Publications by authors named "Kleopatra Eleftheriou"
Article Synopsis
- Drug-loaded thermosensitive liposomes are studied for their potential in delivering anticancer drugs in combination with mild hyperthermia, as they effectively release drugs at specific temperatures (40-42 °C).
- These liposomes incorporate monoalkylether phosphatidylcholine lipids, particularly the methylated PAF derivative, which enhances drug release and has inherent anticancer activity.
- In vitro tests show that these liposomes enable controlled DOX release, improve cancer cell uptake, and effectively inhibit cell viability, especially in human prostate cancer cells.
Liposomes containing lysophospholipids are intensively studied as drug delivery systems that are stable at normal body temperature but exhibit fast release of their drug load at slightly elevated temperatures. In this study, the stability and release properties of dipalmitoylglycerophosphocholine (DPPC)-based liposomes incorporating the commonly used lysophosphatidylocholine (lyso-PC), and a series of monoalkyl chain ether-linked phosphatidylcholine, i.e.
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