[Renal excretion of insulin-like growth factor 1 and vascular endothelial growth factor in patients with type 1 diabetes with nephropathy].

Thе aim of the investigation was to study the urinary excretion of insulin-like growth factor 1 (ICF-1) and vascular endothelial growth factor (VEGF) at different stages of nephropathy in 57 patients with type 1 diabetes, including 22 patients with normal albuminuria, 23 with microalbuminuria, and 12 with proteinuria. The excretion of IGF-1 and VEGF was increased in the microalbu-minuric and proteinuric patients as compared with the controls (1GF-1: p = 0.004 and p = 0.