Publications by authors named "Klaus Bonaventura"
Article Synopsis
- - The study examined the prognostic value of inducible ventricular arrhythmia (VA) in patients with syncope who received defibrillators, comparing them to patients with prior heart issues needing secondary prevention.
- - Results showed that patients with syncope and inducible VA had fewer heart-related issues and better clinical outcomes after one year, including lower mortality and adverse events than those with a secondary preventive indication.
- - Importantly, while patients with syncope and inducible VA had favorable outcomes, their post-surgery complication rates were similar to those without syncope, highlighting the significance of VA inducibility in risk assessment.
Background: As the number of cardiac diseases continuously increases within the last years in modern society, so does cardiac treatment, especially cardiac catheterization. The procedure of a cardiac catheterization is challenging for both patients and practitioners. Several potential stressors of psychological or physical nature can occur during the procedure.
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- * Eight international experts were connected to the examination site, showing good internet transmission quality, although challenges like internet stability were noted.
- * Physicians demonstrated strong agreement in their evaluation of the exams, and participants expressed a positive reception towards using AR technology for remote supervision in education and movement analysis.
Background: The metabolic syndrome (MetS) is a risk cluster for a number of secondary diseases. The implementation of prevention programs requires early detection of individuals at risk. However, access to health care providers is limited in structurally weak regions.
View Article and Find Full Text PDFSocial media applications on smartphones allow for new avenues of instruction in sports medicine and exercise sciences. This study tested the feasibility of instructing health care personnel through videos of ultrasound vascular measurements distributed by a social media messenger application. After two training sessions with an ultrasound device, voluntary physicians (n=10) and nurses (n=10) received a video for the performance of an ultrasound-guided determination of intima-media-thickness and diameter of the femoral arteries via a social media messenger application.
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- Coronary bifurcation lesions pose significant challenges in PCI, often leading to sub-optimal outcomes; DCB technology is emerging as a potential solution.
- The review examines current bifurcation PCI techniques, highlights advancements in DCB technology, and discusses clinical experiences and studies related to its use in treating these complex lesions.
- While initial studies show promise for DCB in bifurcation treatment, further larger trials and consensus are necessary for broader acceptance and application in clinical settings.
Article Synopsis
- - The study investigates the effectiveness of scoring balloon angioplasty (SBA) used before drug-coated balloon (DCB) angioplasty in a diverse group of patients with new and recurrent coronary lesions, aiming to improve clinical outcomes.
- - A total of 481 patients with different types of lesions were analyzed, with a primary goal of measuring target lesion failure (TLF) rates after 9 months; findings showed a low overall TLF rate of 3.0% but higher rates for in-stent restenotic lesions.
- - Results indicated that while SBA is beneficial for treating new lesions (1.1% TLF rate), it was less effective for patients with previously placed bare metal or drug-eluting stents, suggesting
Background: In recent decades, guideline-based therapy of myocardial infarction has led to a considerable reduction in myocardial infarction mortality. However, there are relevant differences in acute care and the extent of infarction mortality. The objective of this survey was to analyze the current care situation of patients with acute myocardial infarction in the region of northeast Germany (Berlin, Brandenburg and Mecklenburg-Vorpommern).
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- Transcatheter aortic valve replacement (TAVR) is a treatment for high-risk patients with severe aortic valve stenosis, with atrial fibrillation (AF) being common among them, increasing the risk of bleeding complications due to anticoagulation therapy.
- A study of 283 TAVR patients showed that those with AF experienced nearly three times more major vascular complications and life-threatening bleeding compared to those with normal sinus rhythm.
- Patients with AF also had significantly higher overall mortality rates within the first month and year after the procedure, indicating the need for further research into optimal anticoagulation strategies.
Background: Reduced left ventricular ejection fraction (LVEF) ≤30% is the most powerful prognostic indicator for sudden cardiac death (SCD) in patients after myocardial infarction (MI), but there are little data about long-term changes of LVEF after revascularization and the following implantation of a cardioverter defibrillator (ICD).
Methods: We performed a retrospective analysis of 277 patients with reduced LVEF at least 1 month after MI and complete revascularization. Patients (median time post-MI 23.
Background: Scoring balloons produce excellent acute results in the treatment of in-stent restenosis (ISR), fibro-calcific and bifurcation lesions but have not been shown to affect the restenosis rate. A novel paclitaxel-coated scoring balloon (SB) was developed and tested to overcome this limitation.
Methods And Results: SB were coated with paclitaxel admixed with a specific excipient.
Background: Nonadherence to drug therapy poses a significant problem in the treatment of patients with presumed resistant hypertension. It has been shown that therapeutic drug monitoring (TDM) is a useful tool for detecting nonadherence and identifying barriers to treatment adherence, leading to effective blood pressure (BP) control. However, the cost-effectiveness of TDM in the management of resistant hypertension has not been investigated.
View Article and Find Full Text PDFAims: Coronary artery aneurysms (CAA) are a rare complication after percutaneous coronary intervention (PCI) and are reported with an incidence of 0.6% to 3.9%.
View Article and Find Full Text PDFAims: Drug-coated balloon catheters (DCB) are a new clinical treatment modality for coronary and peripheral artery disease. The goal of the consensus group is to develop recommendations for the clinical use of DCB based on randomized clinical trials and the best available clinical evidence. The present paper gives an update on the recommendations against the background of a variety of new data published since the first paper was presented.
View Article and Find Full Text PDFBackground: The economic impact of drug-eluting stent (DES) in-stent restenosis (ISR) is substantial, highlighting the need for cost-effective treatment strategies.
Hypothesis: Compared to plain old balloon angioplasty (POBA) or repeat DES implantation, drug-coated balloon (DCB) angioplasty is a cost-effective therapy for DES-ISR.
Methods: A Markov state-transition model was used to compare DCB angioplasty with POBA and repeat DES implantation.
Background: Recent studies have demonstrated a superior diagnostic accuracy of cardiovascular magnetic resonance (CMR) for the detection of coronary artery disease (CAD). We aimed to determine the comparative cost-effectiveness of CMR versus single-photon emission computed tomography (SPECT).
Methods: Based on Bayes' theorem, a mathematical model was developed to compare the cost-effectiveness and utility of CMR with SPECT in patients with suspected CAD.
Aims: Recent studies have demonstrated the safety and efficacy of catheter-based renal sympathetic denervation (RDN) for the treatment of resistant hypertension. We aimed to determine the cost-effectiveness of this approach separately for men and women of different ages.
Methods And Results: A Markov state-transition model accounting for costs, life-years, quality-adjusted life-years (QALYs), and incremental cost-effectiveness was developed to compare RDN with best medical therapy (BMT) in patients with resistant hypertension.
Background: Preparticipation examinations (PPE) are frequently used to evaluate eligibility for competitive sports in adolescent athletes. Nevertheless, the effectiveness of these examinations is under debate since costs are high and its validity is discussed controversial.
Purpose: To analyse medical findings and consequences in adolescent athletes prior to admission to a sports school.
Background: Recent studies have demonstrated the safety and efficacy of drug-coated balloon (DCB) angioplasty for the treatment of coronary in-stent restenosis (ISR). The cost-effectiveness of this practice is unknown.
Methods: A Markov state-transition decision analytic model accounting for varying procedural efficacy rates, complication rates, and cost estimates was developed to compare DCB angioplasty with drug-eluting stent (DES) placement in patients with bare-metal stent (BMS)-ISR.
Aims: Percutaneous coronary interventions for bifurcation lesions are often complex and associated with an unsatisfactory result. The aim of this first-in-man, observational study was to investigate the efficacy and safety of a paclitaxel-eluting balloon in these lesions.
Methods And Results: Twenty-eight patients presenting significant coronary bifurcational lesions of the left coronary artery were studied.
The high rate of restenosis associated with percutaneous coronary intervention (PCI) procedures can be reduced with the implantation of metallic stents into the stenotic vessels. The knowledge that neointimal formation can result in restenosis after stent implantation led to the development of drug-eluting stents (DES) which require long lasting antiplatelet therapy to avoid thrombotic complications. In the last years, the drug-eluting balloon (DEB) technology has emerged as an alternative option for the treatment of coronary and peripheral arteries.
View Article and Find Full Text PDFAims: The study aims to determine the direct costs and comparative cost-effectiveness of latest-generation dual-source computed tomography (DSCT) and invasive coronary angiography for diagnosing coronary artery disease (CAD) in patients suspected of having this disease.
Methods: The study was based on a previously elaborated cohort with an intermediate pretest likelihood for CAD and on complementary clinical data. Cost calculations were based on a detailed analysis of direct costs, and generally accepted accounting principles were applied.
Several cytokines are activated in chronic heart failure (CHF), including interleukin-2 (IL-2). IL-2 is important for the survival of regulatory T cells, as well as for the function of activated T cells. Its role in ischemic cardiomyopathy has not yet been investigated.
View Article and Find Full Text PDFBradykinin (BK) coronary outflow and left ventricular (LV) performance of kininogen-deficient Brown Norway Katholiek (BNK) rats and Brown Norway Hannover (BNH) controls were investigated. We analyzed whether the angiotensin-converting enzyme (ACE) inhibitor ramipril is able to attenuate LV dysfunction after induction of myocardial infarction (MI) in this animal model. Ex vivo, the basal BK content in the coronary outflow of buffer-perfused, isolated hearts was measured by specific radioimmunoassay.
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