Publications by authors named "Klaus Wessel"
Advanced glycation endproducts (AGEs) accumulate on long-lived proteins, including beta-amyloid plaques in Alzheimer's disease, and are suggested to contribute to neuronal dysfunction and cell death. We have investigated the effects of a model AGE upon glucose metabolism and energy production in a neuroblastoma cell line. AGEs decrease cellular ATP levels and increase glucose consumption and lactate production.
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- The study investigates the safety and effectiveness of alpha-lipoic acid (ALA) for treating diabetic sensory symptoms in patients with diabetic sensorimotor polyneuropathy, focusing on its impact on the Total Symptom Score (TSS).
- Diabetic patients were randomly assigned to receive either ALA (600 mg) or a placebo in a double-blind setup, and after 14 treatments, the ALA group showed a significant reduction in TSS compared to the placebo group (5.7 vs. 1.8 points).
- The findings suggest that intravenous ALA improves positive neuropathic symptoms like pain without increasing nerve fiber degeneration, supporting its safety and potential as a treatment option.