Canine vascular neoplasia--a population-based clinicopathologic study of 439 tumours and tumour-like lesions in 420 dogs.

This paper deals with a population-based material collected during the years 1990-1998, and comprises 439 tumours and tumour-like vascular processes from 420 dogs. Anatomic location, age, breed and gender are reported. A distinction is made between benign neoplasms, tumours of intermediate malignancy, and obvious malignant processes (angiosarcomas).

Canine vascular neoplasia--histologic classification and inmunohistochemical analysis of 221 tumours and tumour-like lesions.

A light microscopic evaluation of 221 canine vascular tumours and tumour-like lesions, supplemented by immunohistochemistry (von Willebrand Factor, CD31, vimentin), revealed a high degree of conformity with similar conditions in humans. Four main categories of tumours are reported, i.e.

Canine neoplasia--introductory paper.

The paper gives a brief introduction to canine oncology, including its comparative aspects as basis for recording tumours in the animal kingdom. In an abbreviated presentation of the Norwegian Canine Cancer Project for the years 1990-1998, the data (n=14,401) were divided into age groups, each of two years, into different categories of tumours, and into age and gender. As expected, cutaneous histiocytoma was the dominant tumour type in both sexes during the two first years of life.

Serum amyloid A protein forms a complex with a fragment of apolipoprotein A-I in the domestic blue fox: a protective mechanism against AA amyloidosis?

The spontaneous occurrence of protein AA-type of amyloidosis varies among animal species. As reactive AA-type of amyloidosis has never been detected in the blue fox, we obtained acute phase sera to search for amyloid-protective elements. The purified SAA fraction was characterized by mass and sequence analyses to disclose any unique domains in the amino acid sequence.

Lipoprotein lipase in the kidney: activity varies widely among animal species.

Much evidence points to a relationship among kidney disease, lipoprotein metabolism, and the enzyme lipoprotein lipase (LPL), but there is little information on LPL in the kidney. The range of LPL activity in the kidney in five species differed by >500-fold. The highest activity was in mink, followed by mice, Chinese hamsters, and rats, whereas the activity was low in guinea pigs.

Splenic ellipsoids: an early target for deposition of AA amyloid induced in mink.

The spleen is the primary target for spontaneous as well as experimental AA amyloidosis in animals such as mice and mink, and is therefore a valuable organ for study of the initial phases of amyloid fibrillogenesis and deposition. We have investigated splenic amyloid AA deposits induced in the mink, and we demonstrate a novel target for AA, namely the splenic ellipsoids. We show presence of amyloid P component (AP), glycosaminoglycans (GAGs) and apolipoprotein E (apoE), all well-known common elements of amyloid, co-localizing with AA.