The Relationship Between Symptom Change and Use of a Web-Based Self-Help Intervention for Parents of Children With Externalizing Behavior Disorders: Exploratory Study.

Background: Web-based self-help (WASH) has been found to be effective in the treatment of child externalizing behavior disorders. However, research on the associations of caregivers' use of WASH and symptom changes of child externalizing behaviors is lacking.

Objective: This study examined the longitudinal and reciprocal associations between the use of WASH by caregivers of children with externalizing behavior disorders and their children's externalizing behavior symptoms.

Pathogenic relevance of antibodies against desmoglein 3 in patients with oral lichen planus.

Background And Objectives: Oral lichen planus (OLP) is a T cell driven disorder that significantly impairs patients' quality of life. Previous reports suggest that both cellular and humoral activities against desmoglein (dsg) 1 and 3 may be involved in OLP pathogenesis. Here, we aim to analyze the frequency of occurrence and pathological significance of anti-dsg antibodies in a large cohort of OLP patients.

Acceptance and utilization of web-based self-help for caregivers of children with externalizing disorders.

Background: Web-based self-help interventions for parents of children with ADHD and other externalizing disorders have been proven to be effective. In order to recommend individualized and optimized interventions, a better understanding of the acceptance and utilization of this innovative treatment approach is needed. Previous research has frequently employed subjective reports of utilization, but the validity of these studies may be limited.

Inferring glaucoma status from prescriptions, diagnoses, and operations data: A Danish nationwide study.

Purpose: To assess a new method for inferring glaucoma status using prescriptions data.

Methods: The study population comprised all individuals living in Denmark in the period 1995 to 2018 and included 6,930,571 individuals. We used information from The National Prescription Registry on claimed prescriptions as the basis for our study (N = 223,592).

Negative Parenting Mediates the Longitudinal Association between Parental Internalizing Symptoms and Child Oppositional Symptoms.

Research has pointed to both cross-sectional and longitudinal associations between parental internalizing symptoms and child externalizing symptoms. This study analyzed whether the association is mediated by negative parenting behavior in view of previous reports that both parental internalizing symptoms and child externalizing symptoms are related to parenting behaviors. Longitudinal data for the current analyses were derived from a randomized controlled trial on the efficacy of a web-assisted self-help intervention for parents of children with elevated levels of externalizing symptoms.

Parenting Behaviors as Mediators of the Association Between Parental Internalizing Symptoms and Child Externalizing Symptoms.

This study analyzes whether the association between parental internalizing symptoms (depression, anxiety, stress) and child symptoms of attention-deficit/hyperactivity disorder (ADHD) or oppositional defiant disorder (ODD) is mediated by positive and negative parenting behaviors. Cross-sectional data of 420 parents of children (age 6-12 years) with elevated levels of externalizing symptoms were collected in a randomized controlled trial. Measures included parent ratings of their internalizing symptoms and parenting behaviors and of their child's externalizing symptoms.

Biases in reporting of adverse effects in clinical trials, and potential impact on safety assessments in systematic reviews and therapy guidelines.

Background: Clinical trials are an important source of adverse effects data, including analyses in systematic reviews and recommendations in therapy guidelines. Trial publication bias may have profound effects on safety perceptions. This MiniReview presents and discusses biases in reporting of safety data in clinical trials and the implications for systematic reviews and guidelines.

Parkinson's disease, treatment choice and survival over time.

Objectives: We compared Monoamine oxidase B (MAO-B) - and dopamine agonist (DA) monotherapy patients with respect to survival, considering gender, age, first prescriber's specialty and relevant co-morbidity, and compared their specialist health care contacts and hospitalizations.

Methods: With data from health registries, we considered 21,047 patients without redemptions for MAO-B, DA or levodopa 6 months prior to their first MAO-B or DA redemption in 2006 and followed them throughout 2016. We considered Cox proportional hazard regression models for comparing the risk of death among MAO-B and DA monotherapy patients.

English goalkeepers are not responsible for England's poor performance in penalty shootouts in the past.

Scrutinizing public opinion is one of the central goals of science as the divergence between public opinion and scientific evidence can have negative consequences. The present study aims to further investigate the alleged English 'penalty curse' and determine if it can be linked to the prevalent stereotype of the 'English goalkeeper problem'. We analyzed a large sample of 2379 penalty kicks that 629 different goalkeepers faced in World Cups and European Championships, as well as in the Champions and Europa League by comparing the goalkeeper success rates of different nations by fitting a generalized linear model (binomial regression) to the data.

In-play forecasting in football using event and positional data.

Two highly relevant aspects of football, namely forecasting of results and performance analysis by means of performance indicators, are combined in the present study by analysing the value of in-play information in terms of event and positional data in forecasting the further course of football matches. Event and positional data from 50 matches, including more than 300 million datapoints were used to extract a total of 18 performance indicators. Moreover, goals from more than 30,000 additional matches have been analysed.

Time until Need for Levodopa among New Users of Dopamine Agonists or MAO-B Inhibitors.

Objective: To investigate the use of dopamine agonists and monoamine oxidase type B (MAO-B) inhibitors in the Norwegian population, between 1 July 2006 and 31 December 2016. Our primary endpoint was time until need for levodopa among new monotherapy users of dopamine agonists and MAO-B inhibitors.

Methods: A prospective cohort study including all patients, aged 50 years or above, who had at least one prescription for a dopamine agonist or a MAO-B inhibitor dispensed in the study period.

A New Approach for Training-load Quantification in Elite-level Soccer: Contextual Factors.

The aims of this study were to analyse the physical responses of professional soccer players during training considering the contextual factors of match location, season period, and quality of the opposition; and to establish prediction models of physical responses during training sessions. Training data was obtained from 30 professional soccer players from Spanish La Liga using global positioning technology (N=1365 performances). A decreased workload was showed during training weeks prior to home matches, showing large effects in power events, equivalent distance, total distance, walk distance and low-speed running distance.

Male Fertility Before and After Androgen Abuse.

Purpose: Previous research has found that male users of androgens are diagnosed approximately twice as often with infertility. We therefore set out to investigate the fertility in men using androgens.

Methods: The study included 545 males who tested positive for androgens in an anti-doping test program in Danish fitness centers during the period from January 3, 2006, to March 1, 2018.

Comparative effectiveness of dopamine agonists and monoamine oxidase type-B inhibitors for Parkinson's disease: a multiple treatment comparison meta-analysis.

Purpose: To investigate the comparative effectiveness of dopamine agonists and monoamine oxidase type-B (MAO-B) inhibitors available for treatment of Parkinson's disease.

Methods: We performed a systematic literature search identifying randomized controlled trials investigating 4 dopamine agonists (cabergoline, pramipexole, ropinirole, rotigotine) and 3 MAO-B inhibitors (selegiline, rasagiline, safinamide) for Parkinson's disease. We extracted and pooled data from included clinical trials in a joint model allowing both direct and indirect comparison of the seven drugs.

Adverse effects information in clinical guidelines on pharmacological treatment of depression in children and adolescents: a systematic review.

Objectives: To analyse to what extent clinical practice guidelines on drug treatment of depression in children and adolescents mention the risk of adverse effects, to characterise the citations in the guidelines and to assess to what extent data from a major study (Treatment for Adolescents With Depression Study, TADS) was used as basis for information about adverse effects.

Design: Systematic review of clinical guidelines and clinical decision support tools.

Data Sources: PubMed, EMBASE, guideline collections, Health libraries.

Diversity and Conflict.

This research advances the hypothesis and establishes empirically that interpersonal population diversity, rather than fractionalization or polarization across ethnic groups, has been pivotal to the emergence, prevalence, recurrence, and severity of intrasocietal conflicts. Exploiting an exogenous source of variations in population diversity across nations and ethnic groups, as determined predominantly during the exodus of humans from Africa tens of thousands of years ago, the study demonstrates that population diversity, and its impact on the degree of diversity within ethnic groups, has contributed significantly to the risk and intensity of historical and contemporary civil conflicts. The findings arguably reflect the contribution of population diversity to the non-cohesivnesss of society, as reflected partly in the prevalence of mistrust, the divergence in preferences for public goods and redistributive policies, and the degree of fractionalization and polarization across ethnic, linguistic, and religious groups.

Efficacy of web-assisted self-help for parents of children with ADHD (WASH) - a three-arm randomized trial under field/routine care conditions in Germany.

Background: Current clinical guidelines recommend parent management training (PMT) in the treatment of attention-deficit/hyperactivity disorder (ADHD) and oppositional defiant disorder (ODD). However, (a) a lack of supply and (b) structural barriers to attending and continuing face-to-face PMT restrict the access to this training. The main purpose of this study is to investigate the efficacy of online PMT in decreasing ADHD symptoms and oppositional behavior problems and to evaluate the effects of additional telephone-based support of the parents.

Brain Responses to Passive Sensory Stimulation Correlate With Intelligence.

This study investigates the association between intelligence and brain power responses to a passive audiovisual stimulation. We measure the power of gamma-range steady-state responses (SSRs) as well as intelligence and other aspects of neurocognitive function in 40 healthy males born in 1953. The participants are a part of a Danish birth cohort study and the data therefore include additional information measured earlier in life.

Further Evidence of Within-Marriage Fertility Control in Pre-Transitional England.

The identification of parity effects on the hazard of a next birth in cross-family data requires accounting for heterogeneity in fecundity across couples. In a previously published article, Cinnirella et al. Demography, 54, 413-436 (2017), we stratified duration models at the maternal level for this purpose and found that the hazard of a next birth decreases with rising parity in historical England.

Author Correction: Human genealogy reveals a selective advantage to moderate fecundity.

In the version of this article initially published, several sentences contained errors. The sentence "Moreover, the analysis further suggests that evolutionary forces decreased the level of fecundity in the population over this period, consistent with an additional finding that the level of fecundity that maximized long-run reproductive success was above the population mean" contained an error. The word "above" should have been "below".

Human genealogy reveals a selective advantage to moderate fecundity.

Life-history theory suggests that the level of fecundity of each organism reflects the effect of the trade-off between the quantity and quality of offspring on its long-run reproductive success. The present research provides evidence that moderate fecundity was conducive to long-run reproductive success in humans. Using a reconstructed genealogy for nearly half a million individuals in Quebec during the 1608-1800 period, the study establishes that, while high fecundity was associated with a larger number of children, perhaps paradoxically, moderate fecundity maximized the number of descendants after several generations.

Critical appraisal of adverse effects reporting in the 'Treatment for Adolescents With Depression Study (TADS)'.

Objective: To identify all publications from the 'Treatment for Adolescents With Depression Study (TADS)' and assess the findings regarding occurrence of any adverse effects in the treatment groups both for the short-term and long-term study stages.

Design: Descriptive analysis of TADS publications with any information on adverse effects.

Results: We identified 48 publications describing various aspects of the TADS, in which 439 adolescent patients received treatment with fluoxetine, cognitive-behavioural therapy, cognitive-behavioural therapy plus fluoxetine or placebo.

A multiple treatment comparison meta-analysis of monoamine oxidase type B inhibitors for Parkinson's disease.

Aims: To the best of our knowledge, there are no systematic reviews or meta-analyses that compare rasagiline, selegiline and safinamide. Therefore, we aimed to perform a drug class review comparing all available monoamine oxidase type B (MAO-B) inhibitors in a multiple treatment comparison.

Methods: We performed a systematic literature search to identify randomized controlled trials assessing the efficacy of MAO-B inhibitors in patients with Parkinson's disease.

A Multiple Treatment Comparison of Eleven Disease-Modifying Drugs Used for Multiple Sclerosis.

Background: Several disease-modifying drug therapies are available for the treatment of multiple sclerosis (MS). To ensure the most appropriate MS management, we assessed the effectiveness and cost-effectiveness of the disease-modifying medicines used for MS.

Methods: We conducted a systematic review including 11 disease-modifying drugs used for treatment of adult patients diagnosed with relapsing-remitting MS.