Publications by authors named "Ko-Ping Chang"
Extracellular vesicles (EVs) are an important regulatory factor for natural killer cell activity (NKA) in the tumor microenvironment. The relationship between circulating EVs in the peripheral blood and natural killer (NK) cells in prostate cancer (PCa) is unclear. This study aimed at investigating the key regulators in the interaction between circulating EVs and NK cells in PCa patients before and after tumor removal.
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- * Researchers used proteomics to identify CARMIL3 as a key protein that is significantly increased in the T2(+) and mismatch areas of the brain, mainly found in neurons, and linked to various cellular stress markers such as edema and oxidative stress.
- * The findings suggest that the presence of CARMIL3 can serve as a molecular indicator of brain ischemia, highlighting its role in the pathological processes occurring shortly after a stroke.
Myeloproliferative neoplasms (MPNs) are characterized by upregulation of proinflammatory cytokines and immune dysregulation, which provide a reasonable basis for immunotherapy in patients. Megakaryocytes are crucial in the pathogenesis of primary myelofibrosis (PMF), the most clinically aggressive subtype of MPN. In this study, we aimed to explore PD-L1 (programmed death-ligand 1) expression in megakaryocytes and its clinical implications in PMF.
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