Defining and Measuring Crewmember Operational State for Spaceflight Operations.

Introduction: A suite of human health and performance metrics can be used to provide a holistic cognitive, physical, and emotional view of an individual and assess how well they are integrated with the overall system during spaceflight missions. The combination of such individual metrics as defined here is notionally termed "crewmember operational state."

Methods: This work identifies and defines the contributing components that comprise the proposed crewmember operational state.

Exome Sequencing Detects Uniparental Disomy of Chromosome 4 Revealing a LARP7 Pathogenic Variant Responsible for Alazami Syndrome: A Case Report.

Alazami syndrome is an autosomal recessive disease characterized by global developmental delay, growth restriction, and distinctive facial features. Fewer than 50 individuals are currently reported with biallelic loss of function variants in LARP7. We report the case of a 3.

A retrospective analysis of the need for on-site emergency physician presence and mission characteristics of a rural ground-based emergency medical service.

Background: This study aimed to address the challenges faced by rural emergency medical services in Europe, due to an increasing number of missions and limited human resources. The primary objective was to determine the necessity of having an on-site emergency physician (EP), while the secondary objectives included analyzing the characteristics of rural EP missions.

Methods: A retrospective study was conducted, examining rural EP missions carried out between January 1st, 2017, and December 2nd, 2021 in Burgenland, Austria.

Live stream of prehospital point-of-care ultrasound during cardiopulmonary resuscitation - A feasibility trial.

Background: Current resuscitation guidelines recommend that skilled persons could use ultrasound to detect reversible causes during cardiopulmonary resuscitation (CPR) where the examination can be safely integrated into the Advanced Life Support (ALS) algorithm. However, in a prehospital setting performing and rapidly interpreting ultrasound can be challenging for physicians. Implementing remote, expert-guided, and real-time transmissions of ultrasound examinations offers the opportunity for tele-support, even during an out-of-hospital cardiac arrest (OHCA).

Resting state functional connectivity changes following mindfulness-based stress reduction predict improvements in disease control for patients with asthma.

Background: The staggering morbidity associated with chronic inflammatory diseases can be reduced by psychological interventions, including Mindfulness-Based Stress Reduction (MBSR). Proposed mechanisms for MBSR's beneficial effects include changes in salience network function. Salience network perturbations are also associated with chronic inflammation, including airway inflammation in asthma, a chronic inflammatory disease affecting approximately 10% of the population.

Categorization of Select Cockpit Performance Evaluation Techniques.

The modern aircraft cockpit has evolved into a complex system of systems. Numerous performance evaluation metrics and techniques exist that can measure the effectiveness of cockpit components in terms of how they influence the human operator's ability to perform tasks relevant to mission success. As no prior review of these metrics has been found in the literature, this effort attempts to do so, albeit without applying the metrics to a novel cockpit evaluation.

Eye-tracking during simulation-based echocardiography: a feasibility study.

Introduction: Due to the technical progress point-of-care ultrasound (POCUS) is increasingly used in critical care medicine. However, optimal training strategies and support for novices have not been thoroughly researched so far. Eye-tracking, which offers insights into the gaze behavior of experts may be a useful tool for better understanding.

Clinically relevant effects of Mindfulness-Based Stress Reduction in individuals with asthma.

Background: Psychological distress and comorbid psychopathology contribute to exacerbation risk in patients with asthma. Thus, interventions designed to reduce stress and improve emotion regulation, such as Mindfulness-Based Stress Reduction (MBSR), may augment standard care. Few studies have addressed this question and a paucity of data exists to determine the ability of MBSR to impact clinical outcomes in asthma.

Simulated Micro-, Lunar, and Martian Gravities on Earth-Effects on Growth, Phenotype, and Sensitivity to Antibiotics.

Bacterial behavior has been studied under microgravity conditions, but very little is known about it under lunar and Martian gravitational regimes. An Earth-based approach was designed and implemented using inclined clinostats and an in-house-developed code to determine the optimal clinorotation angular speed for bacterial liquid cultures of 5 RPM. With this setup, growth dynamics, phenotypic changes, and sensitivity to antibiotics (minimum inhibitory concentration (MIC) of two different classes of antibiotics) for three strains (including uropathogenic) were examined under simulated micro-, lunar, and Martian gravities.

Tongue ties do not widen the upper airways in racehorses.

Background: There is contradictory evidence on the potential benefits of tongue ties on upper airway function and their efficacy in inhibiting intermittent dorsal displacement of the soft palate (DDSP) in racehorses.

Objectives: To test the hypothesis that tongue ties increase the pharyngeal diameter and decrease the occurrence of dynamic airway obstruction in racehorses.

Study Design: Prospective, crossover blinded clinical study.

Hamiltonian Engineering with Multicolor Drives for Fast Entangling Gates and Quantum Crosstalk Cancellation.

Quantum computers built with superconducting artificial atoms already stretch the limits of their classical counterparts. While the lowest energy states of these artificial atoms serve as the qubit basis, the higher levels are responsible for both a host of attractive gate schemes as well as generating undesired interactions. In particular, when coupling these atoms to generate entanglement, the higher levels cause shifts in the computational levels that lead to unwanted ZZ quantum crosstalk.

Generation of an alpaca serum that induces immune-mediated crescentic glomerulonephritis in mice.

Crescentic glomerulonephritis (cGN) is the most aggressive form of glomerulonephritis in humans. A widely studied mouse model is induced by sheep or rabbit antisera raised against murine renal cortical antigens. We here, report that Alpaca readily produce ample amounts of antisera that induces pathology in mice, resembling human disease regarding crescent formation, proteinuria, infiltrating immune cells and a significant Th1, but not Th17 immune response.

Demonstration of a High-Fidelity cnot Gate for Fixed-Frequency Transmons with Engineered ZZ Suppression.

Improving two-qubit gate performance and suppressing cross talk are major, but often competing, challenges to achieving scalable quantum computation. In particular, increasing the coupling to realize faster gates has been intrinsically linked to enhanced cross talk due to unwanted two-qubit terms in the Hamiltonian. Here, we demonstrate a novel coupling architecture for transmon qubits that circumvents the standard relationship between desired and undesired interaction rates.

Tunable Coupling Architecture for Fixed-Frequency Transmon Superconducting Qubits.

Implementation of high-fidelity 2-qubit operations is a key ingredient for scalable quantum error correction. In superconducting qubit architectures, tunable buses have been explored as a means to higher-fidelity gates. However, these buses introduce new pathways for leakage.

Side-by-Side Comparison of Human Perception and Performance Using Augmented, Hybrid, and Virtual Reality.

Alternative reality (XR) technologies, including physical, augmented, hybrid, and virtual reality, offer ways for engineered spaces to be evaluated. Traditionally, practitioners (such as those designing spacecraft habitats) have relied on physical mockups to perform such design evaluations, but digital XR technologies present several streamlining advantages over their physical counterparts. These digital environments vary in their level of virtuality, and consequently have different effects on human perception and performance, with respect to a completely physical mockup environment.

Nucleophilic C-H Etherification of Heteroarenes Enabled by Base-Catalyzed Halogen Transfer.

We report a general protocol for the direct C-H etherification of -heteroarenes. Potassium -butoxide catalyzes halogen transfer from 2-halothiophenes to -heteroarenes to form -heteroaryl halide intermediates that undergo tandem base-promoted alcohol substitution. Thus, the simple inclusion of inexpensive 2-halothiophenes enables regioselective oxidative coupling of alcohols with 1,3-azoles, pyridines, diazines, and polyazines under basic reaction conditions.

Stability and Change in Intergenerational Family Relations Across Two Decades: Findings From the German Ageing Survey, 1996-2014.

Objectives: Using high-quality data from Germany, this study aims to contribute to the yet little knowledge about possible changes in adult parent-child relationships within countries over time.

Method: Analyzing 13,106 interviews from four rounds of the German Ageing Survey (DEAS), covering the period 1996-2014, we monitor stability and change in four dimensions of adult parent-child relationships, namely geographic proximity, frequency of contact, emotional closeness, and exchange of support.

Results: We observed a continuous decrease in parent-child geographic proximity between 1996 and 2008, but no further increase in distance thereafter.

Design of a spaceflight biofilm experiment.

Biofilm growth has been observed in Soviet/Russian (Salyuts and Mir), American (Skylab), and International (ISS) Space Stations, sometimes jeopardizing key equipment like spacesuits, water recycling units, radiators, and navigation windows. Biofilm formation also increases the risk of human illnesses and therefore needs to be well understood to enable safe, long-duration, human space missions. Here, the design of a NASA-supported biofilm in space project is reported.

Impact of a remifentanil supply shortage on mechanical ventilation in a tertiary care hospital: a retrospective comparison.

Background: The continuous administration of opioids in critical care patients is a common therapy for the tolerance of mechanical ventilation. Opioid choice has a crucial impact on the length of mechanical ventilation. Owing to its very short context-sensitive half-life, remifentanil widens the available options for sedoanalgetic strategies.

Intraosseous Sliding Plate Fixation Used in Double Osteotomy Bunionectomy.

Background:: Distal chevron metatarsal osteotomy bunionectomy is a commonly performed procedure for the treatment of mild to moderate hallux valgus. We continue to use the intraosseous sliding osteotomy plate system for fixation of the distal metatarsal osteotomy. With the addition of the Akin osteotomy, we are able to obtain reliable, reproducible correction with better cosmesis and increased patient satisfaction for more advanced deformities.

Assessment of Conduit-Assisted Primary Nerve Repair Strength With Varying Suture Size, Number, and Location.

Outcomes following digital nerve repair are suboptimal despite much research and various methods of repair. Increased tensile strength of the repair and decreased suture material at the repair site may be 2 methods of improving biologic and biomechanical outcomes, and conduit-assisted repair can aid in achieving both of these goals. Ninety-nine fresh-frozen digital nerves were equally divided into 11 different groups.

Spaceflight Modifies Gene Expression in Response to Antibiotic Exposure and Reveals Role of Oxidative Stress Response.

Bacteria grown in space experiments under microgravity conditions have been found to undergo unique physiological responses, ranging from modified cell morphology and growth dynamics to a putative increased tolerance to antibiotics. A common theory for this behavior is the loss of gravity-driven convection processes in the orbital environment, resulting in both reduction of extracellular nutrient availability and the accumulation of bacterial byproducts near the cell. To further characterize the responses, this study investigated the transcriptomic response of to both microgravity and antibiotic concentration.

Spacecraft cabin environment effects on the growth and behavior of Chlorella vulgaris for life support applications.

An Environmental Control and Life Support System (ECLSS) is necessary for humans to survive in the hostile environment of space. As future missions move beyond Earth orbit for extended durations, reclaiming human metabolic waste streams for recycled use becomes increasingly important. Historically, these functions have been accomplished using a variety of physical and chemical processes with limited recycling capabilities.