Publications by authors named "Kleanthis Dendrinos"
Background: Approximately 5-10 % of ulcerative colitis (UC) patients who undergo ileal pouch-anal anastomosis (IPAA) will develop postoperative complications such as refractory pouchitis or a change in diagnosis to Crohn's disease (CD). Serological markers and histologic aspects of the pouch such as pyloric gland metaplasia (PGM) have been associated with a risk for these complications.
Methods: Twenty-eight IPAA patients with either CD of the pouch or chronic pouchitis (cases) and 36 IPAA controls who experienced a normal postoperative course were originally consented.
Article Synopsis
- The study investigates the clinical and pathological characteristics of patients with Crohn's disease limited to the colon and compares them with those who have both ileal and colonic involvement.
- Patients with isolated colonic Crohn's disease were diagnosed at an older age and had a shorter duration of symptoms before surgery compared to those with ileocolonic Crohn's disease.
- Pathologically, isolated colonic Crohn's patients exhibited fewer severe features and a notable portion presented with a form resembling ulcerative colitis, but the presence of these features did not predict adverse outcomes post-surgery.
Although serologic testing for perinuclear antineutrophil cytoplasmic antibodies (pANCA) and anti-Saccharomyces cerevisiae antibodies (ASCA) is reportedly useful in distinguishing ulcerative colitis (UC) from Crohn's disease (CD), there are few and conflicting reports assessing their utility in predicting postoperative complications after ileal pouch-anal anastomosis (IPAA). We examined the associations between postoperative complications such as pouchitis or fistulas and pANCA and ASCA antibodies in a group of patients who underwent IPAA for UC. We conducted a retrospective chart review of 34 patients initially diagnosed with UC (four of these patients had a diagnosis of indeterminate colitis) who underwent IPAA by a single surgeon, and who had pANCA and ASCA antibody levels measured during their clinical course.
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