Induction of vascular endothelial growth factor-A in human retinal and endothelial cells in response to glyoxal.

Low-density lipoprotein (LDL) apheresis is effective and safe for patients with diabetes, proteinuria, and dyslipidemia. Diabetes mellitus is accompanied by ocular microvascular complications like retinal neovascularization or diabetic macular edema. These are leading causes of blindness and can be mediated by abnormal vessel growth and increased vascular permeability due to elevated levels of vascular endothelial growth factor (VEGF) in diabetic patients.

Efficacy of combining intravitreal injections of ranibizumab with micropulse diode laser versus intravitreal injections of ranibizumab alone in diabetic macular edema (ReCaLL): a single center, randomised, controlled, non-inferiority clinical trial.

Background: To evaluate if a combination therapy with micropulse diode laser (MPL) shows non-inferiority on visual acuity (BCVA) within 12 months in comparison to standard therapy, i.e. intravitreal injection of ranibizumab alone.

Reliability of Orbscan II topography measurements in relation to refractive status.

Purpose: To investigate the reliability of corneal topography measurements using the Orbscan II topography system (Bausch & Lomb) not only referring to a normal cohort but also to different refractive conditions.

Setting: Department of Ophthalmology, Ruprecht-Karls-University of Heidelberg, Heidelberg, Germany.

Methods: Eighty patients (mean age 46.

Performance of the 1CU accommodating intraocular lens in relation to capsulorhexis size.

Purpose: To assess the correlation between continuous curvilinear capsulorhexis (CCC) size and visual outcomes in patients with an accommodating intraocular lens (IOL).

Setting: Heidelberg IOL and Refractive Surgery Research Group, Department of Ophthalmology, Ruprecht-Karls-University of Heidelberg, Heidelberg, Germany.

Methods: Nineteen eyes had phacoemulsification and implantation of a 1CU accommodating IOL (HumanOptics AG).

Anterior chamber depth in relation to refractive status measured with the Orbscan II Topography System.

Purpose: To evaluate the anterior chamber depth (ACD) according to refractive status, assess the reliability of repeated ACD measurements using the Orbscan II Topography System (Bausch and Lomb), compare Orbscan II and IOLMaster (Carl Zeiss Meditec AG) ACD measurements, and investigate the correlation between refraction, axial length (AL), and ACD.

Setting: Department of Ophthalmology, Ruprecht-Karls-University of Heidelberg, Heidelberg, Germany.

Methods: In this clinical study, 60 patients with a mean age of 43.

Quantification of posterior capsule opacification with round and sharp edge intraocular lenses.

Purpose: To quantitatively evaluate and compare intraocular lenses (IOLs) with a round or sharp optic edge design for posterior capsule opacification (PCO).

Study Design: Prospective comparative observational case series. PARTICIPANTS/MATERIALS: Photographs from 174 eyes were analyzed for PCO at the Department of Ophthalmology, Ruprecht-Karls-University of Heidelberg, Heidelberg, Germany.