Single-cell transcriptomics reveals prominent expression of IL-14, IL-18, and IL-32 in psoriasis.

Rationale: Psoriasis is a chronic inflammatory skin disease involving different cytokines and chemokines.

Objectives: Here we use single-cell transcriptomic analyses to identify relevant immune cell and nonimmune cell populations for an in-depth characterization of cell types and inflammatory mediators in this disease.

Methods: Psoriasis skin lesions of eight patients are analyzed using single-cell technology.