Publications by authors named "Ko Matsuo"
[Behavioral variant of frontotemporal dementia with stereotypic speech: a case report].
Rinsho Shinkeigaku
December 2024
Article Synopsis
- An 85-year-old man with behavioral variant frontotemporal dementia displayed reduced spontaneous speech and stereotypic speech patterns, indicating a progressive language disorder over two years, accompanied by changes in eating behavior.
- MRI scans revealed atrophy in the left frontal lobe, particularly affecting the superior, middle, and inferior frontal gyrus, while brain imaging showed decreased blood flow in these regions and the left basal ganglia.
- The diagnosis of behavioral variant frontotemporal dementia was reached due to the patient's specific symptoms, the observed progression, and evidence of brain lesions, with the stereotypic speech deemed as non-meaningful recurrent utterances.
Antibody against myelin oligodendrocyte glycoprotein (MOG-IgG) associated encephalitis is an important syndrome associated with MOG-IgG. However, there have been no reports of MOG-IgG-associated optic neuritis or demyelination following meningitis without encephalitic symptoms. A 55-year-old woman presented to our hospital with headache, nausea, fever, and nuchal rigidity that had persisted for more than a month.
View Article and Find Full Text PDFThe pathogenesis of cortical microinfarcts (CMIs) is considered to be heterogeneous including cerebral small vessel disease (SVD) such as hypertensive vasculopathy (HV) and cerebral amyloid angiopathy (CAA). Recent advances in MRI have enabled the detection of CMIs in vivo. To investigate the characteristics of CMIs in advanced cerebral SVD, we performed a retrospective analysis of 85 patients with cognitive impairment who had multiple lobar cerebral microbleeds (CMBs) on 3 T MRI.
View Article and Find Full Text PDFSubregional heterogeneity of somatosensory dysfunction in the insula.
J Neurol Neurosurg Psychiatry
August 2019
Complement Activation in Capillary Cerebral Amyloid Angiopathy.
Dement Geriatr Cogn Disord
September 2018
Background: Cerebral amyloid angiopathy (CAA) is classified as type 1 with capillary amyloid β (Aβ) or type 2 without capillary Aβ. While it is known that CAA activates complement, an inflammatory mediator, there is no information on the relationship between capillary Aβ and complement activation.
Methods: We evaluated 34 autopsy brains, including 22 with CAA and 12 with other neurodegenerative diseases.
Article Synopsis
- Microvascular lesions such as cortical microinfarctions (CMIs) and cerebral lobar microbleeds (CMBs) are often linked to cerebral amyloid angiopathy (CAA) in older adults and are associated with cognitive decline.
- This study used 3T MRI and histological analyses to explore the relationship between these microvascular lesions and CAA, examining brain samples from both CAA patients and those with other neurodegenerative diseases.
- Findings showed a significant presence of CMIs and CMBs near amyloid-positive blood vessels in CAA patients, suggesting that CAA plays a key role in the development of these lesions, with MRI effectively detecting certain lesions, particularly larger ones.
Over 100 mutations have been described in the presenilin-1 gene (PSEN1), resulting in familial Alzheimer disease (AD). However, of the limited number of autopsy cases, only one has been reported from an AD family with an L420R PSEN1 mutation. We describe here clinical and neuropathological features of a patient with dementia-parkinsonism from a family with a PSEN1 mutation (L420R).
View Article and Find Full Text PDFArticle Synopsis
- The study investigates cortical microinfarcts (CMIs) in autopsy brains, which are small brain lesions linked to cerebral amyloid angiopathy (CAA) and potential dementia risk, utilizing advanced MRI techniques (DIR and 3D-FLAIR) that can visualize these previously undetectable CMIs.
- Researchers examined 70 subjects with various forms of dementia, using susceptibility-weighted imaging (SWI) to identify cerebral microbleeds (CMBs) alongside the DIR and 3D-FLAIR imaging.
- Results showed that nine subjects had small lesions consistent with CMIs, located near CMBs, indicating that DIR and 3D-FLAIR imaging can effectively