Publications by authors named "Kleber R Fidelis"

Mercury chloride (HgCl) acts as a bioaccumulator capable of causing numerous neurological and physiological changes in organisms in a negative way. However, rutin has been considered a very effective antioxidant compound in the treatment of neurodegenerative diseases, as it can neutralize radicals capable of damaging neuronal cells. In this context, this study aimed to evaluate rutin as a neoprotective agent against the damage induced by HgCl in Drosophila melanogaster.

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Plants are natural sources of several bioactive substances, which have been found in extracts, secondary metabolites, and essential oils. Several biological activities have been attributed to essential oils as antiviral, insecticidal, antiparasitic, antioxidant, and antimicrobial. The indiscriminate use of antibiotics has increased the development of resistance mechanisms of microorganisms.

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Paraquat (PQ) is a widely used herbicide with no antidote which is implicated in the pathogenesis of the Parkinson's disease. The present study then investigated the potential of caffeic acid (CA), a known antioxidant, cardioprotective and neuroprotective molecule to counteract oxidative stress mediated by PQ. In addition, molecular docking was performed to understand the mechanism underlying the inhibitory effect of CA against PQ poisoning.

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Objectives: Postgraduate programmes around the world are periodically subjected to research performance evaluation through bibliometric indicators. In this research, we characterized and compared the research performance of 15 universities from Northeastern Brazil, in which 13 were among the top Universities of the Latin America.

Methods: Specifically, total documents, citations and the h-index of each university were retrieved from the Elsevier Scopus database and were analysed not only for historical scientific achievement but also across the period of the past 6 years (2010-2015).

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