[Esophageal carcinoma: the final results of a multicenter and controlled German study with misonidazole and radiation].

A prospective, randomized clinical study on 91 patients with squamous cell carcinoma of the oesophagus was undertaken in order to investigate the radiosensitizing effect of misonidazole. After histologic verification and extensive diagnosis, the greater tumor region was at first irradiated during 2.5 weeks with ten fractions of 3 Gy each up to a target volume dose of 30 Gy.

[Salmon calcitonin in metastatic bone pain. Demonstration of acute analgesia in tumor patients].

Infusion of 200 IU Calcitonin-Sandoz in 20 of 44 hospitalized patients with malignant tumor suffering from chronic severe pain due to bone metastases, reduced the intensity of pain and with it the need for analgesics for an average of 10 hours. The result points to an analgesic potential of salmon-calcitonin.

[Postoperative radiotherapy of astrocytomas grade 3 and 4 with the radiosensitizer misonidazole. -End results of a multicentric controlled German study].

102 patients entered a multicentric randomized study from May 1978 till December 1980. After an operative removal of a supratentorial astrocytoma grade 3 or 4 all patients were treated by radiotherapy of the whole brain with 40 Gy, and after a rest of 1 to 2 weeks with a boost dose of 20 Gy to the tumor region. By randomization the patients got misonidazole (400 mg/m2) to each of the 30 fractions or a placebo.

[Combination of chemotherapy and local radiation therapy for metastases to the lung or liver: indication and results (author's transl)].

42 patients with metastases to the lung and 7 patients with metastases to the liver received a combined treatment with polychemotherapy and local gamma-irradiation simultaneously. Radiation doses to the lung were mostly 15 Gy in 12 days up to 18 Gy in 2 1/2 weeks (657 to 731 ret). Right and left lung were never treated at the same time.