Publications by authors named "Klinger Marco"

Background: Prominent ears are a prevalent aesthetic concern, with numerous surgical techniques utilized in otoplasty procedures, without a widely approved gold standard. Traditional methods often leave residual deformities, reducing patient satisfaction.

Methods: We conducted a retrospective case series analysis involving 38 patients (30 Female, 8 Male) who underwent otoplasty to correct prominent ears for aesthetic purposes from January 2019 to December 2022.

View Article and Find Full Text PDF
Article Synopsis
  • Implant-based breast reconstruction is common after mastectomy, raising concerns about the safety of prostheses and their effect on breast cancer recurrence based on surface texture.* -
  • A study analyzed data from 646 patients who received either macrotexturized or microtexturized implants, with findings showing a cancer recurrence risk of 5.6% for macrotexturized and 2.1% for microtexturized implants.* -
  • Results indicated a significantly higher local recurrence risk (RR of 2.65) for those with macrotexturized implants, highlighting the need for further research on these outcomes.*
View Article and Find Full Text PDF

The introduction of PARP inhibitors has revolutionized the management and treatment of patients with pathogenic germline variants of BRCA1/2 who have developed breast cancer. The implementation of PARP inhibitors in clinical settings can be challenging due to their overlapping indications with other drugs, including both recently approved medications and those with proven efficacy. This study utilized the Delphi method to present the first Italian consensus regarding genetic testing, the use of PARP inhibitors in both early and metastatic settings, and strategies for managing the potential toxicity of these novel drugs.

View Article and Find Full Text PDF

Background: Breast augmentation in 2019 was the first among the top five cosmetic surgical procedures performed worldwide, according to the International Society of Aesthetic Plastic Surgery. It is not only the most commonly performed cosmetic surgery, but also the aesthetic procedure with the highest reoperation rate.

Methods: A retrospective observational study of 306 female patients who underwent secondary breast surgery, with a follow-up of at least 1 year after surgery, from 2010 to 2020 is presented.

View Article and Find Full Text PDF

Background: Postoperative seroma is most frequent after mastectomy (ME) in combination with axillary lymph node dissection (ALND), and its reported incidence varies from 15.5% up to 90%. Seromas can be responsible for discomfort, infections and can lead to reconstruction failure.

View Article and Find Full Text PDF
Article Synopsis
  • Value-based healthcare (VBHC) focuses on maximizing patient value and outcomes while minimizing costs, shifting the emphasis from the volume of services to the quality of care delivered.
  • This study evaluated the impact of a VBHC-principled preoperative evaluation at Humanitas Research Hospital by comparing results from 2019 (preintervention) to 2021 (postintervention).
  • The findings showed a significant reduction in preoperative tests and evaluation time, leading to lower healthcare costs without negatively affecting patient outcomes.
View Article and Find Full Text PDF
Article Synopsis
  • Conjunctival chemosis is a potential complication from lower blepharoplasty that can lead to discomfort and functional issues after surgery.
  • A study conducted at Humanitas Research Hospital analyzed 1047 patients who underwent two different surgical techniques for lower blepharoplasty: transconjunctival and transcutaneous, each with two methods of incision.
  • Results showed that the transcutaneous blepharoplasty with lateral canthoplasty had a significantly higher rate of persistent type 3 conjunctival chemosis compared to the transconjunctival technique, particularly when using radiofrequency methods.
View Article and Find Full Text PDF

Breast implants are extensively employed for both reconstructive and esthetic purposes. However, the safety of breast implants with textured surfaces has been questioned, owing to a potential correlation with anaplastic large-cell lymphoma and the recurrence of breast cancer. This study investigates the immune response elicited by different prosthetic surfaces, focusing on the comparison between macrotextured and microtextured breast implants.

View Article and Find Full Text PDF

Facelift surgery, also known as rhytidectomy, is a popular cosmetic procedure aimed at reversing the signs of facial aging. While facelift surgery is more commonly performed in women, an increasing number of men are seeking this procedure to maintain a youthful appearance. The long recovery period conflicts the overall primary outcome anticipated by men undergoing rhytidectomy, i.

View Article and Find Full Text PDF

• Despite the significance of oncoplastic procedure, an italian database is lacking. • Senonetwork established a multidisciplinary survey to assess their safety and efficacy. • Reconstructive outcomes were positive across low and high-volume centers.

View Article and Find Full Text PDF
Article Synopsis
  • Surgery, burns, and accidents often lead to scars that cause issues like pain and limited movement.
  • Autologous fat grafting can improve tissue quality, but it doesn’t always alleviate pain, prompting researchers to analyze cell types in fat tissue to find links to pain reduction.
  • A specific group of stem cells (CD3 - CD4 - CD304 +) in the grafted fat has been found to correlate strongly with pain relief after surgery, suggesting that enhancing these cells could boost the effectiveness of fat grafts in treating localized pain.
View Article and Find Full Text PDF

Background: Increasing adoption of implant-based breast reconstruction (IBR) has raised expectations regarding postoperative outcomes and aesthetic results. BMI has been extensively explored as a predictor of complications. This study is the first to examine complication rates in underweight subjects, and compares these rates among underweight, normal weight, overweight, and obese patients.

View Article and Find Full Text PDF

The employment of breast silicone implants, both in aesthetic and reconstructive medicine, is widespread thanks to their recognized biocompatibility and durability. Some critical situations, for example, in the case of accidental impacts, may induce concerns by potential patients about their use. Dynamic tests reproducing frontal impacts at speeds up to 90 km/h, with anthropomorphic dummies carrying 330 cc prostheses and wearing safety belts, were conducted.

View Article and Find Full Text PDF

Unlabelled: In the present study, we highlight surgical tips based on our experience in lower eyelid blepharoplasty. These have been shown to be crucial in the prevention of several complications, specifically lateral lower-lid displacement.

Methods: A series of bilateral lower-lid blepharoplasties were performed on 280 patients at Humanitas-Research-Hospital (Milan, Italy) between January 2016 and January 2020.

View Article and Find Full Text PDF
Article Synopsis
  • This review explores the therapeutic potential of human adipose tissue, highlighting its clinical applications and the role of mesenchymal stem cells derived from fat.
  • It addresses the enthusiasm from recent studies while also noting the criticism around the lack of rigorous scientific backing for some practices.
  • The research demonstrates that applying mechanical elliptical force to abdominal fat can enhance anti-inflammatory properties, suggesting new possibilities for clinical advancements.
View Article and Find Full Text PDF

Purpose: In modern breast cancer treatment, a growing role has been observed for breast reconstruction together with an increase in clinical indications for postmastectomy radiotherapy (PMRT). Choosing the optimum type of reconstructive technique is a clinical challenge. We therefore conducted a national multicenter study to analyze the impact of PMRT on breast reconstruction.

View Article and Find Full Text PDF

Flaps based on perforators of the intercostal arteries have been described for the reconstruction of defects resulting from partial mastectomies. Dynamic infrared thermography (DIRT) identifies hot spots that accurately correspond to and evaluate perforator vessels toward the skin. The new generation of portable thermal cameras has become smaller, less expensive, more sensitive, and compatible with common smartphones.

View Article and Find Full Text PDF

Antifibrinolytics, particularly tranexamic acid (TXA), are agents used to reduce bleeding. TXA is a synthetic reversible competitive inhibitor to the lysine receptor found on plasminogen. By reversibly binding to this site, it leads to plasminogen being unable to bind to fibrin and so prevents fibrinolysis, this stabilizes the clot and thus prevents hemorrhage.

View Article and Find Full Text PDF

Introduction: Tuberous breast deformity (TB) is a condition mostly characterized by breast stenosis, areolar widening and glandular asymmetry. The most accredited hypothesis describes an abnormal thickening of the fascia corporis that might influence an alteration in the glandular development, limiting the horizontal growth of breast parenchyma. Alterations in the extracellular matrix components (ECM) might be involved in the abnormal breast development.

View Article and Find Full Text PDF

Background: The increased incidence of conservative mastectomy operations (nipple- and skin- sparing) has increased the frequency of immediate breast reconstructions (IBR). In order to guarantee patients the best possible aesthetic outcome, the least chance of complications and moreover, the least postoperative pain, the technique with prepectoral prosthetic pocket was recently reconsidered with the use of ADM. This is the first study using Fortiva in prepectoral breast reconstruction, and it compares the outcomes of three different patient populations (undergoing retromuscular, prepectoral and prepectoral reconstruction with ADM).

View Article and Find Full Text PDF

Unlabelled: Tuberous breast (TB) deformity is a condition characterized by alterations in breast morphology and tissue structure with high prevalence in the general population. The literature provides sparse descriptions of TB, as not many investigations on the condition have been conducted. The aim of this review was to analyze and provide a holistic overview on the morphological characteristics of the TB.

View Article and Find Full Text PDF

Level of Evidence IV This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.

View Article and Find Full Text PDF