[Cell therapy of critical lower limb ischemia (problems and prospects)].

Critical limb ischemia is a syndrome that combines several peripheral artery diseases with different ethiology and pathogenesis but with similar prognosis, high morbidity and mortality. Possibility of surgical and conservative treatment of critical limb ischemia almost completely exhausted. Some hopes have arisen due to progress in cell technology.

[Novel method of analysis of risk of development of ischemic heart disease with the use of genomic and computer technologies].

Aim: to assess effectiveness of the use of modern methods of prognostication for assessment of risk of development of ischemic heart disease (IHD).

Material And Methods: We examined 131 patients with diagnosis of IHD verified by coronary angiography and 159 subjects of control group. Initial information on each patient included the following parameters: traditional risk factors, laboratory parameters, results of instrumental examination, genetic markers.

[The role of genetic predisposition in the development of cardiovascular diseases (myocardial infarction, ischemic stroke, unstable stenocardia) and its interaction with conventional risk factors].

To assess the risk of cardiovascular events, the diagnostic effectiveness of molecular-genetic markers (polymorphisms in APOE, ACE (I/D) and MTHFR (C677T) genes) in combination with conventional risk factors has been studied. The prognostic effectiveness of common algorithms (the Framingham scale) is not sufficient for evaluation of risk factors for cardiovascular diseases. The combination of results of molecular-genetic testing with conventional risk factors allows to increase the predictability of cardiovascular risks.

[Evaluation of the severity of aortic stenosis using 2-dimensional Doppler echocardiography].

Hemodynamic evaluation of aortic ostial stenosis (AOS) was made in 89 patients at Doppler echocardiography. Maximal circulation rate (MCR) through the aortic valve averaged 3.47 +/- 0.

[Intermittent effect of asbestos dust and pleural carcinogenesis in rats].

Frequent intrapleural injections of the asbestos dust induce in rats more mesotheliomae tht the rare ones in the same and large doses.

[Ankylosing hyperostosis of the spine (Forestier's disease). A study of its clinical picture based on the data from a mail questionnaire].

Postal questionnaires were used to study the incidence and intensity of complaints of the spine and peripheral skeleton in patients with ankylosing hyperostosis of the spine. Selection of persons to fill in questionnaires was carried out by means of a preliminary non-randomized analysis of the records of the spinal fluorograms in patients of one of the outpatient clinics of Moscow. Criteria for ankylosing hyperostosis of the spine were the presence of continuous ossification of the anterior longitudinal ligament over a length of not less than 4 successive segments of the spine and the lack of other x-ray alterations in the given part of the spine.

[The sodium selenite inhibition of asbestos-induced carcinogenesis in Wistar rats].

Sodium selenite given in drinking water in a 4 ppm solution during the whole experiment was found to significantly inhibit pleural carcinogenesis induced in Wistar rats by intrapleural injection of chrysotile-asbestos powder (20 mg three times, monthly, in 0.5 ml of physiologic saline). Mesothelioma of the pleura was induced in 20.

[The assessment of left ventricular diastolic function in patients with aortic defects].

Thirty patients with aortic heart disease and 10 healthy persons were examined for diastolic function of the left ventricle using two-dimensional Doppler echocardiography. The decline of the rate and volume of early diastolic filling, the rise of the filling during the atrial systole were revealed in 60% of the patients with aortal disease. The decrease of the ejection fraction of the left ventricle was noted in 23.