[Comparative analysis of the results of treatment of patients with recurrent urethral stricture using platelet-rich plasma].

Introduction: The treatment tactics of patients with recurrent urethral stricture requires an integrated approach. An increase in the treatment efficiency is possible not only through improvements in surgical technique, but also by influencing the pathogenetic mechanisms of the formation of urethral stricture and stimulating regeneration.

Aim: To evaluate the efficiency of reconstructive procedures using platelet-rich plasma in patients with recurrent urethral stricture.

Ultra-Stretchable Microfluidic Devices for Optimizing Particle Manipulation in Viscoelastic Fluids.

Viscoelastic microfluidics leverages the unique properties of non-Newtonian fluids to manipulate and separate micro- or submicron particles. Channel geometry and dimension are crucial for device performance. Traditional rigid microfluidic devices require numerous iterations of fabrication and testing to optimize these parameters, which is time-consuming and costly.

Biocontrol Potential of the New Codling Moth Granulovirus (CpGV) Strains.

The use of CpGV strains as the basis for bioinsecticides is an effective and safe way to control . The research is aimed at the identification and study of new CpGV strains. Objects of identification and bioinformatic analysis: 18 CpGV strains.

CO Geostorage and Enhanced Oil Recovery: Challenges in Controlling Foam/Emulsion Generation and Propagation.

CO injection in subterranean reservoirs for storage, oil recovery, or both is challenging because of its very high mobility. Using a CO foam or emulsion is a way to remedy this problem by increasing CO's apparent viscosity. However, the generation of the foam and its propagation in porous media present several issues that have to be overcome for this process to be economically realistic in practice.

New granulovirus strain with high entomopathogenic activity.

We report a genome of CpGV from the bioresource collection of the Federal Research Center of Biological Plant Protection "State Collection of Entomoacariphages and Microorganisms." Its sequence is 123,862 bp. The genome under study demonstrates a degree of similarity of more than 99% with reference NC_002816 from the NCBI RefSeq database.

Assembly and Genome Annotation of Different Strains of Apple Fruit Moth Virus ( granulovirus).

granulovirus is a natural pathogen for that is used as a biocontrol agent of insect populations. The study of granulovirus virulence is of particular interest since the development of resistance in natural populations of has been observed during the long-term use of the Mexican isolate CpGV. In our study, we present the genomes of 18 CpGV strains endemic to southern Russia and from Kazakhstan, as well as a strain included in the commercial preparation "Madex Twin", which were sequenced and analyzed.

[Management of patients with insomnia and polymorbidity. A draft of the clinical guidelines].

Insomnia is a serious and widespread public health problem, but is often undetected and patients do not receive needed treatment. Insomnia is often comorbid with other diseases and conditions, such as arterial hypertension, type 2 diabetes mellitus, pain syndromes, anxiety and depressive disorders, etc. A separate problem is drug-induced insomnia, when patients develop symptoms due to other diseases treatments.

Analysis of the Effects of the and Alleles on Adaptive and Agronomic Traits in Common Wheat ( L.).

Wheat heading time is primarily governed by two loci: VRN-1 (response to vernalization) and PPD-1 (response to photoperiod). Five sets of near-isogenic lines (NILs) were studied with the aim of investigating the effect of the aforementioned genes on wheat vegetative period duration and 14 yield-related traits. Every NIL was sown in the hydroponic greenhouse of the Institute of Cytology and Genetics, SB RAS.

Downregulation of lncRNAs Gomafu, NONMMUT033604.2, and NONMMUT064397.2 in the hippocampus of mice with model of post-traumatic stress disorder.

Objectives: Molecular mechanisms of post-traumatic stress disorder (PTSD) development have been analysed by evaluati-ng changes in the expression level of long non-coding RNA (lncRNA) as a potential biomarker of the disease and as one of the molecular aspects associated with the disease development.

Methods: In our study, we used quantitative polymerase chain reaction (qPCR) to evaluate changes in the expression level of long non-coding RNA - Gomafu, NONMMUT033604.2, and NONMMUT064397.

Foam Generation Through a Single Pore with Rectangular Cross-Section: Hysteretic Behavior and Geometric Limitation of the Volume Fraction of Bubbles.

We study foam production and destabilization through a flow-focusing geometry, namely a single pore of rectangular cross-section, by coinjecting gas and liquid at constant pressure, , and constant flow rate, . We observe that bubble production results from a Rayleigh-Plateau destabilization of the internal gas thread that occurs at the pore neck when its width becomes comparable to the height of the rectangular-section channel. Using a simple model and numerical approach, we (i) predict the shape of the gas jet and its stability range as a function of flow parameters and device geometry, which we successfully compare with our experimental results, and (ii) demonstrate the existence of a critical local pressure drop at the pore neck that determines whether or not a stable gas flow can form.

Straightforward Assessment of Wettability Changes by Washburn Capillary Rise: Toward a Screening Tool for Selecting Water Compositions for Improved Oil Recovery.

Evaluating the wettability state of reservoir rocks is key for understanding and optimizing waterflooding and improved oil recovery techniques that imply the use of low-salinity water. Aside from established petrophysical techniques, such as Amott imbibition tests, we evaluated the Washburn capillary rise method as a low-cost, easy-to-implement, and rapid screening tool for probing the wettability state of rock samples. The well-known limitations of this method are discussed and circumvented.

Physiological Support of Goal-Directed Activity in Human.

The effectiveness of goal-directed human behavior and the processes underlying organization of such activity are the subjects of various biomedical studies. Here we review both classical and modern evidence on the fundamental principles of goal-directed human activity. Facts are presented about the basic mechanisms that ensure the effectiveness of goal-directed behavior and determine its physiological cost.

Bioinformatic Analysis Reveals the Role of Translation Elongation Efficiency Optimisation in the Evolution of Genus.

Translation efficiency modulates gene expression in prokaryotes. The comparative analysis of translation elongation efficiency characteristics of genus bacteria genomes revealed that these characteristics diverge in accordance with the phylogeny of . The first branch of this genus is a group of bacteria commonly found in moist environments such as soil and water that includes the species , , and , which are also described as nosocomial infection pathogens.

Targeted depletion of TRBV9 T cells as immunotherapy in a patient with ankylosing spondylitis.

Autoimmunity is intrinsically driven by memory T and B cell clones inappropriately targeted at self-antigens. Selective depletion or suppression of self-reactive T cells remains a holy grail of autoimmune therapy, but disease-associated T cell receptors (TCRs) and cognate antigenic epitopes remained elusive. A TRBV9-containing CD8 TCR motif was recently associated with the pathogenesis of ankylosing spondylitis, psoriatic arthritis and acute anterior uveitis, and cognate HLA-B*27-presented epitopes were identified.

Plasma oxylipin profiles reflect Parkinson's disease stage.

Derivatives of polyunsaturated fatty acids (PUFAs), also known as oxylipins, are key participants in regulating inflammation. Neuroinflammation is involved in many neurodegenerative diseases, including Parkinson's disease. The development of ultra-high-performance liquid chromatography-mass spectrometry (UPLC-MS/MS) facilitated the study of oxylipins on a system level, i.

Final Results of GERDA on the Two-Neutrino Double-β Decay Half-Life of ^{76}Ge.

We present the measurement of the two-neutrino double-β decay rate of ^{76}Ge performed with the GERDA Phase II experiment. With a subset of the entire GERDA exposure, 11.8 kg yr, the half-life of the process has been determined: T_{1/2}^{2ν}=(2.

Search for tri-nucleon decays of Ge in GERDA.

We search for tri-nucleon decays of Ge in the dataset from the GERmanium Detector Array (GERDA) experiment. Decays that populate excited levels of the daughter nucleus above the threshold for particle emission lead to disintegration and are not considered. The ppp-, ppn-, and pnn-decays lead to Cu, Zn, and Ga nuclei, respectively.

Prototype Expert System for Gout Diagnosis on an Outpatient Basis.

Gout is a systemic disease that is caused by the deposition of monosodium urate crystals in various tissues which leads to inflammation in them. This disease is often misdiagnosed. It leads to the lack of adequate medical care and development of serious complications, such as urate nephropathy and disability.

[Management of patients with insomnia and polymorbidity: expert consensus].

Sleep disorders are becoming increasingly important due to the high comorbidity with other diseases and a significant impact on the patient's quality of life. Insomnia is the most common sleep disorder both in the general population and in patients with multimorbid pathology. Its prevalence in the general population is 6-15%, while in patients with somatic diseases it increases up to 20-40% and can reach 90% in patients with comorbid mental disorders.

Stochastic models of free-molecular nanopore flows.

In gas transport systems of the nanoscale, fluid-surface interactions become the main forces governing the evolution of the flow state. In ideal nanoscale systems, such as atomically smooth carbon nanotubes, the characteristic lengths reduce to such an extent that the non-equilibrium entrance region comprises a large proportion of the domain. In this regime, the added effective resistance induced by the non-equilibrium entrance region becomes large enough that classical effusion models break down.

Liquid argon light collection and veto modeling in GERDA Phase II.

The ability to detect liquid argon scintillation light from within a densely packed high-purity germanium detector array allowed the Gerda experiment to reach an exceptionally low background rate in the search for neutrinoless double beta decay of Ge. Proper modeling of the light propagation throughout the experimental setup, from any origin in the liquid argon volume to its eventual detection by the novel light read-out system, provides insight into the rejection capability and is a necessary ingredient to obtain robust background predictions. In this paper, we present a model of the Gerda liquid argon veto, as obtained by Monte Carlo simulations and constrained by calibration data, and highlight its application for background decomposition.

[Molecular Mechanisms to Optimize Gene Translation Elongation Differ Significantly in Bacteria with and without Nonribosomal Peptides].

Nonribosomal peptides play an important role in the vital activity of bacteria and have an extremely broad field of biological activity. In particular, they act as antibiotics, toxins, surfactants, siderophores, and also perform a number of other specific functions. Biosynthesis of these molecules does not occur on ribosomes but by special enzymes that form gene clusters in bacterial genomes.

Trait-Based Method of Quantitative Assessment of Ecological Functional Groups in the Human Intestinal Microbiome.

We propose the trait-based method for quantifying the activity of functional groups in the human gut microbiome based on metatranscriptomic data. It allows one to assess structural changes in the microbial community comprised of the following functional groups: butyrate-producers, acetogens, sulfate-reducers, and mucin-decomposing bacteria. It is another way to perform a functional analysis of metatranscriptomic data by focusing on the ecological level of the community under study.