Publications by authors named "Klaus Brendel"
Article Synopsis
- Hereditary angioedema (HAE) is a rare genetic condition affecting about 1 in 50,000 people, leading to unpredictable swelling attacks that significantly impact patients' quality of life.
- A survey conducted with 99 patients revealed that anxiety about attack occurrences and physical limitations during attacks are major concerns, though many patients receive regular treatment and are generally satisfied with their therapies.
- Despite high satisfaction levels, 62% of patients showed strong interest in an oral long-term prophylactic (LTP), as it simplifies treatment and may further improve their quality of life.
This study extends the use of two lathyrogens, ss-aminopropionitrile (BAPN) and D-penicillamine (DPA) from daily systemic or local-topical administration to long-time acting agents. This was achieved by converting the hydrophilic drugs into lipophilic derivatives. The synthesis of functional derivatives of DPA consisted in esterification with methyl-, hexyl-, or benzyl alcohols in the presence of thionylchloride.
View Article and Find Full Text PDFBoth cynomolgus and rhesus monkeys are utilized in chemical toxicity screening and drug development studies by industry and government laboratories. Along with better utilization of their tissue for in vivo studies, it would be advantageous if the tissue could be cold-preserved or cryopreserved for future in vitro experimentation. Therefore, livers were excised from control monkeys and precision-cut tissue slices were prepared.
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