Obstetric and Neonatal Outcome of Pregnancy in Carney Complex: A Case Report.

Carney complex (CNC) is a rare multiple endocrine neoplasia syndrome with autosomal dominant inheritance. Affected individuals present with mucocutaneous lentigines/blue nevi, cardiac and noncardiac myxomatous tumors, and multiple endocrine tumors. Mutations in have been identified as genetic cause of the disease.

Effect of mono-(2-ethylhexyl) phthalate on steroid production of human granulosa cells.

The phthalate ester mono-(2-ethylhexyl) phthalate (MEHP) is the active metabolite of di-(2-ethylhexyl) phthalate, a high-production-volume chemical used as a plasticizer and solvent in numerous consumer products. MEHP has been demonstrated to be a reproductive toxicant in rodents decreasing estradiol and progesterone production in preovulatory granulosa cells. In the present study, we examined the effect of MEHP on steroid production of human granulosa-lutein (GL) cells.

pp'DDE contamination of the blood and diet in central European populations.

In this study, the actual risk of DDT pollution to two European human populations was assessed by analysing DDT residues in the diet, which is the main route of pollution for man, and in the blood and placenta, which are components affecting organs and new generations, respectively. The Gdańsk region was selected as representative of areas subjected to a recent DDT ban in Europe, while a rural area in Western Germany was considered representative of European regions where DDT use and production ceased many years ago. The results of three food series of food sampling carried out with market basket methods during 2003 showed that pp'DDE, which is by far the main constituent of DDT residues, was present in foods of animal origin and in cereals at rather high concentrations in both countries, and that a risk for human health cannot be excluded.

Interaction of renal prostaglandins with the renin-angiotensin and renal adrenergic nervous systems in healthy subjects during dietary changes in sodium intake.

In six healthy subjects the role of renal prostaglandins (PG) in modulating the actions of the renin-angiotensin and renal adrenergic nervous systems on renal function was investigated. During high dietary sodium intake (350 mmol/day) for 4 days no changes in urinary excretion of PGE2, PGF2 alpha, noradrenaline or adrenaline were noted, whereas plasma renin activity (PRA) and urinary aldosterone excretion were suppressed. After 4 days of low sodium intake (35 mmol/day) urinary excretion of PGE2, aldosterone and noradrenaline, as well as PRA, had significantly increased.