[The comparison of laboratory tests Quantiferon, Tubinferon and Diaskintest in children with tuberculosis infection.].

The study was carried out to compare results of three tests on the basis of antigens CFP-10 and ESAT-6: laboratory tests QuantiFERON (QFT) and Tubinferon (TIF) and intra-cutaneous test with allergen tuberculous recombinant - Diaskintest (DST). Tubinferon is a Russian analog of test QuantiFERON and is based on quantitative analysis of interferon-gamma after incubation of samples of whole blood in the presence of antigens of Mycobacterium tuberculosis (MBT) - tuberculin and recombinant antigens ESAT-6 and САЗ-10. The results QFT, TIF and DST are examined on 63 patients aged from 7 months to 15 years at parallel setup.

[Use of polymerase chain reaction in the diagnosis of tuberculosis in children with diseases of the bronchopulmonary system].

A comprehensive study was conducted to determine the activity of tuberculous infection in 115 patients who formed 3 groups: 1) patients with primary forms of tuberculosis; 2) those who were infected with Mycobacterium tuberculosis (MBT); and 3) those who were infected with bronchopulmonary diseases. The detection of MBT DNA in the blood by polymerase chain reaction (PCR) using a highly sensitive four-primed diagnostic kit established that 80 patients with tuberculosis had positive results and their decrease as the patient had a course of tuberculostatic therapy. The fact that a third of patients from Groups 2 and 3 had highly positive results of PCR required that a preventive course of double therapy be used for 3 to 6 months.

[Detection of Mycobacterium tuberculosis infection in children with bronchopulmonary diseases and evaluation of its role in the course of disease].

Of 190 children under 14 with nonspecific pulmonary diseases (NSPD) 32.4% had lingering pneumonia, 20.9% recurrent bronchitis.

[Characteristics of tuberculosis among children (data from a specialized hospital].

The results of analysis of 3076 case histories of patients who were studied in a specialized hospital of Leningrad in the period of 1984-1989 made it possible to give the present-day characteristic of tuberculosis infection in children aged up to 14 years. Study was conducted according to the accepted scheme and comprised analysis of a general composition of patients, clinical diagnosis structure, specific features of the different forms of tuberculosis, registration of complications, age, sex and territory factors and results of other investigations. Special emphasis was given to the characteristic of a group of children suffering from tuberculosis.