Porphyrins developed for photoinactivation of microbes in wastewater.

Photodynamic antimicrobial chemotherapy (PACT) is extensively studied as a strategic method to inactivate pathogenic microbes in wastewater for addressing the limitations associated with chlorination, ozonation, and ultraviolet irradiation as disinfection methods, which generally promote the development of resistant genes and harmful by-products such as trihalomethanes. PACT is dependent on photons, oxygen, and a photosensitizer to induce cytotoxic effects on various microbes by generating reactive oxygen species. Photosensitizers such as porphyrins have demonstrated significant microbial inactivation through PACT, hence now explored for wastewater phototreatment.

Photophysical and in vitro photoinactivation of Escherichia coli using cationic 5,10,15,20-tetra(pyridin-3-yl) porphyrin and Zn(II) derivative conjugated to graphene quantum dots.

Pathogenic microorganisms may continue causing infection through the transfer of antibiotic resistance genes. As a result, the efficacy of pharmaceuticals in microbial inactivation is deteriorating. The present study was conducted to investigate the antimicrobial activity of neutral and quaternized free base and Zn 5,10,15,20-tetra(pyridin-3-yl) porphyrins on Escherichia coli (E.