Publications by authors named "Klaus Eberhard Stewien"
Genetic variability in G2 and F2 region between biological clones of human respiratory syncytial virus with or without host immune selection pressure.
Claudia Trigo Pedroso Moraes Danielle Bruna Leal Oliveira Angelica Cristine Almeida Campos Patricia Alves Bosso Hildener Nogueira Lima Klaus Eberhard Stewien
Mem Inst Oswaldo Cruz
February 2015
Article Synopsis
- Human respiratory syncytial virus (HRSV) is a significant respiratory illness affecting young children, making vaccine development challenging due to host immunity and the virus's genetic variability.
- This study identified differences in HRSV biological clones from clinical samples, noting specific mutations in the F and G genes in relation to serum from convalescent children and their mothers.
- Findings suggest that host antibodies may influence the selection of viral sequences, complicating the creation of effective vaccines by contributing to the virus's evolutionary process.
Molecular epidemiology of the SH (small hydrophobic) gene of human respiratory syncytial virus (HRSV), over 2 consecutive years.
Hildenêr Nogueira Lima Viviane Fongaro Botosso Danielle Bruna Leal Oliveira Angélica Cristine de Almeida Campos Andrea Lima Leal Klaus Eberhard Stewien
Virus Res
January 2012
Human respiratory syncytial virus (HRSV) strains were isolated from nasopharyngeal aspirates collected from 965 children between 2004 and 2005, yielding 424 positive samples. We sequenced the small hydrophobic protein (SH) gene of 117 strains and compared them with other viruses identified worldwide. Phylogenetic analysis showed a low genetic variability among the isolates but allowed us to classify the viruses into different genotypes for both groups, HRSVA and HRSVB.
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