[Clinical and epidemiological aspects of neuromyelitis optic spectrum diseases in the russian population].

Objective: To present clinical and epidemiological aspects of neuromyelitis optica spectrum disorders (NMOSD) in the Russian Federation.

Material And Methods: We studied 142 patients who met diagnostic criteria of 2015 for NMOSD. Sex, age at disease onset, presence or absence of aquaporin-4 immunoglobulin G antibodies (AQP4-IgG), mail clinical symptoms, oligoclonal IgG, therapy for the treatment of exacerbations and prevention of exacerbations, compliance with 2006 diagnostic criteria were assessed.

[Monoclonal antibody therapies for rapidly progressive and highly active multiple sclerosis in the era of the COVID-19 pandemic].

As the COVID-19 pandemic continues, reducing the risk of infection for immunocompromised patients remains an important issue. Patients with aggressive multiple sclerosis (MS) require immunosuppressive therapy in order to control the overactive autoimmune response. Preliminary international and national trials demonstrate that older age, higher disability status and progressive MS are generally associated with a more severe clinical course of COVID-19.

C9orf72 Gene Expression in Frontotemporal Dementia and Amyotrophic Lateral Sclerosis.

We studied the expression of C9orf72 gene in pathologies associated with hexanucleotide repeats expansion in this gene: frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). The study included 7 patients with hexanucleotide repeats expansion in the C9orf72 gene and 9 patients of the control group. The expression of C9orf72 mRNA was evaluated in blood leukocytes by real-time PCR.

[Experience in designing an electronic multiple sclerosis registry].

Objective: To develop an electronic registry of patients with MS in the Russian Federation and to analyze the collected epidemiological and clinical data.

Materials And Methods: Patients aged 18 and older with definite multiple sclerosis were included in the study. We designed a specialized electronic individual registration form (registry) to gather information about study participants.

[Leptomeningeal B-cell follicles in multiple sclerosis: a role in the pathogenesis and prognostic value].

B-lymphocytes play an important role in the development and maintenance of the inflammatory process in multiple sclerosis. Recently special attention has been paid to cell formations that are found in the meninges in patients with multiple sclerosis - the so-called leptomeningeal follicle-like structures that contain not only B-lymphocytes, but also other immunocompetent cells, creating a special environment for clonal expansion, selection and further proliferation of B-lymphocytes. Magnetic resonance imaging (MRI) of the brain with gadolinium-based contrast agents reveals local subarachnoid space contrasting that corresponds to the accumulation of the contrast agent by large lymphoid follicles.

Effect of Mutations in SOD1 and C9orf72 Genes on Autophagy in Lymphomonocytes in Myotrophic Lateral Sclerosis.

Insoluble protein inclusions accumulate in somatic cells in amyotrophic lateral sclerosis. The most common gene mutations associated with this pathology are SOD1 and C9orf72. Protein aggregates can be removed from cells by autophagy.

[Diagnostic value of antibodies to myelin oligodendrocyte glycoprotein in demyelinating diseases of the central nervous system].

Aim: To evaluate the diagnostic value of MOG-IgG antibodies in multiple sclerosis (MS) and acute disseminated encephalomyelitis (ADEM).

Material And Methods: Twenty-nine patients with definitive MS according to the criteria of McDonald, 2010 (21 with relapse-remitting MS and 8 with secondary progressive MS), 7 patients with ADEM confirmed by clinical and instrumental data and 27 healthy volunteers were included in the study. Serum MOG-IgG levels were evaluated in all patients.

[The application of high-frequency and iTBS transcranial magnetic stimulation for the treatment of spasticity in the patients presenting with secondary progressive multiple sclerosis].

Unlabelled: Spasticity is considered to be a common manifestation of multiple sclerosis. Muscle relaxants are not sufficiently effective; more than that, some of them often cause a variety of adverse reactions. Transcranial magnetic stimulation (TMS) can be a promising new tool for the treatment of spasticity.

[TECHNOLOGIES FOR THE APPLICATION OF NATURAL HEALING FACTORS (THERAPEUTIC MUDS, MINERAL WATER) IN CHILDREN WITH THE PATHOLOGY OF HEPATOBILIARY SYSTEM RESIDING IN UNFAVORAUBLE ECOLOGICAL CONDITIONS].

Health of children residing in the regions with polluted environment is significantly worse than the health of children not exposed to the emissions of industrial enterprises and motor vehicles. The gastrointestinal tract diseases occupy first places. There is elaborated the comprehensive treatment of the children with hepatobiliary diseases residing in unfavorable ecological conditions.

[Heath status and level of adaptation in workers of the aluminium industry and technologies of the restorative medicine].

The results of the research of states of adaptation and health in workers of the aluminum industry are provided. Functional connection of the level of adaptability in respect of the parameter of adaptation (AP) with the length of employment has been revealed. The technologies of rehabilitative treatment under the conditions of the chronic fluoric intoxication have been presented.

[Chronopathology and chronotherapy of chronic pancreatitis].

Circadian rhythms of cardiovascular system vegetative provision, indices of rheohepatography and pancreas exocrine function of 417 patients with chronic pancreatitis were studied. Signs of desynchronosis were registered in more than one third of the cases. Presence of vibration disease leads to escalation of negative processes of desynchronosis.

[Daily variation of some cardiovascular parameters in healthy children and in those with chronic cholecystitis, changes on mud cure].

Studies covered chronologic algorithm of physiologic parameters in healthy children and those with hepato-biliary diseases. 71.3% of children suffering from hepato-biliary diseases appeared to have significant desynchronization.

[Low-mineral water and sapropel in the treatment of chronic cholecystitis in children in conditions of polluted environment].

The comparison of the course of chronic cholecystitis in children living in healthy and polluted regions of the Chelyabinsk Territory has demonstrated that industrial enronmental pollution deteriorates the course of chronic cholecystitis. Drinking of low-mineral water and sapropel application on hepatic area improved clinical parameters in the examinees.

[Prevention therapy of occupationally conditioned maladaptions in workers].

Medical examinations of workers with long length of service and subsequent biorhythmologic research revealed increased disorders in structure of temporal coordination of physiologic functions. Efficiency of suggested variants of correction therapy is supported by long working experience of sanatoriums and preventoriums.