Publications by authors named "Koc K"

Intramedullary schwannomas are a type of benign spinal cord tumor that originates from the Schwann cells of the nerve sheath. They are relatively rare and typically occur within the spinal cord itself, rather than in the surrounding tissue. Treatment options for cervical intramedullary schwannomas include surgical removal of the tumor, radiation therapy, and observation.

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Background: The purpose of this study was to examine the reliability and validity of the Turkish version of the Nursing Activities Score.

Methods: To validate the Turkish version of the Nursing Activities Score, a sample comprising 30 adult intensive care patients and 30 nurses was employed. After a pilot study, the internal consistency, Cronbach's alpha coefficient, was found to be p = 0.

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Article Synopsis
  • The study focuses on creating an injectable subdermal implant material made of calcium hydroxyapatite (CaHA) and a carrier mix of carboxymethyl cellulose (CMC), glycerol, and water, aimed at enhancing soft tissue repair.
  • Various analytical methods, including X-ray diffraction (XRD) and scanning electron microscopy (SEM), confirmed the material's structural integrity, particle size, and thermal stability, demonstrating that the CaHA particles were evenly distributed.
  • In animal testing, the CaHA/CMC gel showed promise by significantly improving skin thickness and collagen density compared to a similar product, indicating its potential as a biocompatible and biodegradable option for soft tissue applications.
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The last glacial period is characterized by abrupt climate oscillations, also known as Dansgaard-Oeschger (D-O) cycles. However, D-O cycles remain poorly documented in climate proxy records covering the penultimate glacial period. Here we present highly resolved and precisely dated speleothem time series from Sofular Cave in northern Türkiye to provide clear evidence for D-O cycles during Marine Isotope Stage (MIS) 6 as well as MIS 2-4.

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Background: Open inguinal hernia repair (OIHR) surgery is a common surgical procedure, and ultrasound guided interfascial plane blocks can also be included in current approaches to postoperative multimodal analgesia regimens. This study aimed to compare the postoperative analgesic efficacy of the erector spinae plane block (ESPB) and transversalis fascia plane block (TFPB) in patients undergoing OIHR.

Methods: This prospective, randomized, assessor-blinded comparative study was conducted in the postoperative recovery room and ward of a tertiary hospital.

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exhibit a wide variety of medicinal and pharmacological effects. The present study aims to determine the role of ethanol extract of on oleic acid (OA)-induced acute respiratory distress syndrome (ARDS) in rats. Male rats were randomly divided into the following groups: (I) Control, (II) OA, and (III) OA+ extract (500 mg/kg) was given orally for 2 weeks before OA in Group III.

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  • The adrenal gland in humans makes important hormones and has different areas that do different jobs.
  • Scientists studied human adrenal glands to see how cells change and develop, especially to learn more about adrenal diseases like primary aldosteronism.
  • They found that cells in the adrenal gland develop in a specific way from the outside to the inside and discovered differences in tiny hormone-producing areas in older people, which helps us understand how the adrenal gland works normally and when it’s not healthy.
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Background: Total Knee Arthroplasty (TKA) is one of the most commonly performed orthopedic procedures, and patients complain of severe pain in the postoperative period. The supra-inguinal fascia iliaca block (SIFIB) works as an anteriorly applied lumbar plexus block and is frequently used in hip surgeries. In this study, we evaluated the effect of SIFIB in patients undergoing TKA under spinal anesthesia.

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In recent years there has been a great deal of research into environmental pollution using a variety of techniques in response to growing environmental concerns. Convergence analysis, one of these techniques, helps determine whether the developing countries will catch up with the rich countries in pollution using unit root tests. However, the vast majority of the research in the field has generally used conventional unit root tests.

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The aim of this study is to examine the perceptions and experiences of older people regarding health promotion. Using a phenomenological design, semi-structured in-depth interviews were conducted with 22 older people. Data analysis was carried out according to the Colaizzi's method.

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This study investigates the protective role of Hispidulin on acute respiratory distress syndrome (ARDS) in rats. Rats were divided into three groups: control, ARDS, ARDS+ Hispidulin. The ARDS models were established by injecting rats with oleic acid.

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Purpose: This study aimed to determine posttraumatic growth and psychological resilience and understand the relationship between posttraumatic growth and psychological resilience in frontline nurses.

Methods: This study was conducted on 263 nurses working at the pandemic clinics of a hospital of a healthcare group in Istanbul and a public hospital in Bursa between June 20 and September 01, 2020. Data were collected online to avoid the risk of infection using the personal information form, the Connor-Davidson resilience scale and the posttraumatic growth inventory.

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Two new 1,2,4-triazine-containing sulfonamide derivatives, namely, 4-bromo-N-(5,6-diphenyl-2H-1,2,4-triazin-3-ylidene)benzenesulfonamide, CHBrNOS, 3a, and methyl 2-{[(5,6-diphenyl-1,2,4-triazin-3-yl)sulfamoyl]methyl}benzoate, CHNOS, 3b, which crystallize in the different sulfonimide and sulfonamide tautomeric forms, respectively, were synthesized and characterized by spectroscopic, X-ray diffraction and theoretical calculation methods. Both molecules adopt a very similar conformation of the common part of the structure and the differences occur within the substituents on the sulfonamide group. The amino groups characteristic for the existing tautomeric forms are involved in strong intermolecular N-H.

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We investigated the role of boric acid (BA) in ovarian tissue damage caused by ischemia/reperfusion (I/R) in the rat. We established four groups of seven adult female rats: untreated control; ovarian I/R; 15 mg/kg BA; I/R + 15 mg/kg BA. Ovarian levels of lipid peroxidase (LPO), myeloperoxidase (MPO), glutathione (GSH), catalase (CAT), superoxide dismutase (SOD) and interleukin-6 (IL-6) were measured biochemically.

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Acute kidney damage is defined as a sudden change in kidney functions that prevents the removal of nitrogenous wastes from the body, thus disrupting the body's fluid and electrolyte balance. When acute kidney injury occurs, the kidneys and liver are most affected in the body. Agents used in the treatment of acute kidney injury often have nonsteroidal anti-inflammatory properties that can produce toxic effects on the gastrointestinal tract and kidneys.

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Chia seeds () are obtained from L. This raw material is distinguished by its rich chemical composition and valuable nutritional properties. It is currently referred to as "health food".

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In the present study, steady numerical simulations performed on the counter rotating turbo fan (CRTF) COBRA are compared with experimental data carried at the CIAM C-3A test-bench in Moscow. For this purpose, a systematic analysis of the measurement uncertainties was performed for the global aerodynamic performances of the CRTF, namely, the massflow, the total pressure ratio, the isentropic efficiency, as well as the torque ratio applied on both fan rows. Several numerical models are investigated to highlight their effects on the aforementioned predicted quantities.

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Objective: Crude oil extracts, components of extracts, and ethanolic extracts of Inula graveolens possess various pharmacological activities on various cancer cells including antioxidative and antiproliferative effects. Aqueous extract of this species has not been investigated on the liquid malignancies and solid tumors with a high incidence of treatment refractoriness and poor survival outcomes such as glioblastoma and leukemia. Hence, the present study aimed to evaluate the cytotoxic efficiency of I.

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Adrenoleukodystrophy is a rare X-linked hereditary disease that results in accumulation of very-long-chain fatty acids in all body tissues, thus causing demyelination of the white matter. Magnetic resonance imaging (MRI) is a reliable radiological modality to demonstrate the extension of brain lesions and severity of the disease. In the classic form, the parieto-occipital white matter is affected.

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Article Synopsis
  • Recent studies have improved our understanding of the genetic pathways in adrenocortical carcinoma (ACC), a cancer with low survival rates, emphasizing the need to find targetable genomic changes to enhance patient outcomes.
  • Analysis of 364 patient ACC samples revealed common genetic alterations, particularly in epigenetic pathways, tumor suppressor genes, and the WNT signaling pathway, with a significant portion also showing defects in the DNA mismatch repair (MMR) pathway.
  • More than half of the analyzed tumors displayed at least one actionable genomic alteration, suggesting that targeted sequencing could provide valuable insights for treatment, while the prevalence of MMR gene mutations indicates potential for immunotherapy options.
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The steady increase in the employment of silver nanoparticles (AgNPs) in consumer products entails the determination of the aquatic toxicity of AgNPs. Various AgNP characteristics including particle size, and shape, surface charge, and material have prominent effects on ecotoxicity. In the present study, we investigated the aquatic toxicity of chemically-synthesized AgNPs (Che-AgNPs) and green synthesis AgNPs (Gr-AgNPs) to as a model organism.

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β-blockers having specific affinities to β-adrenergic receptors are routinely used to treat cardiovascular problems. Additionally, it has been demonstrated that these drugs can be effective in treating apoptosis-related diseases. The current study was conducted to investigate the cytotoxic and apoptotic effects of β-1 selective esmolol, β-2 selective ICI-118,551, and non-selective nadolol blockers on the cancerous and healthy lung cells.

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The impacts of urbanization on water quality, hydrology, society, and the environment can be minimized through low impact development (LID) practices in urban areas. This study has evaluated the performances of seven different LID scenarios including stand-alone and different combinations of green roof (GR), bioretention cells (BC), permeable pavement (PP), and infiltration trench (IT) in the Ayamama watershed, which is one of the most densely urbanized areas in Istanbul. Stormwater Management Model (SWMM) was used to obtain the performances of LID scenarios in quantitative (i.

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Metastatic disease in pheochromocytomas and paragangliomas (PCC/PGL) is not well-understood. The Cancer Genome Atlas discovered recurrent fusion genes in a subset of tumors that lacked known germline or somatic driver mutations and were associated with aggressive disease. Here, we aimed to investigate the role of MAML3 in tumorigenesis.

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In holometabolous insects, many tissues and organs such as the fat body and midgut undergo a remodeling process during metamorphosis. Larval fat body cells are eliminated by programmed cell death (PCD), while tissue cells that adapt to adult life are formed by stem cells. In this study, we analyzed the features of the remodeling period of Galleria mellonella fat body in terms of PCD types, apoptotic and autophagic cell death characteristics.

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