Acute radiation-induced skin toxicity in hypofractionated vs. conventional whole-breast irradiation: An objective, randomized multicenter assessment using spectrophotometry.

Purpose: Radiation dermatitis represents one of the most frequent side effects in breast cancer patients undergoing adjuvant whole-breast irradiation (WBI). Whether hypofractionated WBI induces comparable or less acute radiation-induced skin reactions than conventional WBI is still not fully clarified, as randomized evidence and objective assessments are limited. The aim of this study was to objectively determine frequency and severity of acute radiation-induced skin reactions during hypofractionated vs.

Syndapin I Loss-of-Function in Mice Leads to Schizophrenia-Like Symptoms.

Schizophrenia is associated with cognitive and behavioral dysfunctions thought to reflect imbalances in neurotransmission systems. Recent screenings suggested that lack of (functional) syndapin I (PACSIN1) may be linked to schizophrenia. We therefore studied syndapin I KO mice to address the suggested causal relationship to schizophrenia and to analyze associated molecular, cellular, and neurophysiological defects.

Reply to the 'Comment on "Revisiting π backbonding: the influence of d orbitals on metal-CO bonds and ligand red shifts"' by G. Frenking and S. Pan, , 2019, 22, DOI: 10.1039/C9CP05951B.

We respond to the comment by Pan and Frenking with regard to our investigation on transition and alkaline earth metal d orbital influence on their bonding to carbonyl ligands to clarify misconceptions. We do not consider the points raised in the comment as affecting our conclusions.

Reply to the 'Comment on "Revisiting π backbonding: the influence of d orbitals on metal-CO bonds and ligand red shifts"' by G. Frenking and S. Pan, Phys. Chem. Chem. Phys., 2019, 22, DOI.

We respond to the comment by Pan and Frenking with regard to our investigation on transition and alkaline earth metal d orbital influence on their bonding to carbonyl ligands to clarify misconceptions. We do not consider the points raised in the comment as affecting our conclusions.

Hydraulic analysis of a meander on the Danube River using a 2D flow model.

This paper presents the development, calibration and verification of a two-dimensional model for a Danube reach and its old cutoff meander. The considered meander was at one point separated from the main reach with a levee, which caused a series of unwanted environmental consequences. Aiming to stop the ongoing degradation of the meander, the validated model was engaged to investigate the effects different river works would have on its current state.

What Are They Worth? Six 30-Day Readmission Risk Scores for Medical Inpatients Externally Validated in a Swiss Cohort.

Background: Several clinical risk scores for unplanned 30-day readmission have been published, but there is a lack of external validation and head-to-head comparison.

Objective: Retrospective replication of six clinical risk scores (LACE, HOSPITAL, SEMI, RRS, PARA, Tsui et al.)f DESIGN: Models were fitted with the original intercept and beta coefficients as reported.

Hydrofilm Polyurethane Films Reduce Radiation Dermatitis Severity in Hypofractionated Whole-Breast Irradiation: An Objective, Intra-Patient Randomized Dual-Center Assessment.

Radiation-induced skin injury represents the most frequent side effect in breast cancer patients undergoing whole-breast irradiation (WBI). Numerous clinical studies on systemic and topical treatments for radiation dermatitis have failed to provide sustainable treatment strategies. While protective skin products such as dressings are undoubtedly the standard of care in wound care management, their utilization as preventive treatment in radiotherapy has been somewhat neglected in recent years.

Changes in meta-transcriptome of rumen epimural microbial community and liver transcriptome in young calves with feed induced acidosis.

The common management practices of dairy calves leads to increased starch concentration in feed, which subsequently may cause rumen acidosis while on milk and during weaning. Until recently, few attempts were undertaken to understand the health risks of prolonged ruminal acidosis in post weaning calves. Resultantly, the molecular changes in the digestive tracts in post-weaning calves with ruminal acidosis remain largely unexplored.

Use of misoprostol in the treatment of postpartum hemorrhage: a pharmacoepidemiological approach.

Objective: To characterize the use of the drug misoprostol for treatment of postpartum hemorrhage in pregnant women.

Methods: A descriptive observational study was carried out with secondary data from pregnant women who used misoprostol to treat postpartum hemorrhage in a reference public maternity, from July 2015 to June 2017. Clinical and sociodemographic profiles of pregnant women, how misoprostol was used and success rate in controling postpartum hemorrhage were characterized.

BiMM forest: A random forest method for modeling clustered and longitudinal binary outcomes.

Clustered binary outcomes and datasets with many predictor variables are frequently encountered in clinical research (e.g. longitudinal studies).

Ankyrin repeat-containing N-Ank proteins shape cellular membranes.

Cells of multicellular organisms need to adopt specific morphologies. However, the molecular mechanisms bringing about membrane topology changes are far from understood-mainly because knowledge of membrane-shaping proteins that can promote local membrane curvatures is still limited. Our analyses unveiled that several members of a large, previously unrecognised protein family, which we termed N-Ank proteins, use a combination of their ankyrin repeat array and an amino (N)-terminal amphipathic helix to bind and shape membranes.

Revisiting π backbonding: the influence of d orbitals on metal-CO bonds and ligand red shifts.

The concept of π backbonding is widely used to explain the complex stabilities and CO stretch frequency red shifts of transition metal carbonyls. We theoretically investigate a non-transition metal 18-electron carbonyl complex (Mg(CO)) and find a pronounced CO red shift without metal-carbon π bonds. Moreover, we use truncated basis sets on the "honorary" and true transition metals Ca and Ti in Ca(CO) and [Ti(CO)] complexes to probe the influence of d functions on carbonyl complex stability, C-O bond strength, metal-to-ligand charge transfer and bond order compared to hypothetical complexes without metal-d contributions.

Evaluation of total keratometry and its accuracy for intraocular lens power calculation in eyes after corneal refractive surgery.

Purpose: To compare the accuracy of total keratometry (TK) and standard keratometry (K) from a swept-source optical coherence tomography biometer for intraocular lens (IOL) power calculation in eyes with previous corneal refractive surgery.

Setting: Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, USA.

Design: Retrospective case series.

Decision-Making Deficits in Elderly Can Be Alleviated by Attention Training.

Decision-making is an important everyday function that deteriorates during normal aging. Here, we asked whether value-based decision-making can be improved in the elderly by cognitive training. We compared the effects of two training regimens on the performance in the Iowa Gambling Task (IGT), a real-life decision-making simulation task.

Diagnostic and prognostic value of the D-dimer test in emergency department patients: secondary analysis of an observational study.

Background D-dimer measurement improves the rule-out of thromboembolic disease. However, little is known about the risk of false positive results for the diagnosis of thromboembolic disease and its prognostic value. Herein, we investigated factors influencing the accuracy of D-dimer and its prognostic value in a large cohort of emergency department (ED) patients.

Results from the United States cohort of the HORIZON trial of a Schlemm canal microstent to reduce intraocular pressure in primary open-angle glaucoma.

Purpose: To assess the safety and effectiveness of Schlemm canal stenting for reducing intraocular pressure (IOP) in combination with cataract surgery in the United States cohort of the HORIZON study.

Setting: Twenty-six clinical sites in the U.S.

Validation of a Prediction Rule for Pneumonia in Emergency Department Patients.

We validated a clinical prediction rule for based on clinical parameters (dry cough, fever) and laboratory findings (C-reactive protein, lactate dehydrogenase, sodium, platelet counts) in 713 consecutive patients with community-acquired pneumonia. The Score performed well in estimating the likelihood for infection and thus may help to direct diagnostic and therapeutic decisions.

Does Lidocaine Cause False Positive Results on Cocaine Urine Drug Screen?

Background: Individuals who have tested positive for cocaine have claimed that lidocaine, or its primary metabolite, norlidocaine (monoethylglycinexylidide (MEGX)), have caused false positive results for the cocaine metabolite benzoylecgonine (BE) on urinary immunoassay testing.

Objective: The goal of the study was to determine if lidocaine exposure from routine medical procedures can result in false positives on a commercially available cocaine immunoassay urine drug screen (UDS).

Methods: We performed a cross-sectional observational study of patients receiving lidocaine as part of their regular care.

[Do the new molecular assays-microarray and realtime polymerase chain reaction-for dermatophyte detection keep what they promise?].

In this study, a novel real-time polymerase chain reaction (PCR) assay (DermaGenius®2.0, PathoNostics BV, Maastricht, The Netherlands) and a recently developed microarray test (EUROArray Dermatomycosis, Euroimmun, Lübeck, Germany) were evaluated regarding their diagnostic specificity to identify dermatophyte DNA. The tests were compared to conventional methods and sequencing.

Total body irradiation: Significant dose sparing of lung tissue achievable by helical tomotherapy.

Purpose: Total body irradiation (TBI) is an important procedure in the conditioning for bone marrow and hematopoietic stem cell transplantation. Doses up to 12Gy are delivered in hyperfractionated regimes. TBI performed with helical Tomotherapy® (Accuray, Madison, Wisconsin, USA) is an alternative to conventional techniques to deliver dose in extended target volumes with the possibility of simultaneous dose sparing to organs at risk.

Prospective randomized investigation of topical anesthesia during unilateral laparoscopic ovariectomy in horses.

Objective: To compare pain-related responses in mares receiving topical or injected anesthesia of the ovarian pedicle prior to standing unilateral laparoscopic ovariectomy.

Study Design: Prospective randomized, blinded, placebo-controlled study.

Animals: Fifteen healthy research mares.