Non-interventional observational study broadens positive benefit-risk assessment of an immunomodulating herbal remedy in the common cold.

The unique extract of a mixture of radix, radix and herba alleviates the typical symptoms of the common cold and shortens the duration of the disease. The risk-benefit ratio of a concentrated formulation of this herbal extract was investigated under everyday conditions. Pharmacy-based, non-interventional, multicenter, open, uncontrolled study registered at DRKS00011068.

Clinical trial shows lasting function of a new moisturizing cream against vaginal dryness.

Vaginal dryness and associated symptoms may occur in women of any age and are a frequent burden after menopause. The North American Menopause Society recommends long-acting non-hormonal vaginal creams as first-line therapy. A new type of such creams was developed (Remifemin® FeuchtCreme in Austria and Germany).

Risk assessment of free hydroquinone derived from Arctostaphylos Uva-ursi folium herbal preparations.

Uva-ursi folium (bearberry leaf) has been traditionally used to treat symptoms of lower urinary tract infections. The most representative constituent of this herbal drug is arbutin that is rapidly absorbed in the small intestine and undergoes hepatic conjugation to form hydroquinone (HQ) conjugates. As free HQ is crucial for the safety of the herbal preparation, we reviewed published and unpublished experimental and human studies to clarify some outdated assumptions and to support the safety of therapeutic daily doses of Uva-ursi folium extract.

Suspected black cohosh hepatotoxicity: no evidence by meta-analysis of randomized controlled clinical trials for isopropanolic black cohosh extract.

Objective: Black cohosh, a popular herbal treatment for menopausal symptoms, has been implicated in a number of hepatotoxicity case reports. The purpose of this investigation was to analyze data gained from clinical trials on the effect of black cohosh on liver function.

Methods: A meta-analysis of randomized, double-blind, and controlled clinical trials was conducted.