De-Escalation of Nodal Surgery in Clinically Node-Positive Breast Cancer.

Importance: Increasing evidence supports the oncologic safety of de-escalating axillary surgery for patients with breast cancer after neoadjuvant chemotherapy (NAC).

Objective: To evaluate the oncologic outcomes of de-escalating axillary surgery among patients with clinically node (cN)-positive breast cancer and patients whose disease became cN negative after NAC (ycN negative).

Design, Setting, And Participants: In the NEOSENTITURK MF-1803 prospective cohort registry trial, patients from 37 centers with cT1-4N1-3M0 disease treated with sentinel lymph node biopsy (SLNB) or targeted axillary dissection (TAD) alone or with ypN-negative or ypN-positive disease after NAC were recruited between February 15, 2019, and January 1, 2023, and evaluated.

ASO Author Reflections: Nodal Recurrence Is Rare in Patients with cN+/ycN0 Breast Cancer after Neoadjuvant Chemotherapy Regardless of the Extent of Axillary Surgery or Nodal Pathology in the NEOSENTITURK-Trials MF18-02/18-03 Provided Regional Nodal Irradiation Is Administered.

The combined analysis of the retrospective multicentre and prospective multicenter cohort registry trial NEOSENTITURK MF18-02/18-03 (NCT04250129) investigated the outcomes and factors associated with recurrence in patients with cT1-4N1-3M0 who underwent a succesful sentinel lymph node biopsy or targeted axillary dissection (n = 1470), with or without axillary lymph node dissection (n = 937) after neoadjuvant chemotherapy. The present large registry data suggest that axillary recurrences (AR) can be detected at exceedingly low rates (< 0.5%) within 3 years after surgery.

Breast Cancer Recurrence in Initially Clinically Node-Positive Patients Undergoing Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy in the NEOSENTITURK-Trials MF18-02/18-03.

Background: This study aims to identify factors predicting recurrence and unfavorable prognosis in cN+ patients who have undergone sentinel lymph node biopsy (SLNB) following neoadjuvant chemotherapy (NAC).

Methods: The retrospective multi-centre "MF18-02" and the prospective multi-centre cohort registry trial "MF18-03" (NCT04250129) included patients with cT1-4N1-3M0 with SLNB+/- axillary lymph node dissection (ALND) post-NAC.

Results: A total of 2407 cN+ patients, who later achieved cN0 status after NAC and subsequently underwent SLNB, were studied.

Investigation of the alterations in miRNA expression levels in thyroid nodules and malignancies.

The relationship between preoperative miR-146b and miR-155 expression levels and postoperative pathology results in patients operated on for nodular thyroid disease and thyroid malignancy was investigated. Sixty three patients who were operated on for thyroid nodules diagnosed as benign, malignant and atypia of undetermined significance (AUS) were included in the study. Preoperative miR-146b and miR-155 expression levels of these patients were compared according to postoperative pathology results.

A novel index to predict postoperative hypocalcemia in primary hyperparathyroidism.

Bakground: Vitamin D (Vit D) deficiency is common in patients with hyperparathyroidism, but the importance of replacement before surgery is controversial. It can be predicted that hypocalcemia risk will be higher in patients with high bone turnover.

Aim: In this study, the effect of preoperative ALP/Vit D ratio on postoperative hypocalcemia was investigated.

Effect of the MiR-99b and MiR-135b on peritoneal carcinomatosis and liver metastasis in colorectal cancer.

Aim: This study aimed to evaluate the expression levels of miR-99b and miR-135b in peritoneal carcinoma and liver metastases associated with Colorectal Cancer (CRC), assess their association with the intracellular signaling pathway proteins Kirsten Rat Sarcoma Virus (KRAS) and Akt, and investigate their effects on survival.

Materials And Methods: Changes in the KRAS gene and Akt proteins, expression levels of miR-99b and miR-135b, and factors affecting survival were compared between colorectal cancer-associated peritoneal carcinomatosis and liver metastasis.

Results: The expression levels of miR-99b and miR-135b and the immunohistochemical grade classification score of Akt were higher in colorectal cancer, peritoneal carcinomatosis, and liver metastasis than in normal tissues (p < 0.

Phase-change Fano resonator for active modulation of thermal emission.

Optical modulation of heat emission using spectrally selective infrared (IR) metasurface nanoantenna designs has found potential applications in various fields, including radiative cooling and thermal camouflage. While radiative cooling requires emitters to emit within atmospheric transmissive windows (mainly located at 8-14 μm), thermal camouflage structures have to operate within the non-transmissive window (5-8 μm) to hide an object from thermal imaging systems and cameras. Therefore, a passive nanoantenna structure cannot satisfy both conditions simultaneously.

CNN-based deep learning method for predicting the disease response to the Neoadjuvant Chemotherapy (NAC) treatment in breast cancer.

Objective: The objective of the study is to evaluate the performance of CNN-based proposed models for predicting patients' response to NAC treatment and the disease development process in the pathological area. The study aims to determine the main criteria that affect the model's success during training, such as the number of convolutional layers, dataset quality and depended variable.

Method: The study uses pathological data frequently used in the healthcare industry to evaluate the proposed CNN-based models.

Deep Learning Based Egg Fertility Detection.

This study investigates the implementation of deep learning (DL) approaches to the fertile egg-recognition problem, based on incubator images. In this study, we aimed to classify chicken eggs according to both segmentation and fertility status with a Mask R-CNN-based approach. In this manner, images can be handled by a single DL model to successfully perform detection, classification and segmentation of fertile and infertile eggs.

The prognostic and predictive values of differential expression of exosomal receptor tyrosine kinases and associated with the PI3K/AKT/mTOR signaling in breast cancer patients undergoing neoadjuvant chemotherapy.

Purpose: Cancer cell-derived exosomes are the mediator of the tumor microenvironment and the molecular content of exosomes presents a promising prognostic or predictive marker in tumor progression and the treatment response of cancer patients. The aim of this study was to identify the expression levels of receptor tyrosine kinases (RTKs) and AKT1 and mTOR before and after neoadjuvant chemotherapy (NACT) in the exosomes of BC patients compared with healthy females.

Methods: After isolating exosomes in the serum of 25 BC patients and characterization by flow cytometry, the mRNA levels of FGFR2, FGFR3, PDGFRB, AKT1 and mTOR in the exosomes were analyzed by RT-PCR.

The Relationship Between Mammographic Density and Factors Affecting Breast Cancer Risk.

Objectives: Although the relationship between breast cancer (BC) risk factors and mammographic density (MD) patterns is not clear, high MD is well known as an independent risk factor for BC. Thus, the aim of this study was to examine the association between MD and BC risk factors in BC patients and find a correlation between MD and tumor characteristics in BC patients.

Methods: Our data included 242 patients with BC.

THE FAMILIAL HYPOCALCIURIC HYPERCALCEMIA PRESENTED WITH ADVANCED HYPERCALCEMIA AND EXTREMELY HIGH PARATHORMON LEVELS (CASE REPORT).

Familial Hypocalciuric Hypercalcemia (FHH) is a rare benign condition inherited in an autosomal dominant pattern with high penetrance. This rare genetic condition is detected in approximately 2% of cases examined as primary hyperparathyroidism (PH). The Calcium Sensing Receptor (CaSR) gene's inactivating mutations result in a calcium-parathormone level-saturation curve shift to the right.

Supercritical carbon dioxide application using hydantoin acrylamide for biocidal functionalization of polyester.

Biocidal functionalization in polyester fibers is a really tough challenge because of the lack of tethering groups. This study indicated supercritical carbon dioxide application using -halamine would be an alternative solution for obtaining antibacterial function on the polyester surface. Firstly, -(2-methyl-1-(4-methyl-2,5-dioxo-imidazolidin-4 yl)propan-2 yl)acrylamide was synthesized and applied to the polyester in supercritical carbon dioxide medium, at 120 °C, 30 MPa for different processing times.

Unveiling the optical parameters of vanadium dioxide in the phase transition region: a hybrid modeling approach.

The phase change behavior of vanadium dioxide (VO) has been widely explored in a variety of optical and photonic applications. Commonly, its optical parameters have been studied in two extreme regimes: hot (metallic) and cold (insulating) states. However, in the transition temperatures, VO acts like an inherent metamaterial with mixed metallic-insulating character.

Dynamic beam splitter employing an all-dielectric metasurface based on an elastic substrate.

Beam splitters are an indispensable part of optical measurements and applications. We propose a dynamic beam splitter incorporating all-dielectric metasurface in an elastic substrate under external mechanical stimulus of stretching. The optical behavior at 720 nm wavelength shows that it can be changed from a pure optical-diode-like behavior to a dynamic beam splitter.

Automatic phase reversal detection in routine EEG.

Electroencephalograph (EEG), a valuable tool in the clinical evaluation, is readily available, safe and provides information about brain function. EEG interpretation is important for the diagnosis of neurological disorders. The long-term EEG data may be required to document and study neurosciences that include many epileptic activities and phase reversal (PR) etc.

Polarization-insensitive beam splitters using all-dielectric phase gradient metasurfaces at visible wavelengths.

Beam splitters play important roles in several optical applications, such as interferometers, spectroscopy, and optical communications. In this study, we propose and numerically examine polarization-insensitive beam splitters utilizing two-step phase gradient all-dielectric metasurfaces in the visible spectrum. The metasurface is made of periodically arranged binary unit cells, and phase difference between neighboring unit cells on the surface is 180 deg.

Comparison of two procedures for symptomatic hemorrhoidal disease: Ligation under Vision and Ferguson Hemorrhoidectomy - a retrospective cohort study.

Objective: To compare Ligation under Vision (LUV) with Ferguson Hemorrhoidectomy (FH) in patients with Grade II, III and IV hemorrhoidal diseases according to their postoperative outcomes.

Methods: Between July 2008 and August 2014, 155 patients underwent FH and 120 patients LUV, in Sakarya University Teaching and Research Hospital. Our retrospective analysis focuses on postoperative complications, postoperative pain and rate of recurrence.

Measuring the Effect of Filters on Segmentation of Developmental Dysplasia of the Hip.

Background: Developmental dysplasia of the hip (DDH) can be detected with ultrasonography (USG) images. However, the accuracy of this method is dependent on the skill of the radiologist. Radiologists measure the hip joint angles without computer-based diagnostic systems.

Pancreatic schwannoma: A rare case and a brief literature review.

Introduction: Pancreatic schwannoma (PS) is an extremly rare benign tumor. Less than 50 cases of pancreatic schwannoma have been described in the English literature over the past thirty years.

Presentation Of Case Report: A 63-year-old female underwent left modified radical mastectomy 2 years ago due to breast cancer.

Omnidirectional, broadband light absorption using large-area, ultrathin lossy metallic film coatings.

Resonant absorbers based on nanostructured materials are promising for variety of applications including optical filters, thermophotovoltaics, thermal emitters, and hot-electron collection. One of the significant challenges for such micro/nanoscale featured medium or surface, however, is costly lithographic processes for structural patterning which restricted from industrial production of complex designs. Here, we demonstrate lithography-free, broadband, polarization-independent optical absorbers based on a three-layer ultrathin film composed of subwavelength chromium (Cr) and oxide film coatings.

Intensity tunable infrared broadband absorbers based on VO2 phase transition using planar layered thin films.

Plasmonic and metamaterial based nano/micro-structured materials enable spectrally selective resonant absorption, where the resonant bandwidth and absorption intensity can be engineered by controlling the size and geometry of nanostructures. Here, we demonstrate a simple, lithography-free approach for obtaining a resonant and dynamically tunable broadband absorber based on vanadium dioxide (VO2) phase transition. Using planar layered thin film structures, where top layer is chosen to be an ultrathin (20 nm) VO2 film, we demonstrate broadband IR light absorption tuning (from ~90% to ~30% in measured absorption) over the entire mid-wavelength infrared spectrum.

Reduced near-infrared absorption using ultra-thin lossy metals in Fabry-Perot cavities.

We show that a triple-layer metal-insulator-metal (MIM) structure has spectrally selective IR absorption, while an ultra-thin metal film has non-selective absorption in the near infrared wavelengths. Both sub-wavelength scale structures were implemented with an ultra-thin 6 nm Cr top layer. MIM structure was demonstrated to have near perfect absorption at λ = 1.