Publications by authors named "Klasiena Bouwman"

Background: Hidradenitis suppurativa (HS) is a multifactorial inflammatory skin disease that is considered to be an immune-mediated inflammatory disease (IMID). Up till now, the impact of lifestyle on (the development of) HS has not been thoroughly investigated.

Objectives: To investigate the effect of dietary intake and physical activity (PA) on (the development of) HS.

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Hidradenitis suppurativa (HS) is a heterogeneous chronic relapsing skin disease. Several assessment tools are used to assess disease severity and to classify disease phenotype; however, no consensus exists. This review evaluates the various assessment tools and phenotypes, assessing their validity and reliability.

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Article Synopsis
  • The study evaluated the effectiveness of guselkumab, an anti-IL-23p19 monoclonal antibody, for treating moderate-to-severe hidradenitis suppurativa (HS) over 16 weeks.
  • A phase IIa trial showed that 65% of patients achieved significant clinical improvement, with decreases in Hidradenitis Suppurativa Clinical Response (HiSCR) scores and inflammatory nodules.
  • Even though inflammatory markers in the skin were reduced in responders, overall patient-reported outcomes did not reflect significant improvement, and only one serious adverse event occurred, deemed likely unrelated to the treatment.
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Introduction: Cohort studies on the use of retinoids for hidradenitis suppurativa (HS) have yielded contradicting results. As the clinical presentation of HS is heterogeneous, with different predilection sites and hallmark features, it can be hypothesized that HS phenotypes are associated with the effectiveness of specific retinoid treatments.

Objectives: The aim of this study was to evaluate the drug survival of oral retinoids in the treatment of HS and to establish predictors for longer treatment duration.

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Background: Hidradenitis suppurativa (HS) is a chronic autoinflammatory skin condition and is associated with several comorbidities. Previous studies report variable prevalence rates of HS, depending on the methodology. However, the exact prevalence remains unknown.

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