[Clinical efficacy of using ximedon in surgical practice].

Results of clinical trial of the new pyrimidine derivative--ximedone are presented. The drug was administered per os 0.5 g x 4 times a day (0.

[Laparoscopic cholecystectomy: possibilities, shortcomings, prospects].

The results of surgical treatment of acute cholecystitis in 350 patients have been analysed. The role of concomitant diseases and age of a patients in choosing the method of surgical treatment is stressed. The advantages and shortcomings of the low-traumatic surgical methods are discussed.

[Comparative assessment of methods of extracorporeal detoxication in obstructive jaundice].

Comparative analysis of the methods of extracorporeal detoxification in 168 patients was conducted. Endoscopic and surgical methods of treatment were applied in 40 patients without extracorporeal detoxification. Various types of extracorporeal detoxification were used along with endoscopic and operative methods in 168 patients: plasmapheresis (PP) in 72, thoracic duct (TD) drainage in 45, and hemosorption in 41 patients.

[Device for wound debridement].

A device for prevention of wound infection in emergency surgery is suggested. It is distinguished by its funnel having an elastic prolongation in the form of a porolone "skirt". The openings on the funnel have the shape of a truncated cone positioned at an angle to the axis of the device and directed at the center.

[Determination of antimicrobial activity of wound discharge for assessing wound healing].

The authors studied the dynamics of changes of antimicrobial activity of the wound discharge in 70 patients, aged from 18 to 83 years, who underwent operations for emergency diseases of the abdominal organs with postoperative suppuration of the wound. The study was conducted at the peak of suppuration, in the regeneration phase, and before closure of the wound with sutures. The antimicrobial activity of the wound discharge was found to be low at the peak of wound suppuration with marked necrotic changes of the tissues, as well as in poor granulations, and good in uncomplicated course of the wound process.

[Physico-chemical parameters of bile in evaluating the course of an inflammatory process in the biliary tract].

Bile electric conductivity and pH were studied in dynamics in 165 patients with acute cholecystitis. The bile was obtained from drains of the gallbladder, choledochus and its terminal part and from percutaneous-transhepatic cholangiostoma. The results of the study proved that the combined changes of the mentioned physicochemical parameters of the bile are determined by the course of the inflammatory process in the biliary tract and pancreas and by the degree of hepatic functional insufficiency.

[Auto-dermal monophilic plastic surgery of ventral hernia].

To improve the results of surgical management of postoperative ventral hernias, the authors applied their suggested variant of autodermic plasty of the hernial openings. The method consists in using for the plasty a band or graft of autologous skin armored with a monophilic thread. To reduce lymphorrhea the autodermic graft was covered with a hernial sac on a pedicle.

[The use of xymedon for wound healing stimulation and prevention of suppuration of surgical wounds].

Xymedon, a new preparation of the pyrimidine series, was studied in experiment and in the clinic. Experiments showed that on the 5th postoperative day the tensile strength of the scar was greater by 57% and the elasticity strength was greater by 21.5% in animals given Xymedon that in the control animals; the tensile strength was 42.

[The effect of xymedon on healing of linear wounds].

In the experiment on 173 rats the stimulating effect of xymedon on the processes of reparative regeneration in a wound was established. This effect manifests itself in increasing the elasticity and strength of the cicatricial tissue. The use of xymedon in the clinic permitted to improve the course of postoperative period in patients with uncomplicated forms of acute appendicitis and reduce the incidence of complications of the wound healing.

[Mechanical jaundice: laparotomy or endoscopy?].

The results of diagnosis and surgical and endoscopic treatment in 285 patients with jaundice are analysed. The diagnostic-therapeutic tactics were divided into 3 periods. In the first period the diagnosis was based on the clinical findings and the results of laboratory biochemical tests.

[Causes of recurrence of pain in patients after cholecystectomy and its treatment].

The authors analysed the results of diagnosis and treatment of the postcholecystectomy syndrome in 131 patients. Recurrence of biliary colic after cholecystectomy is linked in most patients with functional disorders of the sphincter of Oddi (27.4%) which disappear in many cases after cholecystectomy.