Levothyroxine in euthyroid autoimmune thyroiditis and type 1 diabetes: a randomized, controlled trial.

Context: Patients with type 1 diabetes (T1D) have an increased risk of autoimmune thyroiditis (AIT).

Objective: Our objective was to determine whether levothyroxine (l-T(4)) treatment prevents the clinical manifestation of AIT in euthyroid subjects with T1D.

Design And Setting: We conducted a prospective, randomized, open, controlled clinical trial at six tertiary care centers for pediatric endocrinology and diabetes.

Successful treatment of multiple Pseudallescheria boydii brain abscesses and ventriculitis/ependymitis in a 2-year-old child after a near-drowning episode.

Rationale: We report on a cerebral infection by Pseudallescheria boydii in a 21-month-old boy after a near-drowning episode. MRI revealed multiple (> 60) intracerebral abscesses.

Methods: The surgical therapy included CSF drainage and microsurgical resection of one abscess for microbiological diagnosis.

Increased serum soluble leptin receptor levels in children and adolescents with type 1 diabetes mellitus.

Objective: We investigated whether or not serum levels of the soluble leptin receptor (sOB-R) and leptin are related to anthropometric and metabolic changes during pubertal development of children and adolescents with type 1 diabetes mellitus.

Design And Methods: Blood levels of sOB-R, leptin and HbA1C, as well as body-mass index (BMI), diabetes duration and daily insulin doses, were determined in 212 (97 girls; 115 boys) children with type 1 diabetes mellitus and compared with the sOB-R serum levels in 526 healthy children and adolescents.

Results: OB-R serum levels and parallel values of the molar ratio between sOB-R and leptin were significantly higher in children with diabetes than in normal children (P<0.

Thyroid autoimmunity in children and adolescents with type 1 diabetes: a multicenter survey.

Objective: To investigate thyroid autoimmunity in a very large nationwide cohort of children and adolescents with type 1 diabetes.

Research Design And Methods: Data were analyzed from 17,749 patients with type 1 diabetes aged 0.1-20 years who were treated in 118 pediatric diabetes centers in Germany and Austria.

High frequency of diabetes-specific autoantibodies in parents of children with type 1 diabetes. DENIS study group.

Strategies to identify subjects at risk for type 1 diabetes are largely based on the detection of autoantibodies directed to various beta cell autoantigens. Most previous studies only comprise siblings and children of patients with type 1 diabetes; only scare data are available on the antibody profile in older relatives. In this study, we examined the prevalence of cytoplasmic islet cell antibodies (ICA), antibodies to glutamic acid decarboxylase (GADA), antibodies to the protein tyrosine phosphatase IA-2 (IA-2A) and IA-2beta (IA-2betaA) in 531 unaffected parents of patients with type 1 diabetes, and compared the results with antibody frequencies in 2425 siblings.

The Deutsche Nicotinamide Intervention Study: an attempt to prevent type 1 diabetes. DENIS Group.

On the basis of the positive outcome of animal experiments, several large placebo-controlled trials are underway and aiming for the first time at the prevention of an immune-mediated disease, type 1 diabetes. The first of these trials, The Deutsche Nicotinamide Intervention Study (DENIS), evaluated the clinical efficacy of high doses of nicotinamide in children at high risk for IDDM. Nicotinamide has been shown to protect beta-cells from inflammatory insults and to improve residual beta-cell function in patients after onset of IDDM.

[Correlation between glycemia control and lipid metabolism parameters in children with diabetes mellitus].

Screening for hypercholesterolaemia and hypertriglyceridaemia should be considered in children with diabetes mellitus. Studies on different serum lipids in children with Type I diabetes have shown different results. Hyperglycaemia is the primary abnormality of diabetes.

[Normalization of HBA1--a realistic therapeutic goal?].

Optimal regimen for therapy should lead to near-normal glycaemia in children with diabetes mellitus. Therefore normal or near-normal values of glycated haemoglobin (HbA1) during long periods seem to be very important for the assessment of the quality of metabolic control. However, reports published so far indicate that this goal for paediatric diabetology is currently not achieved in a considerable number of patients.