Publications by authors named "Klaske Oberman"
Whole body vibration, an alternative for exercise to improve recovery from surgery?
Brain Behav Immun Health
December 2022
Article Synopsis
- A study compared whole body vibration (WBV) to regular exercise in rats recovering from major abdominal surgery to explore alternative rehabilitation methods.
- Rats were separated into groups receiving either WBV or treadmill exercise for 15 days, with control rats undergoing pseudo treatment.
- Both WBV and exercise were found to help maintain cognitive flexibility and neurogenesis post-surgery, but only exercise increased anxiety-like behavior, suggesting that WBV may be a beneficial low-impact option for recovery.
Background: Inflammation is considered a key factor in the development of postoperative cognitive dysfunction (POCD). Therefore, we hypothesized that pre-operative anti-inflammatory treatment with ibuprofen would inhibit POCD in our rat-model.
Methods: Male Wistar rats of 3 or 23 months old received a single injection of ibuprofen (15 mg/kg i.
Background: Soluble oligomeric amyloid-β (Aβ), rather than Aβ plaques, seems to be the culprit in Alzheimer's disease (AD). Accordingly, a new concept vaccine of small cyclic peptide conjugates, selectively targeting oligomeric Aβ, has been developed.
Objective: Study the therapeutic potential of this new vaccine in a mouse model for AD.