Pentoxifylline potentiates antiepileptic activity of diazepam on the model of treatment-resistant focal epilepsy.

Kindling-syndrome was modeled in male Wistar rats using repeated corazole administration (25-30 mg/kg intraperitoneally). The effects of pentoxifylline (25 and 100 mg/kg intraperitoneally) and diazepam (0.05 and 1 mg/kg intraperitoneally) were studied in 3 weeks after kindling development under conditions of acute observation on the model of penicillin-induced foci in cerebral cortex.

Specificity of action of epileptogenic agents in diazepam-tolerant rats.

The development of tolerance in rats by repeated intraperitoneal injection of 0.5 mg/kg diazepam increased the sensitivity of the frontal cortex to the epileptogenic effect of NMDA and kainic acid. The median effective dose of NMDA was shown to decrease under these conditions.

[Activation of cerebral antioxidant mechanisms in electric stimulation of the paleocerebellar cortex].

Electrical stimulations (ES, 100 Hz) of the paleocerebellar cortex (Iuvula and flocculus) were performed in male Wistar rats. Similar stimulations of the frontal cortical zones were used as control. Lipid peroxidation intensity was estimated spectrophotometrically by the level of products reacting with thiobarbituric acid.

Effects interferon-2alpha on seizures in corasol-induced kindling.

Intracerebroventricular injection of recombinant human interferon-2alpha (100-500 U/rat) decreased the mean effective dose of corasol inducing clonic convulsions in 50% kindled Wistar rats. This effect was more pronounced in delayed periods of kindling and was accompanied by enhancement of epileptiform signs on EEG.

[The influence of electrical stimulation of the paleocerebellar cortex upon spike-wave activity induced at the early stage of corazol-induced kindling in rats].

Chronic Wistar rats experiments have shown that repeated administrations of corazol in subthreshold dosages (30.0 mg/kg, i.p.

Influence of transcranial magnetic stimulation on spike-wave discharges in a genetic model of absence epilepsy.

Transcranial magnetic stimulation (TMS) impulses, (0.5 Hz, 3 impulses) were presented at threshold intensity to male WAG/Rij rats. One group received stimuli, which involved motor responses of hindlimbs, rats of the second group received sham stimulation.

Are there different mechanisms of synchronization in the course of spike-wave discharges (SWDs) burst development in WAG/Rij rats?

In WAG/Rij rats the pair linear correlation r was calculated for bipolar recordings in fronto-temporal, fronto-occipital and occipito-temporal zones of both hemispheres as well as in paleocerebellar cortex (culmen). It was shown that development of SWD bursts resulted in interhemispheric decreases of correlation between the right occipito-temporal cortical region on one side, and left fronto-temporal on the contralateral side. Towards the end of SWD, we found an increased interhemispheric correlation between left fronto-temporal and right fronto-occipital cortical zones, as well as, between both fronto-temporal zones.

The effects of L-DOPA and transcranial magnetic stimulation on behavioral reactions in kindled rats.

Acute experiments were performed on rats to produce a model of chronic epileptic activity--pharmacological kindling by repeated doses of picrotoxin (1.0-1.2 mg/kg, i.

[Effects of L-dopa and transcranial magnetic stimulation on behavioral reactions in kindled rats].

In acute experiment in rats, the chronic epileptogenesis was reproduced in the form of pharmacological kindling induced via repeated picrotoxin administrations (1.0-1.2 mg/kg, intraperitoneally).