tomography in these measurements among 105 patients.
- Results show TEE underestimates mitral annular dimensions but gives comparable predictions for neo-LVOT area and peak gradients when compared to CT measurements.
Article Synopsis
- 3D intracardiac echocardiography (ICE) is becoming a valuable alternative to transesophageal echocardiography for guiding heart procedures, particularly in structural heart interventions.
- The expert position statement outlines standardized practices for using 3D-ICE, detailing necessary imaging fundamentals, views, and workflows for various procedures like transeptal puncture and device closures.
- Additionally, the paper addresses current challenges, potential future developments, and training needs to ensure that operators are proficient with 3D-ICE, aiming to enhance its safety and effectiveness in clinical settings.
Article Synopsis
- Augmented reality (AR) can enhance transcatheter aortic valve replacement (TAVR) procedures by providing visualization of 3D patient-specific anatomical models, potentially increasing safety and efficiency during the placement of cerebral embolic protection devices (CEP).
- A study involving 24 patients compared those using AR guidance to a control group, finding that AR guidance significantly reduced the contrast volume needed for the procedure while not affecting the time taken for filter placement or fluoroscopy.
- Postprocedure feedback from physicians indicated that AR guidance boosted their confidence in performing the procedure, suggesting it improved overall intervention performance despite similar procedural times.
A host of medical conditions, including amputations, diabetes, stroke, and genetic disease, result in loss of touch sensation. Because most types of sensory loss have no pharmacological treatment or rehabilitative therapy, we propose a haptic sensory prosthesis that provides substitutive feedback. The wrist and forearm are compelling locations for feedback due to available skin area and not occluding the hands, but have reduced mechanoreceptor density compared to the fingertips.
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- Severe tricuspid regurgitation is often inadequately treated due to a lack of effective options, but transcatheter tricuspid valve interventions are gaining attention as a potential solution.
- The TRISCEND II pivotal trial is the first randomized controlled trial to assess the safety and effectiveness of the EVOQUE transcatheter tricuspid valve replacement system, which received FDA Breakthrough Device Designation.
- This trial has a unique two-phase design that allows for early analysis of patient outcomes, helping to set a standard for future research in transcatheter valve devices.