Ru(II) based dual nitric oxide donors: electrochemical and photochemical reactivities and vasorelaxant effect with no cytotoxicity.

The synthesized complexes, -[Ru(NO)(NO)(phen)](PF) (NONO2P) and -[Ru(NO)(NO)(bpy)](PF) (NONO2B), were characterized by using elemental analysis, voltammetry and electronic and vibrational spectroscopy. Under electrochemical and photochemical stimulation in an aqueous medium, there are indications of the formation of complexes, which suggests that the nitro and nitrosyl groups are converted into nitric oxide. Both compounds do not show cytotoxic activity against human umbilical vein endothelial cells (HUVECs).

The macrocyclic effect and vasodilation response based on the photoinduced nitric oxide release from trans-[RuCl(tetraazamacrocycle)NO](2+).

Irradiation of trans-[RuCl(cyclam)(NO)](2+), cyclam is 1,4,8,11-tetraazacyclotetradecane, at pHs 1-7.4, with near UV light results in the release of NO and formation of trans-[Ru(III)Cl(OH)(cyclam)](+) with pH dependent quantum yields (from approximately 0.01 to 0.

Design of an NO photoinduced releaser xerogel based on the controlled nitric oxide donor trans-[Ru(NO)Cl(cyclam)](PF6)2 (cyclam=1,4,8,11-tetraazacyclotetradecane).

The immobilization and properties of the nitric oxide donor trans-[Ru(NO)Cl(cyclam)](PF(6))(2), RuNO, entrapped in a silica matrix by the sol-gel process is reported herein. The entrapped nitrosyl complex was characterized by spectroscopic (UV-vis, infrared (IR), X-ray photoelectron, and (13)C and (29)Si MAS NMR) and electrochemical techniques. The entrapped species exhibit one characteristic absorption band in the UV-vis region of the electronic spectrum at 354 nm and one IR nu(NO) stretching band at 1865 cm(-1), as does the RuNO species in aqueous solution.

Solvent dependent conformational isomerism and ligand oxidation of novel Ru(II) cyclen complexes.

The synthesis of cis-[Ru(II)(cyclen)(L)(x)](n+) (cyclen = 1,4,7,10-tetraazacyclododecane and L = 2,2'-bipyridine (bpy), phenanthroline (phen) or 4-cyanopyridinium (4-NCpyH(+))) is reported. The freshly prepared complexes are stable in aprotic solvents and cyclen undergoes oxidative dehydrogenation reaction at high pH. These compounds also present solvent dependent conformational isomerization.