A method for computing the fraction of attributable risk related to climate damages.

The recent decision of the U.S. Supreme Court on the regulation of CO2 emissions from new motor vehicles shows the need for a robust methodology to evaluate the fraction of attributable risk from such emissions.

Gene therapy for HIV infection: what does it need to make it work?

The efficacy of antiviral drug therapy for HIV infection is limited by toxicity and viral resistance. Thus, alternative therapies need to be explored. Several gene therapeutic strategies for HIV infection have been developed, but in clinical testing therapeutically effective levels of the transgene product were not achieved.

Impact of gene-modified T cells on HIV infection dynamics.

Previous clinical trials in HIV-infected patients involving infusion of T cells protected by an antiviral gene have failed to show any therapeutic benefit. The value of such a treatment approach is thus still highly controversial. In this study, the anticipated effects of gene-modified cells on virus and T-cell kinetics are analysed by mathematical modeling.