In silico prediction, characterization, docking studies and molecular dynamics simulation of human p97 in complex with p37 cofactor.

Background: The AAA + ATPase p97 is an essential unfoldase/segragase involved in a multitude of cellular processes. It functions as a molecular machine critical for protein homeostasis, homotypic membrane fusion events and organelle biogenesis during mitosis in which it acts in concert with cofactors p47 and p37. Cofactors assist p97 in extracting and unfolding protein substrates through ATP hydrolysis.

The AAA+ ATPase p97 as a novel parasite and tuberculosis drug target.

The multifunctional AAA+ ATPase p97 is an unfoldase/segregase involved in various cellular processes and present in all kingdoms of life. In mammals and yeast, p97 functions upstream of the proteasome. Interestingly, proteasome inhibitors targeting pathogenic microorganisms display efficacy in overcoming drug-resistant strains.

[Influence of antioxidant therapy on teeth firm tissues after endobleaching].

By endobleaching in the issue of peroxide penetration, extensively decreases adhesion of teeth tissues in dentinal canaliculus that in turn, demands to delay for some days the procedure of restoration by a filling. And it is inconvenient enough for patients. Proceeding from carried out researches, it is possible to consider the best way out an antioxidants usage after bleaching.

[Benefits of antioxidant agents' use for dental filling consequent to the endo-bleaching].

Efficacy of antioxidant agents' use after dental endo bleaching was studied in clinical trial. The study enrolled 169 patients, ranging age 16 to 60 years in age. The patients were randomized into 2 groups: control (63) and trial (106).

[Correlation of bleached teeth's tissue micro-durability and time of placing the dental filling].

Bleaching of discolored teeth has become one of the pressing issues of modern aesthetic dentistry in Georgia. Correct selection of endo-bleaching substances is crucial in resolving this issue, as it is well known that endo-bleaching agents penetrate into the dental tissues, causing "microcracks". Aim of our study became selection of right materials for dental bleaching, as well as finding additional methods of prevention these materials from penetrating into the dental tissue.

[Study of influence of endoopalescence on the solid tissue by means of raster microscope].

During the process of endowhitening as a result of penetration of peroxide into dentine tubules the adhesion of tooth tissues sharply decreases, it requires the delay of restoration by filling for several days. Surely it is not comfortable for the patient. The best way out is the application of antioxidants after whitening.

[Influence of whitening endoopalescence systems on the restoration of devitalized teeth].

At the end 80s of the XX century bleaching of teeth became one of the most important issues in the stomatological industry. Currently there are two methods of bleaching: external and internal (endo bleaching) methods. It is proved that the adhesive ability of the tooth tissues reduces as a result of peroxide penetration into enamel and dentine.

[Connectin from muscle cells is a collagen protein].

By X-ray analysis a collagen-like structure was observed in the muscle protein connectin . Hydration of species gives a clearer diffraction pattern, which is characteristic of the collagen-like structures. The functional role of connectin should consist in the fixation of maximum length of muscular cells.