INPP4B promotes PDAC aggressiveness via PIKfyve and TRPML-1-mediated lysosomal exocytosis.

Aggressive solid malignancies, including pancreatic ductal adenocarcinoma (PDAC), can exploit lysosomal exocytosis to modify the tumor microenvironment, enhance motility, and promote invasiveness. However, the molecular pathways through which lysosomal functions are co-opted in malignant cells remain poorly understood. In this study, we demonstrate that inositol polyphosphate 4-phosphatase, Type II (INPP4B) overexpression in PDAC is associated with PDAC progression.

Impact of Baseline Anxiety on Well-being in People with Post-COVID-19 Condition: A Secondary Analysis.

Background: Post-COVID-19 condition (PCC) is associated with a host of psychopathological conditions including prominent anxiety symptoms. However, it is not known what effect anxious symptoms have on measures of well-being in individuals living with PCC. This study aims to evaluate anxiety's association with measures of well-being in people with PCC.

Gesture is the primary modality for language creation.

How language began is one of the oldest questions in science, but theories remain speculative due to a lack of direct evidence. Here, we report two experiments that generate empirical evidence to inform gesture-first and vocal-first theories of language origin; in each, we tested modern humans' ability to communicate a range of meanings (995 distinct words) using either gesture or non-linguistic vocalization. Experiment 1 is a cross-cultural study, with signal Producers sampled from Australia ( = 30, = 32.

Increasing population size can inhibit cumulative cultural evolution.

The extent to which larger populations enhance cumulative cultural evolution (CCE) is contentious. We report a large-scale experiment ( = 543) that investigates the CCE of technology (paper planes and their flight distances) using a transmission-chain design. Population size was manipulated such that participants could learn from the paper planes constructed by one, two, or four models from the prior generation.

Preserved GLP-1 effects in a diabetic patient with Cushing's disease.

Context: A patient with diabetes mellitus, who participated in a study with intravenous administration of GLP-1, was later found to have Cushing's disease (markedly elevated 24 h urinary cortisol excretion and inadequate suppression of fasting cortisol with 2 mg dexamethasone). His diabetic state disappeared (2 h plasma glucose after 75 g oral glucose 159 mg/dl=IGT) after successful pituitary surgery (normal 24 h urinary cortisol excretion and adequate cortisol suppression with 2 mg dexamethasone).

Objective: The present analysis was undertaken to compare GLP-1 actions on fasting glycemia in diabetes mellitus due to Cushing's disease with GLP-1 actions in typical type 2 diabetes.

Glucagonostatic actions and reduction of fasting hyperglycemia by exogenous glucagon-like peptide I(7-36) amide in type I diabetic patients.

Objective: Glucagon-like peptide I(7-36) amide (GLP-1) is a physiological incretin hormone that, in slightly supraphysiological doses, stimulates insulin secretion, lowers glucagon concentrations, and thereby normalizes elevated fasting plasma glucose concentrations in type II diabetic patients. It is not known whether GLP-1 has effects also in fasting type I diabetic patients.

Research Design And Methods: In 11 type I diabetic patients (HbA1c 9.

Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients.

Glucagon-like peptide 1 (GLP-1) (7-36 amide) is a physiological incretin hormone that is released after nutrient intake from the lower gut and stimulates insulin secretion at elevated plasma glucose concentrations. Previous work has shown that even in Type 2 (non-insulin-dependent) diabetic patients GLP-1 (7-36 amide) retains much of its insulinotropic action. However, it is not known whether the magnitude of this response is sufficient to normalize plasma glucose in Type 2 diabetic patients with poor metabolic control.

About the possibilities of registration of drug influence by means of radiocardiographic function analysis.

Changes in cardiac dynamics were analyzed by means of radiocardiographic function analysis under an infusion of epinephrine using the method of RAB. Typical changes in heart rate, stroke volume and blood pressure were observed after the application of epinephrine. Compared to examinations under physical exercise in case of healthy control subjects there was no typical decrease of enddiastolic volume dependent on the heart rate.

Estimation of cardiac function by means of radiocardiographic function analysis.

The radiocardiographic function analysis represents a relatively simple procedure for the clinician to collect information concerning the changes of cardiac dynamics. The advantage of this method is to register non-invasively changes in cardiac dynamics at rest and during exercise such as those of enddiastolic volume, stroke volume, endsystolic volume, ejection time and filling time, and to permit the calculation of mean ejection velocity, etc. After insertion of a cardiac catheter, it is possible to record the corresponding pressure pulse in the right ventricle or in the pulmonary vessels simultaneously.

[The influence of the plasmaexpander hydroxyethyl starch on the serological blood grouping tests as compared to dextran 60 and whole blood (author's transl)].

The influence of HES on serological blood grouping (ABO. Rh. crossmatch) was tested in comparison with dextran.