Mutated Huntingtin Causes Testicular Pathology in Transgenic Minipig Boars.

Background: Huntington's disease is induced by CAG expansion in a single gene coding the huntingtin protein. The mutated huntingtin (mtHtt) primarily causes degeneration of neurons in the brain, but it also affects peripheral tissues, including testes.

Objective: We studied sperm and testes of transgenic boars expressing the N-terminal region of human mtHtt.