GC-NPD analysis of topiramate in capillary dried plasma: assessing chemical dependency pharmacotherapy.

This study aimed to develop and validate a GC-NPD method for quantifying topiramate (TPM) in capillary dried plasma spots (DPS). Extraction involved three 6 mm DPS with albumin 0.1%, alkaline liquid extraction with tert-Butyl methyl ether and TMAH methylation.