Publications by authors named "Ko-Chia Chen"

Article Synopsis
  • Cervical spinal injuries disrupt blood pressure control, leading to potential cardiovascular issues, and while current guidelines recommend maintaining blood pressure with vasopressors, it may worsen spinal hemorrhage and injury.* -
  • This study investigates whether the use of the vasopressor phenylephrine increases spinal hemorrhage and extravasation compared to saline in animal models, and assesses the impact of spinal decompression surgery.* -
  • Results show that phenylephrine elevates blood pressure but worsens spinal damage, while spinal decompression surgery reduces the extent of hemorrhage and extravasation in treated animals.*
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This study explored the relationship and influence of college students' participation in water leisure sports, as well as the technology acceptance model (TAM). With the rapid development of the economy, the government is promoting various water leisure sports centered on the concept and policy of a maritime- and ocean-based nation. Based on the TAM, this study investigated the relationships among its ease of use, usefulness, water leisure involvement, benefits, barriers, and intentions to participate in water activities in connection with college students participating in water leisure sports.

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Limited research has evaluated the performance of physical education (PE) teachers. This study aimed to use person-environment fit and organizational support to evaluate PE teachers' work performance using multilevel analysis. The relationship between person-environment fit and performance of university physical education teachers (at the person-level) and a cross-level effect on performance of university physical education teachers of perceived organizational support (at the school-level) and a moderator effect of organizational support were examined.

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Aim: The relationship between declining performance, as measured by changes in reaction time, and declining cognitive function has not been critically studied. The aim of the present study was to investigate the association between reaction time during a task and cognitive ability in elderly Taiwanese individuals.

Methods: Patients aged 65 years or older with mild cognitive impairment (MCI) (n = 33) and Alzheimer's disease (n = 26) were recruited from the neurology clinic of a regional hospital in southern Taiwan.

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According to an investigation done by Taiwan Ministry of the Interior in 2013, there was more than 90% of the disability care institutions mainly based on life care. Previous studies have shown that individuals can effectively improve physical and cognitive training, improved in independent living and everyday competence. The purpose of the study was to investigate influence of the intervention program applying functional fitness and cognitive training to disabled residents in the institution.

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Quercetin, a flavonoid abundantly present in plants, is widely used as a phytotherapy in prostatitis and prostate cancer. Although quercetin has been reported to have a number of therapeutic effects, the cellular target(s) responsible for its anti-cancer action has not yet been clearly elucidated. Here, employing affinity chromatography and mass spectrometry, we identified heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) as a direct target of quercetin.

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Article Synopsis
  • * Among nearly 500 chemical compounds tested, MT4 was found to significantly reduce the release of TNF-alpha and IL-1beta, demonstrating effective anti-inflammatory properties with IC50 values of 22 nM and 44 nM, respectively.
  • * The mechanism of MT4's action involves the inhibition of p38alpha and p38beta MAPK activity, with competitive binding to the ATP substrate site, indicating a potential target for treating chronic inflammation.
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