Publications by authors named "Kodagahalli Sathya Rakesh"
Inflammation
February 2016
Article Synopsis
- Arachidonic acid metabolism by lipoxygenase (LOX) and cyclooxygenase (COX) plays a significant role in inflammation and cancer, particularly through the production of leukotrienes and prostaglandins that fuel tumor growth.
- Researchers synthesized isoxazole derivatives to target LOX and COX for their anti-inflammatory effects, with compound 2b demonstrating the strongest inhibition of these enzymes.
- Compound 2b also effectively reduced tumor growth and associated issues in a mouse model, along with promising binding affinity to LOX and COX enzymes, suggesting its potential as an anti-inflammatory and anticancer drug.
