Publications by authors named "Kochli Channappa Niranjan"
Article Synopsis
- Oral verrucous lesions (OVLs) are challenging to diagnose due to varying histopathological features, and this study investigates Mcm-2 and Ki-67 as markers to help differentiate these lesions from oral squamous cell carcinoma (OSCC).
- Using 90 paraffin-embedded tissue samples, the researchers assessed the expression levels of Mcm-2 and Ki-67, alongside patient survival data, employing statistical methods for analysis.
- Findings revealed that Mcm-2 is a more sensitive and prognostic indicator than Ki-67, with higher overexpression in verrucous lesions and improved survival rates in verrucous squamous cell carcinoma (VSCC) compared to conventional OSCC, suggesting its potential for better diagnosis
Objectives: Tumor budding is a sign of invasion and early step for metastasis of many cancers including oral squamous cell carcinoma (OSCC). Evidences suggest the presence of cancer stem cells in tumor buds. CD44 has been reported in tumor growth and metastasis as a cancer stem cell marker in OSCC.
View Article and Find Full Text PDFBackground: Several prognostic indicators have been used for many decades in an attempt to predict clinical behaviour of Oral Squamous Cell Carcinoma (OSCC). The prognostic value of TSR is yet to be explored in OSCC. Hence, the aim of the present study was to evaluate the prognostic value of TSR in OSCC patients.
View Article and Find Full Text PDFBackground: Mcm-2 is a biomarker belonging to Mcm family of proteins which has rarely been used in oral potentially malignant and malignant lesions of the verrucous type. The objective of this study is to assess the expression of Mcm-2 in Normal Oral Mucosa (NM), Verrucous Hyperplasia (VH), Verrucous Carcinoma (VC) and Oral Squamous Cell Carcinoma (OSCC) and compare it with the clinicopathological characteristics.
Methodology: A total of 70 formalin fixed paraffin embedded tissue samples (10 cases of Normal Mucosa NM- Group A, 10 cases of Verrucous Hyperplasia- VH without Dysplasia- Group B, 10 cases of Verrucous Hyperplasia- VH with Dysplasia- Group C, 20 cases of Verrucous Carcinoma VC-Group D, 20 cases of Oral Squamous Cell Carcinoma OSCC- Group E) were subjected to immunohistochemistry with Mcm-2 antibody.
Introduction: Cyclin B1 is important in the cell cycle progression from G2 to M phase. Cyclin B1 binds to CDC2, which then becomes dephosphorylated and gets relocated to the nucleus, ensuring the transition toward mitosis.
Aim: Over expression of Cyclin B1, has been reported more recently in breast, colon, prostate, oral and esophageal carcinomas.